{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:32Z","timestamp":1787169512886,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Left atrial volume indexed to body surface area (LAVi) is the recommended method for LA size quantification. Assessing LAVi in Indian patients undergoing coronary interventions for acute coronary syndrome (STEMI, NSTEMI, and UA) is clinically relevant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Amongst 190 patients (66.4 yrs, 68.4% males), 29.5%, 40.5%, and 30% respectively had STEMI, NSTEMI and UA. Mean LAVi was 32.29 \u00b1 12.06 ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      and 111 (58.4%) had LAVi \u226532 while 79 (41.6%) had LAVi &lt;32. Patients were divided into 2 groups (group 1 LAVi &gt;32 and group 2 LAVi &lt;32). Group 1 patients had higher prevalence of TVD [\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 49 vs\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = &lt;0.001] and higher mean Syntax score (24.47 vs 14.64,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = &lt;0.001). Despite similar LVEF, those with higher LAVi had had higher incidence of mild MR (50.4 vs 27.8,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0002) and moderate\/severe MR was present only in Group 1 patients (27.9% and 5.4%). Grade I, II, and III diastolic dysfunction was present in 71.2, 17.1, and 9.9% patients in Group 1 vs 45.6%, 0%, and 0% in group 2. Diastolic parameters like septal E\/e' and lateral E\/e'ratio were also higher in Group 1. Major adverse cardiovascular events (MACE) at 30 days was significantly higher in group 1 (20.7 vs 6.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006). On multivariate analysis, triple vessel disease and LAVi were the only predictors of MACE while LVEF was not. ROC curve analysis for LAVi demonstrated that a cut-off 33.35 ml\/m2, predicted 30 day MACE with Area under curve (AUC) 0.775 (95% CI 0.700-0.850); sensitivity and specificity of 86.7% and 61.4%. Inter-quartile analysis of LAVi (&lt;26.3, 26.3-33.35, 33.36-36.3, and &gt;36.3 ml\/m2) demonstrated that 30 day MACE increased across quartiles (4.16%, 4.25%, 22.44%, and 28.26%, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Amongst patients with ACS undergoing revascularization, those with higher LAVi had more severe CAD, diastolic dysfunction and higher 30 day MACE. LAVi provides superior prognostic information as compared to conventional LV systolic and diastolic parameters in patients with ACS and should be incorporated in routine echocardiographic analysis. More studies with larger numbers and longer follow up are required to further elucidate on this.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_129_20","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T13:32:18Z","timestamp":1642771938000},"page":"19-25","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Is Indexed Left Atrial Volume (LAVi) in Indian Patients with Acute Coronary Syndrome (ACS) Undergoing Revascularization a Predictor of Cardiovascular Outcomes?"],"prefix":"10.4103","volume":"25","author":[{"given":"Abhishek","family":"Saklecha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopali","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyendra","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240901","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/ejechocard\/jer137","article-title":"Working Group on Echocardiography of the Italian Society of Cardiology: Determinants of echocardiographic left atrial volume: Implications for normalcy","volume":"12","author":"Nistri","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"R2-3-20240901","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"R3-3-20240901","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.89.2.724","article-title":"Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham heart study","volume":"89","author":"Vaziri","year":"1994","journal-title":"Circulation"},{"key":"R4-3-20240901","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0002-9149(01)01460-6","article-title":"M-mode echocardiographic predictors of six- to seven-year incidence of coronary heart disease, stroke, congestive heart failure, and mortality in an elderly cohort (the Cardiovascular Health Study)","volume":"87","author":"Gardin","year":"2001","journal-title":"Am J Cardiol"},{"key":"R5-3-20240901","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4065\/79.8.1008","article-title":"Left atrial volume in the prediction of first ischemic stroke in an elderly cohort without atrial fibrillation","volume":"79","author":"Barnes","year":"2004","journal-title":"Mayo Clin Proc"},{"key":"R6-3-20240901","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/01.CIR.92.4.835","article-title":"Left atrial size and the risk of stroke and death. The Framingham Heart Study","volume":"92","author":"Benjamin","year":"1995","journal-title":"Circulation"},{"key":"R7-3-20240901","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.amjcard.2005.05.031","article-title":"Usefulness of left atrial volume in predicting first