{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:51Z","timestamp":1787771991400,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D has several physiological functions besides its well-known role in the hemostasis of calcium. There are many contradictory reports about vitamin D deficiency in hypothyroid patients, showing the relation is not conclusive. In this study, we focused on vitamin D\u2013deficient individuals and clarified whether a thyroid dysfunction or calcium imbalance was present. The results are interpreted and discussed according to different vitamin D deficiency criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Clinical data of a total of 772 people who were referred to the laboratory for their routine care were collected for one year. They had preprescribed tests for T4, TSH, calcium, and vitamin D. Subjects were sorted into vitamin D deficiency, insufficiency, and sufficiency groups based on their vitamin D levels. Mean levels of thyroid hormones, calcium, and age were compared between groups, and their correlations were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the participants, 74.2% had vitamin D deficiency or insufficiency. No difference in calcium levels was observed between the groups. T4 levels increased significantly, and TSH decreased nonsignificantly with increasing vitamin D levels. However, changes in T4 and TSH levels were within the reference ranges. Vitamin D levels were nonsignificantly correlated with T4 and negatively with TSH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D deficiency could not cause thyroid function and serum calcium levels to walk out of the reference ranges. It seems that in our study conditions, vitamin D deficiency does not cause obvious hypothyroidism and hypocalcemia. Part of this discrepancy seems to be related to the current vitamin D reference intervals, which should be revised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_7_23","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T06:00:23Z","timestamp":1753941623000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Normocalcemia and Normal Thyroid Function in a Severe Vitamin D\u2013Deficient Population"],"prefix":"10.4103","volume":"14","author":[{"given":"Omid","family":"Yazdani","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Haeri","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhaneh","family":"Niayesh-Mehr","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"R1-20250731","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ecl.2017.07.002","article-title":"Global overview of vitamin D status","volume":"46","author":"Van Schoor","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R2-20250731","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3945\/an.117.015578","article-title":"25-Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population","volume":"8","author":"Cashman","year":"2017","journal-title":"Adv Nutr"},{"key":"R3-20250731","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur J Clin Nutr"},{"key":"R4-20250731","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3122\/jabfm.2009.06.090037","article-title":"Vitamin D: An evidence-based review","volume":"22","author":"Kulie","year":"2009","journal-title":"J Am Board Fam Med"},{"key":"R5-20250731","first-page":"111","article-title":"Vitamin D and endocrine disorders: Routine laboratory diagnostic implications","volume":"29","author":"Muscogiuri","year":"2018","journal-title":"EJIFCC"},{"key":"R6-20250731","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3390\/ijms18091949","article-title":"The role of vitamin D in thyroid diseases","volume":"18","author":"Kim","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R7-20250731","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3390\/nu12051444","article-title":"Immunomodulatory effects of vitamin D in thyroid diseases","volume":"12","author":"Mele","year":"2020","journal-title":"Nutrients"},{"key":"R8-20250731","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12902-021-00897-1","article-title":"Association between vitamin D deficiency and hypothyroidism: Results from the National Health and Nutrition Examination Survey (NHANES) 2007\u20132012","volume":"21","author":"Appunni","year":"2021","journal-title":"BMC Endocr Disord"},{"key":"R9-20250731","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2147\/RMHP.S269640","article-title":"Associations between serum 25-hydroxyvitamin D levels and thyroid function parameters in previously healthy children aged 6 to 24 months","volume":"13","author":"Guo","year":"2020","journal-title":"Risk Manag Healthc Policy"},{"key":"R10-20250731","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3889\/oamjms.2017.029","article-title":"No association between 25 (OH) vitamin D level and hypothyroidism among females","volume":"5","author":"Musa","year":"2017","journal-title":"Open Access Maced J Med Sci"},{"key":"R11-20250731","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1515\/jpem-2015-0210","article-title":"Absence of a relationship between thyroid hormones and vitamin D levels","volume":"29","author":"Zhou","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R12-20250731","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJMcp1009570","article-title":"Clinical practice. 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