{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:32:23Z","timestamp":1787776343562,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Poor sleep quality is emerging as high prevalence among the patients suffering from cardiometabolic disturbances. The vascular polypeptide endothelin 1 (ET-1) is involved in many of the health disorders. However, its potential involvement in patients having poor sleep quality along with cardiovascular problem is limited. The present study was formulated to conduct a prospective analysis of the relationship between ET-1 and in hospital outcome in sleep disorder patients undergoing routine coronary artery bypass grafting (CABG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 156 patients were enrolled and divided into two groups based on the Pittsburg Sleep Quality Index (PSQI) of \u22645 (Group I,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 101) or &gt;5 (Group II,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 55). Blood sample was collected before anesthesia induction (ET-1a) and at 48 h (ET-1b) to analyze the plasma ET-1 and blood sugar level. The patients were monitored for any intraoperative adverse events and postoperative complications during their hospital stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both groups were comparable in relation to age, sex, incidence of smoking and alcohol consumption. The distribution of comorbid conditions was also similar in both groups. The ET-1 level was higher in Group II than Group I before anesthesia induction as well as 48 h postoperatively (4.5 \u00b1 1.75 vs. 10.61 \u00b1 9.3,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001; 2.08 \u00b1 1.3 vs. 8.3 \u00b1 9.86,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001, respectively). The Group II patients had a longer duration of mechanical ventilation (14.6 \u00b1 12.05 vs. 10.1 \u00b1 8.19,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), Intensive Care Unit stay (2.08 \u00b1 0.95 vs. 2.7 \u00b1 1.45,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0016) and hospital stay (5.98 \u00b1 1.73 vs. 7.8 \u00b1 3.66,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001, respectively). The high number of patients from Group II required inotrope and intra-aortic balloon pump support while compared with Group I (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.05 in each). The overall postoperative complication rate was significantly higher among patients with PSQI of &gt;5 (Group II) except the rate of infection and neurological complications which was similar among both group of patients. The postoperative in hospital mortality was nil in Group I and 3.6% in Group II (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.05). There was a strong relationship between PSQI and ET-1 at both the time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Poor sleep quality associated with a higher incidence of adverse perioperative events in patients undergoing elective CABG. There exists a potential link between poor sleep quality and ET-1 in these groups of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aca.aca_30_17","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T11:15:08Z","timestamp":1491477308000},"page":"193-199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Does Sleep Quality Affects the Immediate Clinical Outcome in Patients Undergoing Coronary Artery Bypass Grafting: A Clinico-biochemical Correlation"],"prefix":"10.4103","volume":"20","author":[{"given":"Minati","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushree","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind P","family":"Hote","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam Malhotra","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MV","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250528","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1532-5415.2000.tb03901.x","article-title":"Daytime sleepiness predicts mortality and cardiovascular disease in older adults. 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