{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:09Z","timestamp":1786649649042,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psoriasis vulgaris poses health challenges to humans. Despite notable progress in the understanding of disease pathogenesis and the availability of various treatment options, a definitive cure remains elusive. Given the various side effects and high treatment costs, many patients seek natural remedies. This study aimed to assess the effectiveness of novel topical flaxseed oil in individuals with mild to moderate plaque psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The outcomes of topical flaxseed oil were compared with those of betamethasone ointment in a two-arm parallel, randomized, controlled clinical trial involving 60 patients. The participants applied the medication as a thin layer to the skin lesions, massaging it twice a day for 4 weeks. Before and after the intervention, they were assessed using two standard questionnaires: the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Statistical analysis showed that, after 4 weeks, flaxseed oil significantly decreased the PASI score (2.43 \u00b1 1.83 vs. 5.85 \u00b1 5.08,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.001) and enhanced the quality of life of patients (3.47 \u00b1 3.16 vs. 8.48 \u00b1 5.53,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) in comparison to betamethasone ointment. Notably, no side effects were observed in the flaxseed oil group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The outcomes suggest that topical flaxseed oil can be an effective complementary therapy for psoriasis vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_559_24","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T14:01:35Z","timestamp":1767103295000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Flaxseed Oil in Treating Mild to Moderate Psoriasis Vulgaris Compared with Topical Betamethasone: A Randomized, Double-Blind, Clinical Trial"],"prefix":"10.4103","volume":"14","author":[{"given":"Farshad","family":"Mohammadian Rasanan","sequence":"first","affiliation":[{"name":"Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghobadi","sequence":"additional","affiliation":[{"name":"Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoorieh","family":"Mohammadi Kenari","sequence":"additional","affiliation":[{"name":"Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Ghassemi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Research Development Center, Iran University of Medical Sciences (IUMS), Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshanak","family":"Ghods","sequence":"additional","affiliation":[{"name":"Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Taghavi Shirazi","sequence":"additional","affiliation":[{"name":"Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, 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