{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:38:37Z","timestamp":1787841517369,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Inflammatory bowel disease (IBD) is a digestive system ailment that causes significant bodily disruption. This problem may coexist with other digestive system illnesses. One of the diseases that reduces the quality of life and other disorders is functional dyspepsia (FD), the diagnosis of which is associated with unique limitations. In this study, we aim to investigate the relative frequency of FD in IBD patients and compare it with a healthy control group.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In a case-control study, we selected a group of IBD patients and healthy controls, and all participants were prepared for a diagnosis of FD symptoms using ROME IV criteria. Data were analyzed and compared using Chi-square and\n t<\/jats:italic>\n -test, and\n P<\/jats:italic>\n \u2264 0.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There were 100 IBD patients, including 91 with ulcerative colitis and 9 with Crohn\u2019s disease (mean age, 41.37 \u00b1 13; 39 males, 61 females). Furthermore, 100 healthy control subjects (mean age, 44.23 \u00b1 14; 38 males, 62 females) were analyzed. 10% of IBD patients met the criteria of FD, which was comparable with the controls (5, 5%) (\n P<\/jats:italic>\n > 0.05). Some of the symptoms of irritable bowel syndrome (IBS) including abdominal pain (\n P<\/jats:italic>\n = 0.01) and bowel movement\n (P<\/jats:italic>\n = 0.02) were significantly higher in IBD patients than in non-IBD subjects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The symptoms of FD were not significantly greater in IBD patients compared to the control group, while IBS symptoms were significantly higher in IBD individuals, indicating a possible overlap of Rome IV IBS and FD.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_369_23","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:02:40Z","timestamp":1722240160000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Relative Frequency of Gastrointestinal Functional Disorders in Patients with Inflammatory Bowel Disease Based on Rome IV: A Case-Control Study"],"prefix":"10.4103","volume":"13","author":[{"given":"Maryam","family":"Soheilipour","sequence":"first","affiliation":[{"name":"Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh Ghasemi","family":"Chermahini","sequence":"additional","affiliation":[{"name":"Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Tamizifar","sequence":"additional","affiliation":[{"name":"Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazila","family":"Kassaian","sequence":"additional","affiliation":[{"name":"Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh Rahim","family":"Khorasani","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Adibi","sequence":"additional","affiliation":[{"name":"Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: Current state of the art","volume":"13","author":"de Souza","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cgh.2010.03.003","article-title":"Functional dyspepsia impacts absenteeism and direct and indirect costs","volume":"8","author":"Brook","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/apt.12355","article-title":"Functional dyspepsia: The economic impact to patients","volume":"38","author":"Lacy","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/nmo.12578","article-title":"No increase in prevalence of somatization in functional vs organic dyspepsia: A cross-sectional survey","volume":"27","author":"Gracie","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cgh.2009.07.020","article-title":"Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia","volume":"8","author":"Ford","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.3748\/wjg.v25.i31.4414","article-title":"Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment","volume":"25","author":"Barros","year":"2019","journal-title":"World J Gastroenterol"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4292\/wjgpt.v7.i1.78","article-title":"Diagnosis and management of functional symptoms in inflammatory bowel disease in remission","volume":"7","author":"Teruel","year":"2016","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"910568","DOI":"10.3389\/fphys.2022.910568","article-title":"The role of gastrointestinal microbiota in functional dyspepsia: A review","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Physiol"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"300060520982657","DOI":"10.1177\/0300060520982657","article-title":"Gastrobiota Group. Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies","volume":"49","author":"Drago","year":"2021","journal-title":"J Int Med Res"},{"key":"R11-20240830","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: History, pathophysiology, clinical features and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"R12-20240830","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000513292","article-title":"Questionnaire-based survey on epidemiology of functional gastrointestinal disorders and current status of gastrointestinal motility testing in Asian countries","volume":"102","author":"Kamiya","year":"2020","journal-title":"Digestion"},{"key":"R13-20240830","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5056\/jnm16214","article-title":"What is new in Rome IV","volume":"23","author":"Schmulson","year":"2017","journal-title":"J Neurogastroenterol Motil"},{"key":"R14-20240830","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","article-title":"Functional dyspepsia","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"R15-20240830","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S2468-1253(18)30003-7","article-title":"Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: A cross-sectional population-based study","volume":"3","author":"Aziz","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"R16-20240830","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/00365521.2020.1761998","article-title":"Prevalence of functional dyspepsia-like symptoms in ulcerative colitis patients in clinical remission and overlap with irritable bowel syndrome-like symptoms","volume":"55","author":"Kotani","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"R17-20240830","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1136\/gutjnl-2014-308114","article-title":"Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria","volume":"64","author":"Fang","year":"2015","journal-title":"Gut"},{"key":"R18-20240830","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.cgh.2021.04.011","article-title":"Overlap of Rome IV irritable bowel syndrome and functional dyspepsia and effect on natural history: A longitudinal follow-up study","volume":"20","author":"Barberio","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R19-20240830","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-230X-8-43","article-title":"The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria","volume":"8","author":"Wang","year":"2008","journal-title":"BMC Gastroenterol"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_369_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:12Z","timestamp":1787839152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_369_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_369_23","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-09-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}