{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:46:36Z","timestamp":1791985596284,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Context:<\/jats:title>\n Mean arterial pressure targets during cardiopulmonary bypass remain debated; vasopressor-driven pressure augmentation may not improve oxygen delivery.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n The aim of the paper is to describe clinical outcomes and physiologic markers during normothermic cardiopulmonary bypass managed with indexed flow, cerebral oximetry, calculated indexed oxygen delivery (DO\n 2<\/jats:sub>\n i), and vasopressor-sparing pressure management.\n <\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n Single-center retrospective descriptive cohort study at a cardiac surgery center.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods:<\/jats:title>\n \n Consecutive adults undergoing elective or urgent cardiac surgery with normothermic cardiopulmonary bypass from June 2023 to December 2025 were included if complete anesthesia\u2013perfusion, regional cerebral oxygen saturation (rSO\n 2<\/jats:sub>\n ), circuit-derived venous oxygen saturation (SvO\n 2<\/jats:sub>\n ), DO\n 2<\/jats:sub>\n i, and early outcome data were available. Circulatory arrest was excluded. Indexed pump flow was 2.2\u20132.4 L\/min\/m\u00b2. Mean arterial pressure was interpreted with indexed flow, rSO\n 2<\/jats:sub>\n , SvO\n 2<\/jats:sub>\n , DO\n 2<\/jats:sub>\n i, hemoglobin, acid\u2013base status, venous return, and surgical context. Baseline rSO\n 2<\/jats:sub>\n was recorded before ventilation on room air; maximal relative decrease during bypass was recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n Descriptive statistics and Wilson 95% confidence intervals were used. No comparative testing or causal modeling was performed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Two hundred patients were analyzed. Operating-room extubation was achieved in 172 patients (86.0%). Stroke occurred in six (3.0%), acute kidney injury in two (1.0%), and venoarterial extracorporeal membrane oxygenation was required in six (3.0%). Baseline right and left rSO\n 2<\/jats:sub>\n were 57.5 \u00b1 11.2% and 58.5 \u00b1 11.3%; maximal relative rSO\n 2<\/jats:sub>\n decrease was 28.5 \u00b1 3.4%; circuit-derived SvO\n 2<\/jats:sub>\n was 67.4 \u00b1 5.9%; and calculated DO\n 2<\/jats:sub>\n i was 611 \u00b1 74 mL\/min\/m\u00b2.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n This flow-oriented, cerebral oximetry-guided, oxygen-delivery-aware strategy was accompanied by favorable early recovery. Because the study was retrospective and noncomparative, the findings are hypothesis-generating.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aca.aca_170_26","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:00:10Z","timestamp":1791824410000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Oxygenation-Guided Indexed-Flow Normothermic Cardiopulmonary Bypass with Vasopressor-Sparing Pressure Management: A Retrospective Descriptive Cohort Study"],"prefix":"10.4103","volume":"29","author":[{"given":"Nikita","family":"Chibisov","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive, Botkin Hospital, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Kornienko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive, Botkin Hospital, Moscow, 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