{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:51Z","timestamp":1787841411858,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>To study the effects of dexmedetomidine (DEX) on perioperative blood glucose levels in adult diabetes mellitus (DM) patients undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Material:<\/jats:title>\n                    <jats:p>A prospective, observational study was conducted on 100 adult diabetic patients aged between 18 and 75 years undergoing cardiac surgery with cardiopulmonary bypass (CPB). The patients were divided into two groups (group D and group C) of 50 each. Group D patients received DEX infusion, whereas the group C patients received 0.9% normal saline infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The blood glucose levels, heart rate, mean arterial pressure, and serum potassium levels at different time points were comparable between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). The mean dose of insulin required in the combined population as well as in both controlled and uncontrolled DM patients was significantly less in group D than in group C (combined population - 36.03 \u00b1 22.71 vs 47.82 \u00b1 30.19 IU,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0297; uncontrolled DM - 37.36 \u00b1 23.9 IU vs 48.16 \u00b1 25.15 IU,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0301; controlled DM - 34.7 \u00b1 21.5 IU vs 47.63 \u00b1 35.25 IU,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0291). Duration of mechanical ventilation and VIS were comparable between the two groups. The incidence of arrhythmias (20% vs 46%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0059) and delirium (6% vs 20%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0384) was significantly less in group D than in group C. None of the patients in either group had stroke, myocardial ischemia, and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results suggested that DEX infusion during the intraoperative period was very effective for perioperative glycemic control and reduction of insulin requirement in DM patients undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_209_23","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T11:04:01Z","timestamp":1720091041000},"page":"228-234","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dexmedetomidine on Perioperative Glycemic Control in Adult Diabetic Patients Undergoing Cardiac Surgery"],"prefix":"10.4103","volume":"27","author":[{"given":"Nagarjuna","family":"Panidapu","sequence":"first","affiliation":[{"name":"Department of Cardiac Anesthesia, Amrita Institute of Medical Sciences, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravana","family":"Babu","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas V.","family":"Gadhinglajkar","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeez Mahammad","family":"Aspari","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barsha","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, Amrita Institute of Medical Sciences, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"R1-20240901","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12872-023-03279-8","article-title":"7-year outcomes in diabetic patients after coronary artery bypass graft in a developing 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