{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:46:36Z","timestamp":1791985596357,"version":"4.4.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Loeys\u2013Dietz syndrome (LDS) is a rare autosomal dominant connective tissue disorder characterized by aggressive aortopathy, craniofacial anomalies and systemic involvement. Rapid aortic root dilatation and valvular dysfunction mandate an early surgical intervention. We report a case of 15-year-old boy with LDS, rapidly progressive aortic root dilatation and severe aortic regurgitation (AR) who underwent successful Bentall procedure. The case highlights the need of early detection, multidisciplinary involvement and meticulous anesthetic care.<\/jats:p>","DOI":"10.4103\/aca.aca_317_25","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:00:23Z","timestamp":1791824423000},"page":"622-626","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bentall Procedure in a Patient with Loeys\u2013Dietz Syndrome: A Case Report"],"prefix":"10.4103","volume":"29","author":[{"given":"Dheeraj","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Amrita Institute of Medical Sciences and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Amrita Institute of Medical Sciences and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Madavathazathil","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Amrita Institute of Medical Sciences and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bhate","sequence":"additional","affiliation":[{"name":"Department of CTVS, Amrita Institute of Medical Sciences and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"R1-20261014","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-\u03b2 receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N Engl J 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Bentall procedure for giant ascending aortic aneurysm in Loeys-Dietz syndrome","volume":"16","author":"Sicim","year":"2023","journal-title":"Ann Pediatr Cardiol"},{"key":"R6-20261014","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/humu.23407","article-title":"A mutation update on the LDS-associated genes TGFB2\/3 and SMAD2\/3","volume":"39","author":"Schepers","year":"2018","journal-title":"Hum Mutat"},{"key":"R7-20261014","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.athoracsur.2011.04.003","article-title":"Valve-sparing aortic root replacement in Loeys-Dietz syndrome","volume":"92","author":"Patel","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"R8-20261014","first-page":"304","article-title":"The Bentall procedure: A systematic review and meta-analysis","volume":"9","author":"Harky","year":"2020","journal-title":"Ann Cardiothorac 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