{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:09:36Z","timestamp":1793045376032,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n The present study was performed to compare the effectiveness of propofol\u2013remifentanil and propofol\u2013hydralazine in inducing controlled hypotension in patients undergoing the dacryocystorhinostomy (DCR) surgery and reducing their bleeding volume during surgery.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The present double-blind, randomized clinical trial was performed on 70 patients who were candidates for DCR surgery and divided into two groups. In both the groups, general anesthesia protocol was performed. Moreover, in the first group, a syringe containing 2 mg of remifentanil in 20 ml of distilled water (0.1 mg\/ml) was infused at the rate of 0.15 \u03bcg\/kg\/min (P + R group). In the second group, a syringe containing 20 mg of hydralazine in 20 ml of distilled water (1 mg\/ml) was infused at the rate of 0.5\u201310 mg\/h (P + H group).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The hemodynamic parameters were not significantly different between the two groups in the studied times (\n P<\/jats:italic>\n > 0.05). In contrast, the bleeding volume in the P + R group with the mean of 61.29 \u00b1 50.06 ml was significantly lower than that of the P + H group with the mean of 152.31 \u00b1 90.81 ml (\n P<\/jats:italic>\n < 0.001). Moreover, the mean score of surgeon's satisfaction level in the P + R group was higher than that of the P + H group (5.91 \u00b1 0.28 vs. 4.29 \u00b1 0.65;\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n According to the results of this study, there was no significant difference between the P + H and P + R groups in terms of fluctuations in the hemodynamic parameters and the occurrence of complications. However, a reduction in the bleeding volume and a higher satisfaction level of the surgeon were observed in the P + R group compared with the P + H group.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_57_22","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:46:14Z","timestamp":1693475174000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Effect of Propofol\u2013Remifentanil and Propofol\u2013Hydralazine on the Bleeding Volume During Dacryocystorhinostomy Surgery Under General Anesthesia"],"prefix":"10.4103","volume":"12","author":[{"given":"Hamidreza","family":"Shetabi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Jalal","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department 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