{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:42Z","timestamp":1787840622104,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this study was to assess whether parasternal block with multihole catheters inserted before surgical incision enables to alleviate postoperative analgesia and opioid reduction in cardiac surgery patients with sternotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-six adult patients scheduled for cardiac surgery with sternotomy aged between 18 and 84 olds were included in this prospective, monocentric, open, single-group trial. Two parasternal multihole catheters were inserted on each side of the sternum before the surgical skin incision for cardiac surgery and 10 mL of ropivacaine 7.5 mg mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      was initially administered in each catheter. Local anesthetic administration followed by continued infusion at 3 mL hr\n                      <jats:sup>\u20131<\/jats:sup>\n                      of ropivacaine 2 mg mL\n                      <jats:sup>\u20131<\/jats:sup>\n                      per catheter for 48 h postoperatively upon patient arrival in the intensive care unit. The efficacy of the parasternal block was assessed according to a composite endpoint including pain score at rest, pain score during movements (dynamic pain), and morphine consumption over 48 hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The treatment failed in 11 patients and was considered effective in 15 patients. Sixteen patients out of 26 had a sternal pain score \u2264\u22643\/10 on more than 75% of observations, and the treatment was considered successful. In 23\/26 patients (88%), the mean pain score at cough was \u2264\u22643.5\/10 and the treatment was considered successful. Morphine consumption over 48 h was significantly lower in the intervention group compared to the control group 7 mg [6; 21] versus 142 mg [116; 176] (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Parasternal block with multihole catheters inserted before the surgical incision is an effective technique for postoperative analgesia and opioid reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_110_24","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T03:00:16Z","timestamp":1732158016000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Benefits of Parasternal Block with Multihole Catheters when Inserted before Sternotomy"],"prefix":"10.4103","volume":"28","author":[{"given":"Vedat","family":"Eljezi","sequence":"first","affiliation":[{"name":"Department of Perioperative Medicine, CHU Gabriel-Montpied, Rue Montalembert, BP 69, 63003 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crispin","family":"Jallas","sequence":"additional","affiliation":[{"name":"Departement of Anaesthesia, H\u00f4spital Femme M\u00e8re Enfant, 59 Boulevard Pinel, 69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, CHU Gabriel Montpied, Rue Montalembert, BP 69, 63003 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Chasteloux","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine, CHU Gabriel-Montpied, Rue Montalembert, BP 69, 63003 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dual\u00e9","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique (INSERM CIC 501), CHU de Clermont-Ferrand, Rue Montalembert, BP 69, 63003, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, CHU Gabriel Montpied, Rue Montalembert, BP 69, 63003 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"R1-20250124","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2147\/JPR.S162067","article-title":"Assessment and pathophysiology of pain in cardiac surgery","volume":"11","author":"Zubrzycki","year":"2018","journal-title":"J Pain Res"},{"key":"R2-20250124","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4103\/aca.ACA_186_17","article-title":"The efficacy of different modes of analgesia in postoperative pain management and early mobilization in postoperative cardiac surgical patients:A systematic review","volume":"21","author":"Nachiyunde","year":"2018","journal-title":"Ann Card Anaesth"},{"key":"R3-20250124","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/10892532211041320","article-title":"Persistent pain after cardiac surgery:Prevention and management","volume":"25","author":"Krakowski","year":"2021","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"R4-20250124","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1053\/j.jvca.2020.09.103","article-title":"Reducing opioid use in patients undergoing cardiac surgery-preoperative, intraoperative, and critical care strategies","volume":"35","author":"Ochroch","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R5-20250124","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.anrea.2022.10.008","article-title":"R\u00e9habilitation am\u00e9lior\u00e9e apr\u00e8s chirurgie cardiaque adulte sous CEC ou \u00e0c\u0153ur battant 2021","volume":"8","author":"Mertes","year":"2022","journal-title":"Anesth R\u00e9anim"},{"key":"R6-20250124","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ccc.2020.06.003","article-title":"Postoperative multimodal analgesia in cardiac surgery","volume":"36","author":"Barr","year":"2020","journal-title":"Crit Care Clin"},{"key":"R7-20250124","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1001\/jamasurg.2019.1153","article-title":"Guidelines