{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:58Z","timestamp":1787764858831,"version":"build-2784847793"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Complications or death risk factors is necessary for better monitoring and treatment. The aim of this study was to define the relative risk of toxico-clinical parameters with regard to poisoning severity and outcomes in patients with acute poisoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study entailed of patients with acute poisoning admitted to the poisoning emergency center of khorshid hospital, Isfahan, Iran from December 2018 until March 2019. Patients (n = 300) were categorized into four groups (minor, moderate, severe, and fatal poisoning) based on severity. Multivariate logistic regression analysis was employed to calculate the odds ratio (OR) as the estimate of the relative risk of the different variables for the poisoning severity and outcomes prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the minor group, opioids\/opiates, alcohols, and benzodiazepines (14.7%) were the most prevalent poisoning, multidrug (23.3%) was in the moderate and severe groups and finally, pesticides poisoning (23%) was most common in the fatal group. The predictive factors for poisoning severity were pre-hospital antidote administration [OR, (95%CI);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value) [7.08 (1.77-28.34); 0.006]; loss of consciousness [4.38 (1.84-10.42), 0.001]; abnormal ECG [4.56 (1.65-12.56); 0.003]; and time interval of poisoning to admission in the hospital [1.15 (1.02-1.28); 0.01). Patients without complications was observed in 49.7% of subjects. Patients with the loss of consciousness [66.06 (2.41-180.07); 0.01); underlying disease [3.65 (1.09-12.24); 0.03]; abnormal respiration [1.14 (1.02-1.27); 0.02); have had a greater risk of complications and death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Important factors for poisoning severity and\/or outcome were loss of consciousness, pre-hospital antidote administration, abnormal ECG or respiration, underlying disease, and delay to presentation to hospital.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_290_21","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:17:24Z","timestamp":1698373044000},"page":"107","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["The Relative Risk of Toxico-Clinical Parameters with respect to Poisoning Severity and Outcomes in Patients with Acute Poisoning"],"prefix":"10.4103","volume":"11","author":[{"given":"Nastaran","family":"Eizadi-Mood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasol","family":"Heshmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokhsareh","family":"Meamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Motamedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-107-20240830","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/toxics8020028","article-title":"Clinical and epidemiological characteristics of severe acute adult poisoning cases in martinique: Implicated toxic exposures and their outcomes","volume":"8","author":"Resiere","year":"2020","journal-title":"Toxics"},{"key":"R2-107-20240830","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1038\/s41598-019-44986-7","article-title":"Epidemiological characteristics of pesticide poisoning in Jiangsu Province, China, from 2007 to 2016","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"R3-107-20240830","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1186\/s12889-020-09939-0","article-title":"The global distribution of acute unintentional pesticide poisoning: Estimations based on a systematic review","volume":"20","author":"Boedeker","year":"2020","journal-title":"BMC Public Health"},{"key":"R4-107-20240830","first-page":"1","article-title":"Drug overdose deaths in the United States, 1999-2018","volume":"56","author":"Hedegaard","year":"202;","journal-title":"NCHS Data Brief"},{"key":"R5-107-20240830","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jflm.2008.12.004","article-title":"Poisoning severity score, APACHE II and GCS: Effective clinical indices for estimating severity and predicting outcome of acute organophosphorus and carbamate poisoning","volume":"16","author":"Sam","year":"2009","journal-title":"J Forensic Leg Med"},{"key":"R6-107-20240830","first-page":"29","article-title":"APACHE II, APACHE III, SOFA scoring systems, platelet counts and mortality in septic and nonseptic patients","volume":"11","author":"Balci","year":"2005","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"R7-107-20240830","first-page":"209","article-title":"Estimation of the mortality rate using the APACHE II standard disease severity scoring system in intensive care unit patients","volume":"4","author":"Asadzandi","year":"2012","journal-title":"Iran J Crit Care Nurs (IJCCN"},{"key":"R8-107-20240830","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/15563659809028940","article-title":"Poisoning severity score. 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