{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:56Z","timestamp":1787775896813,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postmenopausal bleeding might occur due to many benign and malignant underlying diseases. Differentiating between these diseases poses a great importance. This study was designed to compare the diagnostic value of pipelle endometrial sampling and curettage in patients with postmenopausal bleeding. Further, the results were compared with hysterectomy if performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Eighty-seven patients with postmenopausal bleeding were included. Pipelle sampling endometrial biopsy was performed for patients in office, and then, patients were transferred to the operation room for dilatation and curettage. Pathology results of pipelle sampling were compared with curettage method. If hysterectomy was performed due to any reason, it was compared as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The pipelle sampling biopsy diagnosed 94.1% of malignant tumors, and curettage sampling biopsy diagnosed 100% of malignant tumors. The sensitivity and specificity of pipelle compared to curettage were 94.12% and 100%, respectively, for the diagnosis of malignant tumors. Based on the Kappa test, the agreement between pipelle and curettage sampling biopsy was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The endometrial sampling with pipelle is safe and cost-effective in patients referred with postmenopausal bleeding. This might avoid the need for general anesthesia for the detection of endometrial hyperplasia and endometrial malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_28_20","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T05:35:21Z","timestamp":1604295321000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic Values of Pipelle and Standard Curettage Compared to Hysterectomy Pathology in Postmenopausal Bleeding: A Comparative Study"],"prefix":"10.4103","volume":"9","author":[{"given":"Fariba","family":"Behnamfar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"R1-20250805","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.7314\/APJCP.2015.16.12.4971","article-title":"Comparison the Diagnostic Value of Dilatation and Curettage Versus Endometrial Biopsy by Pipelle--a Clinical Trial","volume":"16","author":"Moradan","year":"2015","journal-title":"Asian Pacific journal of cancer prevention: APJCP"},{"key":"R2-20250805","doi-asserted-by":"crossref","first-page":"582","DOI":"10.26719\/2011.17.7.582","article-title":"Histological findings in women with postmenopausal bleeding: Jordanian figures","volume":"17","author":"Bani-Irshaid","year":"2011","journal-title":"East Mediterr Health J"},{"key":"R3-20250805","first-page":"1","article-title":"Clinical management of vaginal bleeding in postmenopausal women","volume":"1","author":"Carugno","year":"2020","journal-title":"Climacteric"},{"key":"R4-20250805","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/GME.0000000000000186","article-title":"Differential effects of menopausal therapies on the endometrium","volume":"21","author":"Mirkin","year":"2014","journal-title":"Menopause"},{"key":"R5-20250805","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jmig.2019.06.004","article-title":"Histopathology and clinical outcomes of 151 women with postmenopausal bleeding treated with resectoscopic surgery","volume":"27","author":"Vilos","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"R6-20250805","first-page":"58","article-title":"Approach to diagnosis and management of abnormal uterine bleeding","volume":"53","author":"Telner","year":"2007","journal-title":"Can Fam Physician"},{"key":"R8-20250805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9378(16)32276-1","article-title":"Diagnostic dilation and curettage: A reappraisal","volume":"142","author":"Grimes","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"R9-20250805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5152\/jtgga.2013.01","article-title":"Pipelle endometrial sampling versus conventional dilatation & curettage in patients with abnormal uterine bleeding","volume":"14","author":"Abdelazim","year":"2013","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"R10-20250805","first-page":"405","article-title":"Endometrial sampling prior to hysterectomy","volume":"73","author":"Stovall","year":"1989","journal-title":"Obstet Gynecol"},{"key":"R11-20250805","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-9378(94)70234-9","article-title":"A randomized comparison of the Pipelle, Accurette, and Explora endometrial sampling devices","volume":"170","author":"Lipscomb","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"R12-20250805","first-page":"828","article-title":"Comparison of Novak and Pipelle endometrial biopsy instruments","volume":"78","author":"Silver","year":"1991","journal-title":"Obstet Gynecol"},{"key":"R13-20250805","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/1097-0142(20001015)89:8<1765::AID-CNCR17>3.0.CO;2-F","article-title":"The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia: A meta-analysis","volume":"89","author":"Dijkhuizen","year":"2000","journal-title":"Cancer"},{"key":"R14-20250805","first-page":"553","article-title":"Pipelle endometrial sampling. Sensitivity in the detection of endometrial cancer","volume":"40","author":"Guido","year":"1995","journal-title":"J Reprod Med"},{"key":"R15-20250805","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1034\/j.1600-0412.2001.080009784.x","article-title":"Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial hyperplasia","volume":"80","author":"Clark","year":"2001","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R16-20250805","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00404-014-3523-y","article-title":"Accuracy of endometrial sampling compared to conventional dilatation and curettage in women with abnormal uterine bleeding","volume":"291","author":"Abdelazim","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"R17-20250805","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5144\/0256-4947.2008.188","article-title":"Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding","volume":"28","author":"Fakhar","year":"2008","journal-title":"Ann Saudi Med"},{"key":"R18-20250805","first-page":"CR271","article-title":"Is pipelle biopsy really adequate for diagnosing endometrial disease?","volume":"10","author":"Tanriverdi","year":"2004","journal-title":"Med Sci Monit"},{"key":"R19-20250805","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0301-2115(96)02658-9","article-title":"Comparison of cytospat and pipelle endometrial biopsy instruments","volume":"72","author":"Antoni","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R20-20250805","first-page":"142","article-title":"Correlation between preoperative endometrial sampling and final endometrial cancer histology","volume":"33","author":"Sany","year":"2012","journal-title":"Eur J Gynaecol Oncol"},{"key":"R21-20250805","first-page":"65","article-title":"Types and frequencies of pathologies in endometrial curettings of abnormal uterine bleeding","volume":"1","author":"Sarwar","year":"2018","journal-title":"Int J Pathol"},{"key":"R22-20250805","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00404-012-2438-8","article-title":"Which is the best technique for endometrial sampling. Aspiration (pipelle) versus dilatation and curettage (D&C)?","volume":"286","author":"Demirkiran","year":"2012","journal-title":"Arch Gynecol Obstet"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_28_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:45:40Z","timestamp":1787773540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_28_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_28_20","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-02-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}