for perioperative care in cardiac surgery:Enhanced recovery after surgery society recommendations","volume":"154","author":"Engelman","year":"2019","journal-title":"JAMA Surg"},{"key":"R8-20250124","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1213\/ANE.0000000000004682","article-title":"Regional anesthesia in cardiac surgery:An overview of fascial plane chest wall blocks","volume":"131","author":"Kelava","year":"2020","journal-title":"Anesth Analg"},{"key":"R9-20250124","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/ACO.0000000000000769","article-title":"Regional anesthesia for cardiac surgery","volume":"32","author":"Caruso","year":"2019","journal-title":"Curr Opin Anaesthesiol"},{"key":"R10-20250124","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bpa.2019.02.003","article-title":"Thoracic wall blocks:From paravertebral to retrolaminar to serratus to erector spinae and back again-A review of evidence","volume":"33","author":"Chin","year":"2019","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"R11-20250124","doi-asserted-by":"crossref","first-page":"1716365","DOI":"10.1155\/2019\/1716365","article-title":"Transversus thoracis muscle plane block","volume":"2019","author":"Fujii","year":"2019","journal-title":"Biomed Res Int"},{"key":"R12-20250124","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1053\/j.jvca.2020.03.014","article-title":"Ultrasound parasternal block as a novel approach for cardiac sternal surgery:Could it be the safest strategy?","volume":"34","author":"Sepolvere","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R13-20250124","doi-asserted-by":"crossref","first-page":"382","DOI":"10.23736\/S0375-9393.20.15271-4","article-title":"Fascial plane blocks in cardiac surgery:A future to discover","volume":"87","author":"Sepolvere","year":"2021","journal-title":"Minerva Anestesiol"},{"key":"R14-20250124","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/AAP.0b013e318240957f","article-title":"The analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery","volume":"37","author":"Eljezi","year":"2012","journal-title":"Reg Anesth Pain Med"},{"key":"R15-20250124","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/EJA.0000000000000564","article-title":"Bilateral sternal infusion of ropivacaine and length of stay in ICU after cardiac surgery with increased respiratory risk:A randomised controlled trial","volume":"34","author":"Eljezi","year":"2017","journal-title":"Eur J Anaesthesiol"},{"key":"R16-20250124","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/AAP.0000000000000577","article-title":"Local anesthetic diffusion of bilateral sternal block after cardiac surgery","volume":"42","author":"Eljezi","year":"2017","journal-title":"Reg Anesth Pain Med"},{"key":"R17-20250124","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/bmb\/ldh030","article-title":"Pre-emptive analgesia","volume":"71","author":"Dahl","year":"2004","journal-title":"Br Med Bull"},{"key":"R18-20250124","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1213\/ANE.0b013e318277a270","article-title":"Preventive analgesia by local anesthetics:The reduction of postoperative pain by peripheral nerve blocks and intravenous drugs","volume":"116","author":"Barreveld","year":"2013","journal-title":"Anesth Analg"},{"key":"R19-20250124","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejca.2008.10.029","article-title":"Optimising the design of phase II oncology trials:The importance of randomisation","volume":"45","author":"Ratain","year":"2009","journal-title":"Eur J Cancer"},{"key":"R20-20250124","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1039\/C5EM00084J","article-title":"Quantitative structure-activity relationship correlation between molecular structure and the Rayleigh enantiomeric enrichment factor","volume":"17","author":"Jammer","year":"2015","journal-title":"Environ Sci Process Impacts"},{"key":"R21-20250124","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1378\/chest.118.2.391","article-title":"Pain location, distribution, and intensity after cardiac surgery","volume":"118","author":"Mueller","year":"2000","journal-title":"Chest"},{"key":"R22-20250124","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/AAP.0000000000000607","article-title":"Transversus thoracic muscle plane block on a cadaver with history of coronary artery bypass grafting","volume":"42","author":"Fujii","year":"2017","journal-title":"Reg Anesth Pain Med"},{"key":"R23-20250124","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/rapm-2019-100872","article-title":"Bilateral ultrasound-guided parasternal block for postoperative analgesia in cardiac surgery:Could it be the safest strategy?","volume":"45","author":"Sepolvere","year":"2020","journal-title":"Reg Anesth Pain Med"}],"container-title":["Annals of Cardiac Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.aca_110_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:04Z","timestamp":1787837164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.aca_110_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aca.aca_110_24","relation":{},"ISSN":["0971-9784","0974-5181"],"issn-type":[{"value":"0971-9784","type":"print"},{"value":"0974-5181","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"2024-05-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}