{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:02Z","timestamp":1787775722447,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Atherosclerosis is the main process in coronary artery stenosis, which is exacerbated by vitamin D deficiency. This study aims to investigate the relationship between vitamin D deficiency treatment, lipid profile, and C-reactive protein (CRP) in ischemic heart disease (IHD).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This is a double-blind, randomized clinical trial involving 44 IHD patients with hypovitaminosis, aged 40\u201365 years, who were referred to Chamran Specialty Heart Hospital, Isfahan, Iran. Participants were randomly divided into two groups: The intervention group received weekly doses of 50,000 units of vitamin D\n 3<\/jats:sub>\n for 5 weeks, while the placebo group received a control substance. CRP and serum lipid profiles, including total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), were assessed before and after the intervention. Trial registration number: IRCT20200905048622N1.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age of the IHD patients was 57.84 \u00b1 9.66 years, and among all 44 patients, 40 patients (91%) were male In the intervention group receiving vitamin D\n 3<\/jats:sub>\n , serum levels of HDL (\n P<\/jats:italic>\n = 0.048) and 25-hydroxyvitamin D (25(OH)D) (\n P<\/jats:italic>\n < 0.001) increased, while serum level of TG (\n P<\/jats:italic>\n = 0.008) decreased significantly. In the placebo group, HDL level (\n P<\/jats:italic>\n = 0.007) was increased and alanine transaminase (ALT) (\n P<\/jats:italic>\n = 0.05) was significantly decreased. The results showed that the correlation between serum 25(OH)D treatment and CRP level was not significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Vitamin D supplementation in IHD patients led to notable improvements in lipid profiles, including increased HDL-C levels and decreased TG levels. These findings hold potential clinical implications for healthcare professionals in managing risk factors in IHD patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_380_23","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:00:56Z","timestamp":1727150456000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial"],"prefix":"10.4103","volume":"13","author":[{"given":"Masoumeh","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Momeni","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh S.","family":"Mirsaeidi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Jamalian","sequence":"additional","affiliation":[{"name":"Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Amirpour","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"},{"name":"Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad M.","family":"Hadavi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parsa","family":"Tavassoli","sequence":"additional","affiliation":[{"name":"Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Taheri","sequence":"additional","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Azizi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Rouhani","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Roohafza","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"R1-20240924","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jacc.2022.05.033","article-title":"Cardiovascular disease projections in the United States based on the 2020 census estimates","volume":"80","author":"Mohebi","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"R2-20240924","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.atherosclerosis.2017.07.001","article-title":"C-reactive protein in atherosclerosis\u2013A risk marker but not a causal factor? 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