{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:14Z","timestamp":1787772014482,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Reducing bleeding in lumbar vertebrae fusion surgery is essential to maintain the patient\u2019s hemodynamic stability and create a favorable view. This study aims to compare and contrast the effects of dexmedetomidine and magnesium sulfate on lumbar laminectomy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This double-blind randomized clinical trial was conducted on 70 patient underwent lumbar fusion surgery. They were randomly divided into two groups of 35. After inducing general anesthesia with an infusion pump, the first group (MgSO4 group) received an intravenous injection of 60 mg\/kg of 50% magnesium sulfate, diluted in 100 cc of normal saline, for 15 minutes. In the second group (DEX group), a dexmedetomidine infusion was started before anesthesia with a dose of 1 \u03bcg\/kg every 10 minutes. Dexmedetomidine infusion at a rate of 0.5 \u03bcg\/kg\/hour was continued until the end of the surgical procedure. Systolic and diastolic pressure (SBP, DBP), mean atrial pressure (MAP), heart rate (HR), and SPO2, was recorded before surgery and every 30 minutes during surgery. Also, the intraoperative bleeding and side effect were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results of this study showed that SBP and MAP of the DEX group at 30 and 60 minutes were significantly lower than the MgSO4 group. The DBP of the DEX group was significantly lower than the MgSO4 group only in the 30\n                      <jats:sup>th<\/jats:sup>\n                      minute. Intraoperative bleeding, packed-cell transfusion, tachycardia, and quality of the surgical field were significantly lower in the DEX group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Considering that the administration of DEX has been more effective in controlling intraoperative bleeding and better quality of surgical field, it seems that the administration of DEX is more preferable than MgSO4.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_515_24","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:00:45Z","timestamp":1753941645000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Dexmedetomidine and Magnesium Sulfate Administration in Controlling Intraoperative Bleeding in Lumbar Laminectomy Surgery: A Randomized Clinical Trial"],"prefix":"10.4103","volume":"14","author":[{"given":"Zahra","family":"Rahimi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Nazemroaya","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azim","family":"Honarmand","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Meshkin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asieh","family":"Maghami Mehr","sequence":"additional","affiliation":[{"name":"Department of Statistics, School of Mathematics, Yazd University, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"R1-20250731","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.wneu.2015.05.007","article-title":"Significant blood loss in lumbar fusion surgery for degenerative spine","volume":"84","author":"Huang","year":"2015","journal-title":"World neurosurg"},{"key":"R2-20250731","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.otsr.2017.01.011","article-title":"The further exploration of hidden blood loss in posterior lumbar fusion surgery","volume":"103","author":"Xu","year":"2017","journal-title":"Orthop Traumatol Surg Res"},{"key":"R3-20250731","doi-asserted-by":"crossref","first-page":"E949","DOI":"10.1097\/BRS.0000000000002580","article-title":"The perioperative efficacy and safety of antifibrinolytics in adult spinal fusion surgery: A systematic review and meta-analysis","volume":"43","author":"Lu","year":"2018","journal-title":"Spine (Phine Pa 1976)"},{"key":"R4-20250731","doi-asserted-by":"crossref","first-page":"E267","DOI":"10.1097\/BRS.0000000000002315","article-title":"Effectiveness and safety of batroxobin, tranexamic acid and a combination in reduction of blood loss in lumbar spinal fusion surgery","volume":"45","author":"Nagabhushan","year":"2018","journal-title":"Spine (Phine Pa 1976)"},{"key":"R5-20250731","doi-asserted-by":"crossref","first-page":"e8233","DOI":"10.1097\/MD.0000000000008233","article-title":"Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery: A retrospective study","volume":"96","author":"Ren","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"R6-20250731","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/jdrr.jdrr_54_17","article-title":"Bleeding control measures during oral and maxillofacial surgical procedures: A systematic review","volume":"4","author":"Akolkar","year":"2017","journal-title":"J Dent Res Rev"},{"key":"R7-20250731","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4097\/kja.19259","article-title":"Dexmedetomidine: Present and future directions","volume":"72","author":"Lee","year":"2019","journal-title":"Korean J Anesthesiol"},{"key":"R8-20250731","first-page":"e83967","article-title":"Comparing the effect of clonidine and dexmedetomidine on intraoperative bleeding in spine surgery","volume":"9","author":"Janatmakan","year":"2019","journal-title":"Anesth Pain Med"},{"key":"R9-20250731","doi-asserted-by":"crossref","first-page":"102722","DOI":"10.1016\/j.amjoto.2020.102722","article-title":"Effects of perioperative magnesium sulfate with controlled hypotension on intraoperative bleeding and postoperative ecchymosis and edema in open rhinoplasty","volume":"41","author":"Kosucu","year":"2020","journal-title":"Am J Otolaryngol"},{"key":"R10-20250731","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15171\/apb.2016.012","article-title":"Comparative evaluation of dexmedetomidine and magnesium sulphate on propofol consumption, haemodynamics and postoperative recovery in spine surgery: A prospective, randomized, placebo controlled, double-blind study","volume":"6","author":"Srivastava","year":"2016","journal-title":"Adv Pharm Bull"},{"key":"R11-20250731","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12070-009-0067-8","article-title":"Dexmedetomidine used to provide hypotensive anesthesia during middle ear surgery","volume":"61","author":"Nasreen","year":"2009","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"R12-20250731","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0973-0311.208965","article-title":"Anesthesia management in a giant congenital undifferentiated orbital teratoma: A challenging, rare entity","volume":"18","author":"Vali","year":"2017","journal-title":"Indian Anaesth Forum"},{"key":"R13-20250731","first-page":"e64032","article-title":"Controlled hypotension during rhinoplasty: A comparison of dexmedetomidine with magnesium sulfate","volume":"7","author":"Rokhtabnak","year":"2017","journal-title":"Anesth Pain Med"},{"key":"R14-20250731","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bjan.2014.04.003","article-title":"Comparison between magnesium sulfate and dexmedetomidine in controlled hypotension during functional endoscopic sinus surgery","volume":"65","author":"Bayram","year":"2015","journal-title":"Rev Bras Anestesiol"},{"key":"R15-20250731","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/2045-9912.235124","article-title":"Comparing remifentanil, magnesium sulfate, and dexmedetomidine for intraoperative hypotension and bleeding and postoperative recovery in endoscopic sinus surgery and tympanomastoidectomy","volume":"8","author":"Modir","year":"2018","journal-title":"Med Gas Res"},{"key":"R16-20250731","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.3390\/jcm13113122","article-title":"Efficacy and safety of intravenous magnesium sulfate in spinal surgery: A systematic review and meta-analysis","volume":"13","author":"Campos","year":"2024","journal-title":"J Clin Med"},{"key":"R17-20250731","doi-asserted-by":"crossref","first-page":"59","DOI":"10.21608\/ejhm.2021.209979","article-title":"Comparative evaluation of dexmedetomidine versus magnesium sulphate on the adequacy of hypotensive anesthesia and post-operative recovery for patients undergoing endoscopic transnasal transsphenoidal pituitary tumor resection","volume":"86","author":"Ahmed","year":"2021","journal-title":"Egypt J Hosp Med"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_515_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:24:17Z","timestamp":1787768657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_515_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_515_24","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-10-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}