{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:06:18Z","timestamp":1788257178169,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Cardioplegia is essential for adequate myocardial protection. There continues to remain ambiguity regarding the ideal cardioplegia for adequate myocardial protection in congenital heart surgery. This study compares clinical outcomes using St Thomas II solution and Del Nido cardioplegia in neonates undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      All neonates (&lt;30 days) from 2011 to 2017 who underwent surgery requiring cardioplegic arrest were analyzed retrospectively. We divided the cohort into two groups depending on cardioplegia received, as group A (Blood cardioplegia with St Thomas II solution,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 56) and group B (Del Nido cardioplegia,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 48). Various demographic, intraoperative, early postoperative, and discharge variables were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two groups were similar in age, gender, pre-operative diagnosis, and risk category. Cardiopulmonary bypass (CPB) time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), aortic cross-clamp (ACC) time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018), and the number of doses of cardioplegia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) were significantly lower with Del Nido group. Though vasoactive inotropic score (VIS) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036) was high during the first 24 h in the immediate postoperative period in group A, there was no difference in early mortality among both groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.749). Both groups did not show significant differences related to various postoperative and discharge variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>When compared to St. Thomas solution, the use of Del Nido cardioplegia solution in neonates is associated with a significant decrease in CPB and ACC times and VIS in the first 24 h after surgery. The choice of cardioplegia (St Thomas\/Del Nido) in neonates does not affect early mortality and early postoperative clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_220_20","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T13:32:18Z","timestamp":1642771938000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Outcomes of Del Nido Cardioplegia and St Thomas Blood Cardioplegia in Neonatal congenital Heart Surgery"],"prefix":"10.4103","volume":"25","author":[{"given":"Sameer","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarinath","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas V.","family":"Gadhinglajkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip D.","family":"Baruah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya V.","family":"Ramanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Arun","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P R","family":"Suneel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiju S.","family":"Dharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-8-20240901","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0140-6736(55)93381-X","article-title":"Elective cardiac arrest","volume":"269","author":"Melrose","year":"1955","journal-title":"Lancet"},{"key":"R3-8-20240901","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0022-5223(19)35328-0","article-title":"Comparison of single dose versus multiple dose crystalloid cardioplegia in neonate. 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