{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:30Z","timestamp":1787847810813,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Migration of autoreactive T cells into the brain and production of inflammatory cytokines play an undeniable role in the neuronal damage in multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). We investigated the immunomodulatory properties of\n                      <jats:italic toggle=\"yes\">Lavandula angustifolia<\/jats:italic>\n                      (lavender), a medicinal plant, in an EAE model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>EAE was induced in C57BL\/6 mice using the MOG35\u201355 peptide. Mice were divided into control and lavender-treated groups, receiving phosphate-buffered saline or lavender extract (50 or 100 mg\/kg), respectively. Clinical symptoms and body weight were recorded throughout the study, and leukocyte infiltration in brain tissues was evaluated postmortem. Lymphocyte proliferation and cytokine production were assessed using MTT and ELISA assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Lavender-treated mice showed a considerable amelioration in clinical symptoms and weight loss (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), along with reduced brain leukocyte infiltration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Additionally, lavender extract suppressed autoreactive lymphocyte proliferation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) and decreased levels of IFN-\u03b3 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), IL-6 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01 for low dose;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for high dose), and IL-17 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 for low dose;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01 for high dose). Conversely, TGF-\u03b2 levels increased significantly in the treated groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results cleared the immunomodulatory effects of lavender in the EAE model. Thus, this herb could be a new candidate for the reduction of damage induced by dysregulation of the immune system in MS and similar autoimmune situations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_511_24","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:00:44Z","timestamp":1769788844000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Ameliorating Effect of Lavandula Angustifolia on Experimental Autoimmune Encephalomyelitis Symptoms by Modulation of Immune Responses"],"prefix":"10.4103","volume":"15","author":[{"given":"Merat","family":"Mahmoodi","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdollah","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azita","family":"Aghaei","sequence":"additional","affiliation":[{"name":"Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Ramezani","sequence":"additional","affiliation":[{"name":"Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Zainodini","sequence":"additional","affiliation":[{"name":"Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Sedghy","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Pouya","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1]]},"reference":[{"key":"R1-20260205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/2319-4170.128746","article-title":"The essential role of T cells in multiple sclerosis: A reappraisal","volume":"37","author":"Constantinescu","year":"2014","journal-title":"Biomed 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