{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:36Z","timestamp":1787071116661,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study was undertaken to determine the effects of dexmedetomidine on pulmonary artery pressure (PAP) in children with congenital heart disease (CHD) and pulmonary hypertension (PH) undergoing cardiac catheterization with and without a planned intervention during monitored anesthetic care using midazolam and ketamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Children (&lt;18 years) with known CHD and PH who were scheduled for cardiac catheterization and interventional procedures were included in the study. The procedures were performed under monitored anesthesia. After obtaining baseline PAPs, an intravenous (IV) infusion of dexmedetomidine (1 \u03bcg\/kg) was given for over 10 min. During infusion, heart rate (HR), blood pressure (BP), respiratory rate (RR), and peripheral arterial oxygen saturation (SPO\n                      <jats:sub>2<\/jats:sub>\n                      ) were recorded every 2 min until completion of dexmedetomidine infusion, 15 min later, and when the procedure was completed. In addition, pulmonary artery systolic and diastolic pressures, and mean pulmonary artery pressure (MPAP) were recorded and the pulmonary artery systolic pressure (PASP)\/systolic blood pressure (BP) ratio was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All children tolerated the procedure without adverse events. The HR decreased significantly over time during dexmedetomidine infusion. The changes in systemic systolic BP and PAPs were not significantly different from the baseline value at all points of measurement as was the ratio between the systolic pulmonary artery and systolic systemic BPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Administration of dexmedetomidine in a dose of 1 \u03bcg\/kg over 10 min did not significantly alter the PAP in children with CHD and PH. There was a decrease in the HR that was not clinically significant. The children tolerated dexmedetomidine without adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_115_19","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T07:18:01Z","timestamp":1613114281000},"page":"465-470","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Dexmedetomidine on Pulmonary Artery Pressure in Children with Congenital Heart Disease and Pulmonary Hypertension"],"prefix":"10.4103","volume":"23","author":[{"given":"Muralidhar","family":"Kanchi","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Narayana Institute of Cardiac Sciences, Narayana Health City, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devdas Thomas","family":"Inderbitzin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadam Naina","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Narayana Institute of Cardiac Sciences, Narayana Health City, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujar Venkateshauarya","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Narayana Institute of Cardiac Sciences, Narayana Health City, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreesha Shankar","family":"Mayya","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Narayana Institute of Cardiac Sciences, Narayana Health City, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanthi","family":"Sivanandam","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Belani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"R1-20250921","first-page":"183","article-title":"Intracardiac valvulotomy by means of a catheter","volume":"23","author":"Rubio-Alvarez","year":"1953","journal-title":"Arch Inst Cardiol Mex"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.CIR.38.3.453","article-title":"Transposition of the great arteries. Results of palliation by balloon atrioseptostomy in thirty-one infants","volume":"38","author":"Rashkind","year":"1968","journal-title":"Circulation"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2044.1954.tb01498.x","article-title":"Anaesthesia for cardiac catheterisation in children","volume":"9","author":"Inglis","year":"1954","journal-title":"Anaesthesia"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00000542-195703000-00013","article-title":"Anesthesia for cardiac catheterization in infants and children","volume":"18","author":"Keown","year":"1957","journal-title":"Anesthesiology"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF03015575","article-title":"Sedation of children for cardiac catheterization with an atretic mixture","volume":"5","author":"Smith","year":"1958","journal-title":"Can Anaesth Soc J"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/bja\/88.2.241","article-title":"Depth of sedation in children undergoing computed tomography: Validity and reliability of the University of Michigan Sedation Scale (UMSS)","volume":"88","author":"Malviya","year":"2002","journal-title":"Br J Anaesth"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00000542-200011000-00030","article-title":"Clinical uses of \u03b12-adrenergic agonists","volume":"93","author":"Kamibayashi","year":"2000","journal-title":"Anesthesiology"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00003495-200059020-00012","article-title":"Dexmedetomidine","volume":"59","author":"Bhana","year":"2000","journal-title":"Drugs"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1460-9592.2005.01418.x","article-title":"Dexmedetomidine as the primary sedative agent for brain radiation therapy in a 21-month old child","volume":"15","author":"Shukry","year":"2005","journal-title":"Paediatr Anaesth"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00000542-199212000-00013","article-title":"Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate","volume":"77","author":"Belleville","year":"1992","journal-title":"Anesthesiology"},{"key":"R12-20250921","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1460-9592.2005.01656.x","article-title":"Prolonged infusion of dexmedetomidine for sedation following tracheal resection","volume":"15","author":"Hammer","year":"2005","journal-title":"Pediatr Anesth"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00007611-200405000-00007","article-title":"Sedation during mechanical ventilation in infants and children: Dexmedetomidine versus midazolam","volume":"97","author":"Tobias","year":"2004","journal-title":"South Med J"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/PCC.0b013e31818d320d","article-title":"Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease","volume":"9","author":"Barton","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"R15-20250921","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s00246-012-0211-1","article-title":"Is the addition of dexmedetomidine to a ketamine\u2013propofol combination in pediatric cardiac catheterization sedation useful?","volume":"33","author":"Ulgey","year":"2012","journal-title":"Pediatr Cardiol"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MJT.0b013e3180a72255","article-title":"Monitored anesthesia care with a combination of ketamine and dexmedetomidine during cardiac catheterization","volume":"15","author":"Mester","year":"2008","journal-title":"Am J Ther"},{"key":"R17-20250921","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1053\/j.jvca.2005.07.018","article-title":"Dexmedetomidineketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization","volume":"2","author":"Tosun","year":"2006","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R18-20250921","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/pan.12687","article-title":"Intranasal dexmedetomidine for sedation in children undergoing transthoracic echocardiography study-a prospective observational study","volume":"25","author":"Li","year":"2015","journal-title":"Pediatr Anesth"},{"key":"R19-20250921","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1213\/01.ANE.0000219592.82598.AA","article-title":"A comparison of the sedative, hemodynamic, and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging","volume":"103","author":"Koroglu","year":"2006","journal-title":"Anesth Analg"},{"key":"R20-20250921","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1213\/01.ane.0000287656.29064.89","article-title":"Ketamine does not increase pulmonary vascular resistance in children with pulmonary hypertension undergoing sevoflurane anesthesia and spontaneous ventilation","volume":"105","author":"Williams","year":"2007","journal-title":"Anesth Analg"},{"key":"R21-20250921","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1213\/ANE.0b013e3182a15aa6","article-title":"The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension","volume":"117","author":"Friesen","year":"2013","journal-title":"Anesth Analg"},{"key":"R22-20250921","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/PCC.0b013e3181ceae7d","article-title":"Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study","volume":"11","author":"Lazol","year":"2010","journal-title":"Pediatr Crit Care Med"},{"key":"R23-20250921","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0259-1162.84193","article-title":"Dexmedetomidine premedication in relevance to ketamine anesthesia: A prospective study","volume":"5","author":"Gupta","year":"2011","journal-title":"Anesth Essays Res"}],"container-title":["Annals of Cardiac Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.ACA_115_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:43Z","timestamp":1787067703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.ACA_115_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/aca.aca_115_19","relation":{},"ISSN":["0971-9784","0974-5181"],"issn-type":[{"value":"0971-9784","type":"print"},{"value":"0974-5181","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"2019-08-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}