congestive heart failure in patients \u226565 years of age with well-preserved left ventricular systolic function","volume":"96","author":"Takemoto","year":"2005","journal-title":"Am J Cardiol"},{"key":"R8-3-20240901","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.amjcard.2005.07.126","article-title":"Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons\u226565 years of age (the Cardiovascular Health Study)","volume":"97","author":"Gottdiener","year":"2006","journal-title":"Am J Cardiol"},{"key":"R9-3-20240901","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1161\/01.CIR.0000066318.21784.43","article-title":"Left atrial volume: A powerful predictor of survival after myocardial infarction","volume":"107","author":"M\u00f8ller","year":"2003","journal-title":"Circulation"},{"key":"R10-3-20240901","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jacc.2004.03.062","article-title":"Long-term prognostic significance of left atrial volume in acute myocardial infarction","volume":"44","author":"Beinart","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"R11-3-20240901","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/eurheartj\/ehn499","article-title":"Left atrial remodeling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: The VALIANT Echo study","volume":"30","author":"Meris","year":"2009","journal-title":"Heart J"},{"key":"R12-3-20240901","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjcard.2008.02.099","article-title":"Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study)","volume":"102","author":"Ristow","year":"2008","journal-title":"Am Cardiol"},{"key":"R13-3-20240901","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/ejechocard\/jer058","article-title":"Prognostic value of left atrial volume index in patients with first acute myocardial infarction","volume":"12","author":"Sakaguchi","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"R14-3-20240901","doi-asserted-by":"crossref","first-page":"997","DOI":"10.6061\/clinics\/2013(07)18","article-title":"Assessment of the left atrial volume index and plasma NT-proANP level in patients with acute ST-elevation myocardial infarction","volume":"68","author":"Bacaksiz","year":"2013","journal-title":"Clinics (Sao Paulo"},{"key":"R15-3-20240901","first-page":"18","article-title":"The Executive Group on behalf of the Joint European Society of Cardiology (ESC)\/American College of Cardiology (ACC)\/American Heart Association (AHA)\/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"R16-3-20240901","first-page":"282","article-title":"Left atrial volume index and prediction of events in acute coronary syndrome: Solar registry","volume":"103","author":"Secundo Junior","year":"2014","journal-title":"Arq Bras Cardiol"},{"key":"R17-3-20240901","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cjca.2012.02.015","article-title":"Left atrial volume index is an independent predictor of major adverse cardiovascular events in acute coronary syndrome","volume":"28","author":"Gunasekaran","year":"2012","journal-title":"Can J Cardiol"},{"key":"R18-3-20240901","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.mayocp.2015.07.021","article-title":"Prediction of all-cause mortality by the left atrial volume index in patients with normal left ventricular filling pressure and preserved ejection fraction","volume":"90","author":"Patel","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"R19-3-20240901","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0002-9149(02)02864-3","article-title":"Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden","volume":"90","author":"Tsang","year":"2002","journal-title":"Am J Cardiol"},{"key":"R20-3-20240901","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0735-1097(03)00956-2","article-title":"The left atrium: A biomarker of chronic diastolic dysfunction and cardiovascular disease risk","volume":"42","author":"Douglas","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R21-3-20240901","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12947-016-0077-0","article-title":"Prognostic Value of New Left Atrial Volume Index Severity Partition Prognostic value of new left atrial volume index severity partition cutoffs after cardiac rehabilitation program in patients undergoing cardiac surgery","volume":"14","author":"Lazzeroni","year":"2016","journal-title":"Cardiovasc Ultrasound"},{"key":"R22-3-20240901","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.jacc.2006.02.048","article-title":"Left atrial size: Physiologic determinants and clinical applications","volume":"47","author":"Abhayaratna","year":"2006","journal-title":"J Am Coll Cardiol"}],"container-title":["Annals of Cardiac Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.ACA_129_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:42Z","timestamp":1787166462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.ACA_129_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/aca.aca_129_20","relation":{},"ISSN":["0971-9784"],"issn-type":[{"value":"0971-9784","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}