{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:13Z","timestamp":1786653613807,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"\n Background:<\/jats:title>\n \n Allium<\/jats:italic>\n genus with 750 species is the most diverse genus in the Amaryllidaceae family. Historically,\n Allium<\/jats:italic>\n species have been used as medicinal plants, especially for prevention and treatment of cardiovascular diseases and considered as valuable sources of phytonutrients. Phytochemical investigation of\n Allium tripedale<\/jats:italic>\n , locally called \u201cAnashq,\u201d which is an edible plant of the \u201cZagros\u201d region (west of Iran) was conducted in the present study.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Air-dried bulbs of the plant were extracted in a four-step extraction method with increasing polarity using hexane, chloroform, chloroform\u2013methanol (9:1), and methanol. Chloroform-methanol (9:1) extract was fractionated by medium-pressure liquid chromatography on a RP-18 column using a linear gradient solvent system of H\n 2<\/jats:sub>\n O to MeOH. Phenolic-rich fractions were subjected to the final isolation and purification of the constituents by reversed-phase high-performance liquid chromatography method. Structure elucidation of the compounds was performed through comprehensive methods including 1D-and 2D-NMR and mass spectroscopy.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Two cinnamic acid derivatives were isolated from the bulbs of\n A. tripedale<\/jats:italic>\n ; using spectroscopic methods, their chemical structures were determined as 6,7-dimethoxy N-trans-caffeoyltyramine (1) and N-trans-feruloyltyramine (2).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Cinnamic acid derivatives are pharmacologically active phenolic compounds, which have been isolated from different\n Allium<\/jats:italic>\n species. Isolation of these compounds from\n A. tripedale<\/jats:italic>\n is reported for the first time in this study and could be used as a chemical basis for explanation of the plant biological and pharmacological activities.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_34_17","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T06:16:48Z","timestamp":1524464208000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Isolation of Cinnamic Acid Derivatives from the Bulbs of Allium tripedale"],"prefix":"10.4103","volume":"7","author":[{"given":"Zahra","family":"Chehri","sequence":"first","affiliation":[{"name":"From the Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Sadeghi Dinani","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1021\/jf020396t","article-title":"Chemical composition of shallot (Allium ascalonicum hort.)","volume":"50","author":"Fattorusso","year":"2002","journal-title":"J Agric Food Chem"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/np0503350","article-title":"The sapogenin atroviolacegenin and its diglycoside atroviolaceoside from Allium atroviolaceum","volume":"69","author":"Zolfaghari","year":"2006","journal-title":"J Nat Prod"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chroma.2005.12.016","article-title":"The analysis of onion and garlic","volume":"1112","author":"Lanzotti","year":"2006","journal-title":"J Chromatogr A"},{"key":"R4-20251008","first-page":"277","article-title":"Determination of antidiabetic activity in Allium cepa (onion) tissue cultures","volume":"38","author":"Kelkar","year":"2001","journal-title":"Indian J Biochem Biophys"},{"key":"R5-20251008","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000497643","article-title":"Antidiabetic and hypo-lipidemic properties of garlic (Allium sativum) in steretozotocin induced diabetic rats","volume":"15","author":"Thomson","year":"2007","journal-title":"Int J Diabetes Metab"},{"key":"R6-20251008","first-page":"12","article-title":"Allium L. Subgen rhizirideumsensulato in Iran, two new records and a synopsis of taxonomy and phytogeography","volume":"13","author":"Memariani","year":"2007","journal-title":"J Bot"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"372","DOI":"10.5642\/aliso.20062201.31","article-title":"Phylogeny and new intrageneric classification of Allium (Alliaceae) based on nuclear ribosomal DNA ITS Sequences","volume":"22","author":"Friesen","year":"2006","journal-title":"Aliso"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.phytol.2013.04.007","article-title":"Antifungal cinnamic acid derivatives from Persian leek (Allium ampeloprasum subsp. persicum)","volume":"6","author":"Sadeghi","year":"2013","journal-title":"Phytochem Lett"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1021\/jo035758q","article-title":"Electron-transfer