{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:03Z","timestamp":1787071563618,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Laparoscopic cholecystectomy is the standard surgical procedure in symptomatic gallstones. Laparoscopy is a minimally invasive surgical method. The aim of the present study was to investigate the effect of dexamethasone (DX) administration on postoperative pain management following laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>165 patients with laparoscopic cholecystectomy surgery were studied in this double-blind clinical trial. They were randomly divided into three groups: A) DX1 (Intravenous DX): Injection of 0.1 mg\/kg DX intravenously, B) DX2 (Local DX): Injection of 0.1 mg\/kg of DX, diluted with normal saline, injection volume of 10 mL, injection into the bed of the removed gallbladder through a laparoscopic 10 mm subxiphoid trocar, and C) Control: Injection of placebo, the volume and injection site are similar to group B. The amount of postoperative pain in patients was recorded using the Visual Analogue Scale score in 5 times (15 minutes, 30 minutes, 1 hour, 6 hours, and 12 hours after entering the recovery room).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In terms of postoperative pain, there was a statistically significant difference between the studied groups so that the amount of postoperative pain 6 hours and 12 hours after surgery in the intravenous DX group was lower than that in the local DX and placebo groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results of this study showed that the administration of intravenous DX has a better effect than the administration of local DX in pain management after laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/abr.abr_9_25","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:00:41Z","timestamp":1759132841000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Dexamethasone Administration on Postoperative Pain Following Laparoscopic Cholecystectomy: A Double-Blind Randomized Clinical Trial"],"prefix":"10.4103","volume":"14","author":[{"given":"Ali","family":"Ghomeishi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Department of 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