{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:03Z","timestamp":1787775723725,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psoriatic arthritis (PsA) is a systemic auto-immune condition characterized by diverse and distinctive inflammation, affecting both musculoskeletal and extra-articular systems. This study aims to investigate the role of regulatory T-cells (Tregs), specifically the CD4+CD25+\/high CD127-\/low subset, in PsA pathogenesis, and their potential as biomarkers and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In a case-control study involving 40 PsA patients and 25 healthy individuals, CD4+ CD25+\/high CD127-\/low Tregs were analyzed in peripheral blood mononuclear cells (PBMCs) using flow cytometry. Disease activity was assessed using the Disease Activity in Psoriatic Arthritis (DAPSA) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We observed a significant positive correlation between Treg levels and the DAPSA score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) in non-treated PsA patients. Additionally, patient age showed a significant positive correlation with erythrocyte sedimentation rate in the same group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04), emphasizing the potential influence of Tregs on disease activity and age-related effects on inflammatory markers in PsA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While not revealing significant differences in Treg populations, our research underscores the importance of considering specific Treg subsets in PsA. These subsets may respond differently to disease micro-environments and treatments, affecting disease progression. This study contributes to the broader comprehension of immune dysregulation in auto-immune diseases and suggests that further investigation into Treg subsets\u2019 function and count is warranted. Such insights may lead to more tailored therapeutic approaches for PsA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_359_23","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:00:10Z","timestamp":1727150410000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of CD4+ CD25+\/high CD127low\/- Regulatory T-Cells in Different Stages of Psoriatic Arthritis Patients"],"prefix":"10.4103","volume":"13","author":[{"given":"Roya","family":"Safari","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Cellular and Molecular Research Centre, Medical Basic and Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 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