reaction of cinnamic acids and their methyl esters with the DPPH radical in alcoholic solutions","volume":"69","author":"Foti","year":"2004","journal-title":"J Org Chem"},{"key":"R10-20251008","first-page":"817","article-title":"Synthesis, antiinflammatory and anticancer activity of cinnamic acids, their derivatives and analogues","volume":"27","author":"Zhang","year":"1992","journal-title":"Yao Xue Xue Bao"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1248\/bpb.26.1057","article-title":"Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines","volume":"26","author":"Akao","year":"2003","journal-title":"Biol Pharm Bull"},{"key":"R12-20251008","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1021\/jf903581f","article-title":"Cysteine sulfoxides and volatile sulfur compounds from allium tripedale","volume":"58","author":"Kusterer","year":"2010","journal-title":"J Agric Food Chem"},{"issue":"2","key":"R13-20251008","first-page":"112","article-title":"The effect of hydroalcoholic extract of Nectaroscordum tripedaleon liver and kidney functional parameters in streptozocin-induced diabetic male rats","volume":"18","author":"Paydar","year":"2016","journal-title":"IJEM"},{"issue":"1","key":"R14-20251008","first-page":"54","article-title":"The in vitro inhibitory effects of the aqueous extracts of summer onion on Candida albicans","volume":"21","author":"Panahi","year":"2013","journal-title":"SJIMU"},{"key":"R15-20251008","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/jf048116s","article-title":"Authentication and quantitative analysis on the chemical profile of Cassia bark (Cortex cinnamomi) by high-pressure liquid chromatography","volume":"53","author":"He","year":"2005","journal-title":"J Agric Food Chem"},{"key":"R16-20251008","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1021\/jf0511291","article-title":"A universal HPLC method for the determination of phenolic acids in compound herbal medicines","volume":"53","author":"Wen","year":"2005","journal-title":"J Agric Food Chem"},{"key":"R17-20251008","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1271\/bbb.61.1138","article-title":"Isolation and activity of N-p-coumaroyltyramine, an \u03b1-glucosidase inhibitor in welsh onion (Allium fistulosum)","volume":"61","author":"Nishioka","year":"1997","journal-title":"Biosci Biotechnol Biochem"},{"key":"R18-20251008","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1021\/jf9018382","article-title":"Isolation and characterization of N-feruloyltyramine as the P-selectin expression suppressor from garlic (Allium sativum)","volume":"57","author":"Park","year":"2009","journal-title":"J Agric Food Chem"},{"key":"R19-20251008","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.phytochem.2006.10.009","article-title":"Saponins from Allium minutiflorum with antifungal activity","volume":"68","author":"Barile","year":"2007","journal-title":"Phytochemistry"},{"key":"R20-20251008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/11263509909381549","article-title":"Antifungal N-feruloyl amides from roots of Allium species","volume":"133","author":"Fattorusso","year":"1999","journal-title":"Plant Biosyst"},{"key":"R21-20251008","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1124\/jpet.105.097337","article-title":"Clovamide-type phenylpropenoic acid amides, N-coumaroyldopamine and N-caffeoyldopamine, inhibit platelet-leukocyte interactions via suppressing P-selectin expression","volume":"317","author":"Park","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"R22-20251008","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1021\/jf0516078","article-title":"Quantitation of clovamide-type phenylpropenoic acid amides in cells and plasma using high-performance liquid chromatography with a colorimetric electrochemical detector","volume":"19","author":"Park","year":"2005","journal-title":"J Agric Food Chem"},{"key":"R23-20251008","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3892\/ijmm.2015.2301","article-title":"N-trans-\u03c1-caffeoyl tyramine isolated from Tribulus terrestris exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 cells","volume":"36","author":"Ko","year":"2015","journal-title":"Int J Mol Med"},{"key":"R24-20251008","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.canlet.2003.08.010","article-title":"N-caffeoyltyramine arrests growth of U937 and Jurkat cells by inhibiting protein tyrosine phosphorylation and inducing caspase-3","volume":"202","author":"Park","year":"2003","journal-title":"Cancer Lett"}],"container-title":["Advanced Biomedical 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