{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:41Z","timestamp":1787762021747,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Congenital heart surgeries are associated with post-bypass renal and cardiac dysfunctions. The use of low-dose vasopressin has been found to be beneficial in adult cardiac surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the hemodynamic and renal effects of patients undergoing on-pump pediatric cardiac surgery under general anesthesia (GA) with low-dose vasopressin infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective randomized controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Operation room and ICU, tertiary care teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Fifty-five pediatric cardiac patients undergoing repair for congenital heart diseases (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Low-dose vasopressin infusion in the study group and placebo in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results:<\/jats:title>\n                    <jats:p>Renal near-infrared spectroscopy (NIRS), serum NGAL, and inflammatory mediators\u2014IL6 and IL8 along with other renal and hemodynamic parameters in the perioperative period were recorded. Diastolic blood pressure (DBP) and cardiac index were significantly higher in the vasopressin group. Inflammatory markers were significantly high in the immediate postoperative period in all patients which later stabilized in the next 48 h but showed similar trends in both groups. Low-dose vasopressin infusion did not improve either renal perfusion or function. The duration of mechanical ventilation and length of hospital stay, the incidence of AKI development, and transfusion requirements were marginally lower in the vasopressin group, although not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Low-dose vasopressin infusion improved hemodynamics and showed a decreased incidence of complications. However, it failed to show any benefit of renal function and overall outcome in pediatric cardiac surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_182_22","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T17:56:30Z","timestamp":1689011790000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Low-Dose Vasopressin and Renal Perfusion in Pediatric Cardiac Surgery"],"prefix":"10.4103","volume":"26","author":[{"given":"Alok","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Critical Care, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpinder S.","family":"Ghotra","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, Army Institute of Cardiothoracic Sciences, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeth","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HR","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"R1-20240901","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/00003246-199906000-00033","article-title":"Low systemic vascular resistance state in patients undergoing cardiopulmonary bypass","volume":"27","author":"Kristof","year":"1999","journal-title":"Crit Care Med"},{"key":"R2-20240901","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/CCM.0b013e31821201d3","article-title":"Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study","volume":"39","author":"Li","year":"2011","journal-title":"Crit Care Med"},{"key":"R3-20240901","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1749-8090-5-17","article-title":"Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind randomized study","volume":"5","author":"Papadopoulos","year":"2010","journal-title":"J Cardiothorac Surg"},{"key":"R4-20240901","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0003-4975(02)04408-9","article-title":"A double-blind randomized trial: Prophylactic vasopressin reduces hypotension after cardiopulmonary bypass","volume":"75","author":"Morales","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"R5-20240901","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/CCM.0b013e318169245a","article-title":"Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock","volume":"36","author":"Wheeler","year":"2008","journal-title":"Crit Care Med"},{"key":"R6-20240901","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1053\/j.jvca.2019.08.048","article-title":"Near-infrared spectroscopy in pediatric congenital heart disease","volume":"34","author":"Zaleski","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"R7-20240901","doi-asserted-by":"crossref","first-page":"R104","DOI":"10.1186\/cc7940","article-title":"Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: A case-control study","volume":"13","author":"Liu","year":"2009","journal-title":"Crit Care"},{"key":"R8-20240901","first-page":"1","article-title":"Kidney disease: Improving global outcomes (KDIGO) acute kidney injury working group KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kellum","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"R9-20240901","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fped.2018.00097","article-title":"Changes in near-infrared spectroscopy after congenital cyanotic heart surgery","volume":"6","author":"Wong","year":"2018","journal-title":"Front Pediatr"},{"key":"R10-20240901","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1399-6576.2009.02037.x","article-title":"Low-dose vasopressin increases glomerular filtration rate, but impairs renal oxygenation in post-cardiac surgery patients","volume":"53","author":"Bragadottir","year":"2009","journal-title":"Acta Anesthesiol Scand"},{"key":"R11-20240901","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1540-8191.2002.01002.x","article-title":"Vasopressin therapy for vasoplegic syndrome following cardiopulmonary bypass","volume":"17","author":"Masetti","year":"2002","journal-title":"J Card Surg"},{"key":"R12-20240901","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/PCC.0b013e318172d7c8","article-title":"Vasopressin in pediatric shock and cardiac arrest","volume":"9","author":"Choong","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"R13-20240901","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1139\/h04-031","article-title":"Principles, techniques, and limitations of near infrared spectroscopy","volume":"29","author":"Ferrari","year":"2004","journal-title":"Can J Appl Physiol"},{"key":"R14-20240901","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13054-015-0760-9","article-title":"Intraoperative renal near-infrared spectroscopy