{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:24Z","timestamp":1786649664054,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Iron deficiency anemia (IDA) constitutes a worldwide health issue, particularly affecting women of reproductive age. Conventional treatments have limitations and side effects, prompting the exploration of alternative therapies. Siddha system of medicine offers potential remedies with minimal side effects. This trial aims to assess the safety and effectiveness of Thiriloga Chendhuram (TC), a herbometallic preparation from Siddha medicine, in the correction of IDA. The study also seeks to understand TC\u2019s potential mechanisms of action through comprehensive hematological and biochemical investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This is an open-labeled randomized controlled proof-of-concept study with an active control. From SRRI, Puducherry OPD who meet the inclusion criteria are enrolled for this trial. The study site is Siddha Regional Research Institute, Puducherry. Trial participants are randomly assigned to two groups to receive either TC or Annabedhi Chendhuram (ABC-Active Control) at a 1:1 ratio. All the quantitative outcomes will be analyzed using SPSS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>This study is expected to be completed in approximately 12 months, based on recruitment. The results of the study will be published in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This proof-of-concept study addresses the challenges of IDA in women of reproductive age, emphasizing the potential role of Siddha medicine and offering alternatives for managing IDA. This trial also assesses the reticulocyte hemoglobin content (CHr) and percentage of hypochromic cells (% hypo), which offer enhanced sensitivity, specificity, and reliability for diagnosing IDA. The findings will pave the way for future large-scale trials and also contribute to innovative approaches in addressing IDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_74_24","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T14:01:52Z","timestamp":1767103312000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An Open Label, Randomized Control Proof of Concept Study to Compare the Effectiveness of Thiriloga Chendhuram (TC) with Annabedhi Chendhuram (ABC; Active Control) in the Treatment of Veluppu Noi (Iron Deficiency Anemia) in Women of Reproductive Age: A Prospective Double-Arm Clinical Trial Protocol"],"prefix":"10.4103","volume":"14","author":[{"given":"Rajendra K.","family":"Arumugam","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Central Council for Research in Siddha (Ministry of Ayush, Govt. of India), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Gunalan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Annamalai","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Arivazhagan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamala","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Siddha Regional Research Institute (Central Council for Research in Siddha, Ministry of Ayush, Govt. of India), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12]]},"reference":[{"key":"R1-20251230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/nyas.14092","article-title":"Anemia epidemiology, pathophysiology, and etiology in low\u2010and middle\u2010income countries","volume":"1450","author":"Chaparro","year":"2019","journal-title":"Ann N Y Acad Sci"},{"issue":"2018","key":"R3-20251230","first-page":"4157876","article-title":"Prevalence of iron deficiency anemia among university students in Hodeida Province, Yemen","volume":"23","author":"Al-Alimi","year":"2018","journal-title":"Anemia"},{"key":"R6-20251230","doi-asserted-by":"crossref","first-page":"180","DOI":"10.14232\/abs.2022.2.180-191","article-title":"A longitudinal study on the prevalence of iron deficiency anemia in the multiethnic communities of Jhargram, West Bengal","volume":"66","author":"Mandal","year":"2022","journal-title":"Acta Biol Szeged"},{"key":"R7-20251230","doi-asserted-by":"crossref","first-page":"319","DOI":"10.11648\/j.ajhr.20140205.26","article-title":"Prevalence and risk factors of iron deficiency anemia among children in Yemen","volume":"2","author":"Al-Zabedi","year":"2014","journal-title":"Am J Health Res"},{"key":"R8-20251230","doi-asserted-by":"crossref","first-page":"146","DOI":"10.15537\/smj.2015.2.10289","article-title":"The impact of maternal iron deficiency and iron deficiency anemia on child\u2019s health","volume":"36","author":"Abu-Ouf","year":"2015","journal-title":"Saudi Med J"},{"key":"R9-20251230","first-page":"374","article-title":"Evidence-based clinical efficacy of certain indigenous traditional siddha formulations in combating anemia: A global health burden\u2013A systematic review and meta-analysis. 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Arulmigu Pazhani Thandayudhapani Swamy Thirukovil Siddha maruthuva nool Veliyettu Kuzhu","volume":"I","author":"Thiyagarajan","year":"1976","journal-title":"Directorate of Indian Medicine- Homeopathy, Chennai"},{"key":"R13-20251230","first-page":"185","article-title":"Pre-clinical studies of Siddha formulations advocated for anaemia: A systematic review and meta-analysis","volume":"13","author":"Arumugam","year":"2023","journal-title":"J Appl Pharm Sci"},{"key":"R16-20251230","first-page":"1400","article-title":"Acute and chronic toxicological study on Thiriloga Chendooram-a herbo metallic Siddha formulation in Wistar rat","volume":"8","author":"Rajesh","year":"2014","journal-title":"World J Pharm Res."},{"key":"R17-20251230","article-title":"Anaemia control through Ayurveda and Siddha (Background papers) for National Campaign on Anaemia Control through Ayurveda and Siddha","author":"Srikanth","year":"2009"},{"key":"R21-20251230","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4103\/2395-2113.251866","article-title":"Iron deficiency anemia: An insight into new screening parameters","volume":"3","author":"Chhabra","year":"2017","journal-title":"Indian J Community Family Med"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_74_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:44Z","timestamp":1786647404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/abr.abr_74_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/abr.abr_74_24","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2024-02-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}