{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:11Z","timestamp":1791842891290,"version":"4.3.4"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infraorbital hyperpigmentation is a common condition, and due to its multifactorial nature, it is less responsive to standard treatments. Therefore, the aim of our research was to evaluate the efficiency of microneedling and tranexamic acid with microneedling and vitamin C in the treatment of dark circles around the eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The present research was a prospective, single-blind, randomized clinical trial. Thirty-seven female candidates who had been referred to the skin clinic of Imam Hospital of Ahvaz for treating dark circles around their eyes were included. People were divided into two groups on both sides under the eyes (right and left). For randomization, in treatment method A, microneedling and tranexamic acid were used for the right side of patient\u2019s face, microneedling and vitamin C treatment for the left side, and the opposite was considered for group B. All analyses were performed using SPSS version 22 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both methods presented dramatic advancement in all sessions compared to the baseline. There was no remarkable difference between the two groups regarding treatment methods (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.444). The patients\u2019 consent showed no considerable difference between the two sides. Unfavorable incidents were non-permanent, with no dramatic diversity between both sides except for burning that lasted longer with microneedling and vitamin C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both tranexamic acid and vitamin C, in combination with microneedling, appear to be impressive modalities for the management of infraorbital hyperpigmentation with no remarkable side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_287_23","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T14:01:07Z","timestamp":1767103267000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparing the Efficiency of Microneedling and Tranexamic Acid Versus Microneedling and Vitamin C in the Treatment of Infraorbital Hyperpigmentation"],"prefix":"10.4103","volume":"14","author":[{"given":"Nader","family":"Pazyar","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Badakhsh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Yaghoobi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Seyedtabib","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"R1-20251230","first-page":"49","article-title":"Periorbital hyperpigmentation: A comprehensive review","volume":"9","author":"Sarkar","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"R2-20251230","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1080\/09546634.2020.1819527","article-title":"Efficacy and safety of fractional CO2 laser and tranexamic acid versus microneedling and tranexamic acid in the treatment of infraorbital hyperpigmentation","volume":"33","author":"Ghandehari","year":"2022","journal-title":"J Dermatol Treat"},{"key":"R3-20251230","first-page":"13","article-title":"Hyperpigmentation therapy: A review","volume":"7","author":"Desai","year":"2014","journal-title":"JCAD"},{"key":"R4-20251230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3126\/njdvl.v16i1.19411","article-title":"Periorbital hyperpigmentation: Overcoming the challenges in the management","volume":"16","author":"Agrawal","year":"2018","journal-title":"Nepal J Dermatol Venereol Leprol"},{"key":"R5-20251230","doi-asserted-by":"crossref","first-page":"522","DOI":"10.5021\/ad.2018.30.5.522","article-title":"Treatments of infra-orbital dark circles by various etiologies","volume":"30","author":"Park","year":"2018","journal-title":"Ann Dermatol"},{"key":"R6-20251230","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1080\/09546634.2020.1855297","article-title":"Decoding infraorbital dark circles with lasers and fillers. 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