indicates developing acute kidney injury in infants undergoing cardiac surgery with cardiopulmonary bypass: A case control study","volume":"19","author":"Ruf","year":"2015","journal-title":"Crit Care"},{"key":"R15-20240901","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00246-010-9839-x","article-title":"Low renal oximetry correlates with acute kidney injury after infant cardiac surgery","volume":"32","author":"Owens","year":"2011","journal-title":"Pediatr Cardiol"},{"key":"R16-20240901","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jtcvs.2005.10.003","article-title":"Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion","volume":"131","author":"Dent","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R17-20240901","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.athoracsur.2008.08.070","article-title":"Cerebral oxygen desaturation predicts cognitive decline and longer hospital stay after cardiac surgery","volume":"87","author":"Slater","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"R18-20240901","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1510\/icvts.2011.269647","article-title":"Plasma neutrophil gelatinase-associated lipocalin measured in consecutive patients after congenital heart surgery using point of care technology","volume":"13","author":"Koch","year":"2011","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"R19-20240901","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00467-015-3088-4","article-title":"TRIBE-AKI Consortium: Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery","volume":"30","author":"Greenberg","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"R20-20240901","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1681\/ASN.2015030261","article-title":"Acute dialysis quality initiative consensus XIII work group: Inflammation in AKI: Current understanding, key questions, and knowledge gaps","volume":"27","author":"Rabb","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"R21-20240901","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1681\/ASN.2012060633","article-title":"Messengers without borders: Mediators of systemic inflammatory response in AKI","volume":"24","author":"Ratliff","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"R22-20240901","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1034\/j.1399-6576.2001.045004407.x","article-title":"Cardiopulmonary bypass elicits a pro- and anti-inflammatory cytokine response and impaired neutrophil chemotaxis in neonatal pigs","volume":"45","author":"Brix-Christensen","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"R23-20240901","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/2193-1801-3-207","article-title":"Association of inflammatory and endothelial cell activation biomarkers with acute kidney injury after sepsis","volume":"3","author":"Powell","year":"2014","journal-title":"Springerplus"},{"key":"R24-20240901","first-page":"639","article-title":"Fluid balance and conventional and novel biomarkers of acute kidney injury in cardiovascular surgery","volume":"54","author":"Kambhampati","year":"2013","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"R25-20240901","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3109\/0886022X.2016.1165070","article-title":"Urinary markers of acute kidney injury in newborns with perinatal asphyxia","volume":"38","author":"Oncel","year":"2016","journal-title":"Ren Fail"},{"key":"R26-20240901","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s001340101014","article-title":"The effects of vasopressin on hemodynamics and renal function in severe septic shock: A case series","volume":"27","author":"Holmes","year":"2001","journal-title":"Intensive Care Med"},{"key":"R27-20240901","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0003-4975(99)01197-2","article-title":"Arginine vasopressin in the treatment of fifty patients with postcardiotomy vasodilatory shock","volume":"69","author":"Morales","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"R28-20240901","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/ki.2009.270","article-title":"A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery","volume":"76","author":"Zappitelli","year":"2009","journal-title":"Kidney Int"},{"key":"R29-20240901","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-0032-1322540","article-title":"Acute kidney injury in children undergoing surgery for congenital heart disease","volume":"22","author":"Pedersen","year":"2012","journal-title":"Eur J Pediatr Surg"},{"key":"R30-20240901","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jtcvs.2011.06.021","article-title":"Congenital heart surgery in infants: Effects of acute kidney injury on outcomes","volume":"143","author":"Blinder","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R31-20240901","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.athoracsur.2012.06.050","article-title":"Acute kidney injury after surgery for congenital heart disease","volume":"94","author":"Aydin","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"R32-20240901","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00134-003-2114-3","article-title":"Terlipressin for catecholamine-resistant septic shock in children","volume":"30","author":"Rodr\u00edguez-N\u00fa\u00f1ez","year":"2004","journal-title":"Intensive Care Med"},{"key":"R33-20240901","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.burns.2006.08.012","article-title":"Vasopressin for the septic burn patient","volume":"33","author":"Cartotto","year":"2007","journal-title":"Burns"},{"key":"R34-20240901","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1097\/01.CCM.0000059722.94182.79","article-title":"Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine resistant vasodilatory shock: Incidence and risk factors","volume":"31","author":"D\u00fcnser","year":"2003","journal-title":"Crit Care Med"}],"container-title":["Annals of Cardiac Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.aca_182_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:12:07Z","timestamp":1787760727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aca.aca_182_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/aca.aca_182_22","relation":{},"ISSN":["0971-9784","0974-5181"],"issn-type":[{"value":"0971-9784","type":"print"},{"value":"0974-5181","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-11-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}