{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:04:03Z","timestamp":1789409043226,"version":"build-2803163510"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postoperative major bleeding is a relatively common complication of patients undergoing corrective surgery of tetralogy of Fallot (TOF). Life-threatening blood losses can lead to aggressive transfusions or reoperation. Little is known about the risk factors associated with a bleeding tendency in TOF patients. This study aimed to establish predictive models for postoperative blood loss and mortality in TOF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study involving patients with TOF who were posted for corrective cardiac surgery in a single hospital between 2010 and 2015. Hospital records including sociodemographic, pre- and intra-operative characteristics were extracted. Postoperative blood loss (within 24 and 48 h) and 30-day mortality were the primary and secondary outcomes, respectively. Multivariate linear and logistic regression models were used to identify determinants of outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 60 patients were included in this study. The median age was 1 year (interquartile range = 0.62\u20135) and the male to female ratio of 1.7:1. Mean postoperative blood loss within 24 h was 283 \u00b1 212 mL. In multivariate linear regression, preoperative hematocrit (\u03b2 = 6.63,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042) and duration of intraoperative oxygenator with CPB (\u03b2 = 5.16,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025) were significantly correlated with postoperative blood loss within 24 h. After adjusting for sociodemographic, intra- and post-operative characteristics, preoperative hematocrit (odds ratio [OR] = 1.10, 95% confidence interval [CI] = 1.01\u20131.21), and postoperative red blood cell transfusions (OR = 3.88, 95% CI = 1.16\u201312.9) showed statistically significant association with 30-day mortality. The area under the receiver operating characteristic curve of the multivariable model was 0.863.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Preoperative levels of erythrocytosis appear to predict postoperative blood loss and short-term mortality in TOF patients undergoing corrective surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_25_17","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T11:15:08Z","timestamp":1491477308000},"page":"188-192","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The Utility of Preoperative Level of Erythrocytosis in the Prediction of Postoperative Blood Loss and 30-day Mortality in Patients with Tetralogy of Fallot"],"prefix":"10.4103","volume":"20","author":[{"given":"Jhon Harold","family":"Guevara","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Hospital Universitario del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Zorrilla-Vaca","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hospital Universitario del Valle, Cali, Colombia"},{"name":"Faculty of Health, School of Medicine, Universidad del Valle, Hospital Universitario del Valle, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria C","family":"Silva-Gordillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Centro Medico Imbanaco, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250528","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s00268-009-0296-8","article-title":"Tetralogy of Fallot: Yesterday and today","volume":"34","author":"Starr","year":"2010","journal-title":"World J Surg"},{"key":"R2-20250528","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ccl.2015.07.002","article-title":"Tetralogy of Fallot: General principles of management","volume":"33","author":"Downing","year":"2015","journal-title":"Cardiol Clin"},{"key":"R3-20250528","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0735-1097(97)00318-5","article-title":"Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair","volume":"30","author":"Nollert","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"R4-20250528","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1117-1936.163357","article-title":"Profile and outcome of congenital heart diseases in children: A preliminary experience from a tertiary center in sokoto, North Western Nigeria","volume":"22","author":"Sani","year":"2015","journal-title":"Niger Postgrad Med J"},{"key":"R5-20250528","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/pan.12705","article-title":"Cyanotic congenital heart disease (CCHD): Focus on hypoxemia, secondary erythrocytosis, and coagulation alterations","volume":"25","author":"Zabala","year":"2015","journal-title":"Paediatr Anaesth"},{"key":"R6-20250528","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jclinane.2005.08.012","article-title":"Severe polycythemia in an infant with uncorrected tetralogy of Fallot presenting for noncardiac surgery","volume":"18","author":"Hunyady","year":"2006","journal-title":"J Clin Anesth"},{"key":"R7-20250528","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/01.CIR.32.1.65","article-title":"Relationship between polycythemia and surgical mortality in patients undergoing total correction for tetralogy of Fallot","volume":"32","author":"Leachman","year":"1965","journal-title":"Circulation"},{"key":"R8-20250528","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00000658-198309000-00002","article-title":"Surgical results and protocols in the spectrum of tetralogy of Fallot","volume":"198","author":"Kirklin","year":"1983","journal-title":"Ann Surg"},{"key":"R9-20250528","first-page":"89","article-title":"Long-term survival after repair of tetralogy of Fallot","volume":"32","author":"Pokorski","year":"2000","journal-title":"J Insur Med"},{"key":"R10-20250528","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0022-5223(19)38815-4","article-title":"Surgical repair of tetralogy of Fallot. Long-term follow-up with particular emphasis on late death and reoperation","volume":"89","author":"Zhao","year":"1985","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R11-20250528","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0735-1097(02)01718-7","article-title":"Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia","volume":"39","author":"Horigome","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"R12-20250528","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.ijcard.2012.06.019","article-title":"Fibrinogen function is impaired in whole blood from patients with cyanotic congenital heart disease","volume":"167","author":"Jensen","year":"2013","journal-title":"Int J Cardiol"}],"container-title":["Annals of Cardiac Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00660469-201720020-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:08:27Z","timestamp":1787774907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00660469-201720020-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/aca.aca_25_17","relation":{},"ISSN":["0971-9784","0974-5181"],"issn-type":[{"value":"0971-9784","type":"print"},{"value":"0974-5181","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}