{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:57Z","timestamp":1787764857004,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n We aimed to investigate the usefulness of intracranial arterial pulsatility index to assess the prognosis of lacunar infarcts.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Forty-nine patients with confirmed acute lacunar infarct were enrolled in the study. A transcranial color-coded sonography was performed to assess the pulsatility index of bilateral middle cerebral, posterior cerebral, vertebral, and proximal internal carotid arteries. Patients' clinical status was assessed using a modified Rankin scale. Spearman correlation was used for reporting the relation between quantitative data. Statistical significance was defined as a two-tail\n p-<\/jats:italic>\n value of less than 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age \u00b1 standard deviation was 64.1 \u00b1 9.07 years old, and 57.1% of the patients were male. Upon discharge, only 8.2% of the patients were ranked as 0 on the modified Rankin scale; however, after a 6-month follow-up period, this number increased to 49%. There were no significant differences between the left and right pulsatility index measurements in any of the assessed arteries. Patients with vertebral artery pulsatility indexes >1 on their primary assessment had significantly worse outcomes during the first, third, and sixth months follow-up (all\n r<\/jats:italic>\n > 0.3,\n p-<\/jats:italic>\n values < 0.01). Pulsatility indexes from other arteries did not predict the prognosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Sonography-assisted assessment of the vertebral artery blood flow during the early stage of lacunar infarct provides a reliable reference for prognosis estimation.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/abr.abr_69_22","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:18:03Z","timestamp":1698373083000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Application of the Intracranial Arterial Pulsatility Index for Determination of Prognosis after Lacunar Infarct"],"prefix":"10.4103","volume":"12","author":[{"given":"Mohammad","family":"Saadatnia","sequence":"first","affiliation":[{"name":"Isfahan Neurosciences Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Zandifar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Isfahan Neurosciences Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Du Ub","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Shafaat","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Octavio","family":"Tierradentro-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Manouchehri","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariborz","family":"Khorvash","sequence":"additional","affiliation":[{"name":"Isfahan Neurosciences Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00685305","article-title":"The arterial lesions underlying lacunes","volume":"12","author":"Fisher","year":"1968","journal-title":"Acta Neuropathol"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"e010460","DOI":"10.1161\/CIRCIMAGING.120.010460","article-title":"Association of white matter hyperintensities and cardiovascular disease: The importance of microcirculatory disease","volume":"13","author":"Moroni","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. 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