{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:27Z","timestamp":1786649667232,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While Synchronized Intermittent Mandatory Ventilation with Volume Guarantee (SIMV + VG) is commonly used for mechanical ventilation in preterm infants with respiratory failure, High-Frequency Oscillatory Ventilation (HFOV) is often reserved for cases unresponsive to conventional modes. Given the inconclusive findings on the early HFOV, this trial compares SIMV + VG and HFOV as initial ventilation strategies in preterm infants with respiratory distress syndrome (RDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial included 86 neonates (25\u201335 weeks\u2019 gestation) with RDS, enrolled from 2020 to 2023 at two tertiary referral hospitals affiliated with Isfahan University of Medical Sciences, Iran. Using stratified block randomization by birth weight, neonates were assigned to either the HFOV or SIMV + VG group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 43 each). Primary outcomes included total intubation duration, Non-Invasive Positive Pressure Ventilation (NIPPV) duration, and total oxygen therapy duration. Secondary outcomes included hospitalization duration and the incidence of complications such as Bronchopulmonary Dysplasia (BPD), Intraventricular Hemorrhage (IVH), and Retinopathy of Prematurity (ROP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The HFOV group showed significantly shorter intubation duration (3.80 vs. 8.62 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) and NIPPV duration (5.63 vs. 7.86 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.017), and lower BPD incidence (21.2% vs. 46.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.032). Differences in oxygen therapy, hospitalization duration, and other complications were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early HFOV application in preterm neonates with RDS significantly reduces intubation duration, NIPPV duration, and BPD incidence. These findings suggest potential benefits of HFOV in improving neonatal outcomes. Further multi-center studies with long-term follow-up are warranted to validate these results and explore broader clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_46_25","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T14:01:41Z","timestamp":1767103301000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Elective HFOV vs CMV as Early Intervention: A Clinical Trial in Neonates with Acute Respiratory Distress Syndrome"],"prefix":"10.4103","volume":"14","author":[{"given":"Zohreh","family":"Badiee","sequence":"first","affiliation":[{"name":"Department of Pedatrics, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Saraeian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sadeghnia","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Yazdi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Saraeian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"R1-20251230","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.107.1.e1","article-title":"Very low birth weight outcomes of the national institute of child health and human development neonatal research network, January 1995 through December 1996","volume":"107","author":"Lemons","year":"2001","journal-title":"Pediatrics"},{"key":"R2-20251230","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000499361","article-title":"European consensus guidelines on the management of respiratory distress syndrome\u20132019 update","volume":"115","author":"Sweet","year":"2019","journal-title":"Neonatology"},{"key":"R3-20251230","first-page":"602","article-title":"Goldsmith\u2019s assisted ventilation of the neonate: An Evidence-based approach to newborn respiratory care","author":"Keszler","year":"2022","journal-title":"Elsevier"},{"key":"R5-20251230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(93)90088-C","article-title":"A multicenter randomized trial of high frequency oscillatory ventilation as compared with conventional mechanical ventilation in preterm infants with respiratory failure","volume":"32","author":"Ogawa","year":"1993","journal-title":"Early Hum Dev"},{"key":"R6-20251230","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00431-002-1145-z","article-title":"Early use of high frequency ventilation in the premature neonate","volume":"162","author":"Van","year":"2003","journal-title":"Eur J Pediatr"},{"key":"R7-20251230","first-page":"2","article-title":"Mechanical ventilation in the intensive care unit: A prospective study of indications and factors that affect outcome in a tertiary hospital in Nigeria","volume":"8","author":"Tobi","year":"2017","journal-title":"J Anesth Clin Res"},{"key":"R8-20251230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-015-0843-7","article-title":"Mechanical ventilation modes for respiratory distress syndrome in infants: A systematic review and network meta-analysis","volume":"19","author":"Wang","year":"2015","journal-title":"Crit Care"},{"key":"R9-20251230","doi-asserted-by":"crossref","first-page":"e20183061","DOI":"10.1542\/peds.2018-3061","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"142","author":"Fierson","year":"2018","journal-title":"Pediatrics"},{"issue":"6 Pt 1","key":"R10-20251230","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1542\/peds.98.6.1044","article-title":"The Provo multicenter early high-frequency oscillatory ventilation trial: improved pulmonary and clinical outcome in respiratory distress syndrome","volume":"98","author":"Gerstmann","year":"1996","journal-title":"Pediatrics"},{"key":"R11-20251230","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s001340050789","article-title":"A prospective randomized comparison of conventional mechanical ventilation and very early high frequency oscillatory ventilation in extremely premature newborns with respiratory distress syndrome","volume":"25","author":"Plavka","year":"1999","journal-title":"Intensive Care Med"},{"key":"R12-20251230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.jp.7210527","article-title":"Early high-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation in very low birth weight infants: A pilot study of two ventilation protocols","volume":"21","author":"Durand","year":"2001","journal-title":"J Perinatol"},{"key":"R13-20251230","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/PCC.0b013e318219673e","article-title":"First intention high-frequency oscillatory and conventional mechanical ventilation in premature infants without antenatal glucocorticoid prophylaxis","volume":"13","author":"Salvo","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"R14-20251230","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1542\/peds.107.2.363","article-title":"Prospective randomized multicenter comparison of high-frequency oscillatory ventilation and conventional ventilation in preterm infants of less than 30 weeks with respiratory distress syndrome","volume":"107","author":"Moriette","year":"2001","journal-title":"Pediatrics"},{"key":"R15-20251230","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00134-005-2556-x","article-title":"HFOV in premature neonates: effects on pulmonary mechanics and epithelial lining fluid cytokines. A randomized controlled trial","volume":"31","author":"Vento","year":"2005","journal-title":"Intensive Care Med"},{"key":"R16-20251230","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4187\/respcare.02382","article-title":"High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome","volume":"59","author":"Sun","year":"2014","journal-title":"Respir Care"},{"key":"R17-20251230","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJMoa012750","article-title":"High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight infants","volume":"347","author":"Courtney","year":"2002","journal-title":"N Engl J Med"},{"key":"R18-20251230","first-page":"CD001243","article-title":"Prophylactic nasal continuous positive airway pressure for preventing morbidity and mortality in very preterm infants","volume":"6","author":"Subramaniam","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"R19-20251230","first-page":"CD000104","article-title":"Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants","volume":"2015","author":"Cools","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"R20-20251230","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00431-021-03953-z","article-title":"HFOV vs CMV for neonates with moderate-to-severe perinatal onset acute respiratory distress syndrome (NARDS): A propensity score analysis","volume":"180","author":"Liu","year":"2021","journal-title":"Eur J Pediatr"},{"key":"R21-20251230","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMoa1309220","article-title":"Late outcomes of a randomized trial of high-frequency oscillation in neonates","volume":"370","author":"Zivanovic","year":"2014","journal-title":"N Engl J Med"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_46_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:41Z","timestamp":1786647401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_46_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_46_25","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-01-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}