{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:50:27Z","timestamp":1785765027292,"version":"3.56.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Context:<\/jats:title>\n Inflammatory and oxidative stress responses are markedly amplified following cardiopulmonary bypass (CPB), contributing to myocardial injury, vascular dysregulation, and potential multiorgan dysfunction.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n This study aimed to define how inflammatory, oxidative, and cellular stress responses quantified by tumor necrosis factor-alpha (TNF-\n \u03b1<\/jats:italic>\n ), hydroxyl (OH\n -<\/jats:sup>\n ) radical scavenging capacity, and heat shock protein-70 (HSP-70) relate to early postoperative myocardial contractility, arterial tone, and vasoactive\u2013inotropic requirements after CPB.\n <\/jats:p>\n <\/jats:sec>\n \n Settings and Design:<\/jats:title>\n A prospective cohort study was conducted in patients undergoing coronary artery bypass grafting (CABG) with preserved preoperative ejection fraction (EF).<\/jats:p>\n <\/jats:sec>\n \n Methods and Materials:<\/jats:title>\n \n Postoperative biomarker levels and perioperative changes in TNF-\n \u03b1<\/jats:italic>\n , OH\n -<\/jats:sup>\n scavenging capacity, and HSP-70 with early myocardial contractility maximum rate of rise of left ventricular pressure (dP\/dt\n max<\/jats:sub>\n ), arterial elastance, and vasoactive\u2013inotropic score were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n Correlation analyses were performed using Pearson\u2019s or Spearman\u2019s correlation coefficients as appropriate.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 52 patients were included in the study. Higher postoperative HSP-70 levels were associated with reduced early myocardial contractility (\n r<\/jats:italic>\n = \u22120.315;\n P<\/jats:italic>\n = 0.025) and increased vasoactive\u2013inotropic requirements (\n \u03c1<\/jats:italic>\n =0.341;\n P<\/jats:italic>\n = 0.014). No significant associations were observed among postoperative biomarker variables, and changes in TNF-\n \u03b1<\/jats:italic>\n or OH\n -<\/jats:sup>\n scavenging capacity were not related to early postoperative hemodynamic outcomes (all\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Early post-CPB myocardial dysfunction appears more closely associated with cellular stress (HSP-70) than with inflammatory or oxidative responses. Elevated HSP-70 levels in the early postoperative CABG may act as damage-associated molecular patterns associated with transient myocardial depression and higher vasoactive\u2013inotropic requirements, whereas early inflammatory and oxidative changes showed no direct hemodynamic correlation.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aca.aca_34_26","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:00:32Z","timestamp":1783969232000},"page":"359-366","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Another Marker of Inflammation and Oxidative Stress and Its Impact on Myocardial Function, Arterial Elastance, and Vasoactive\u2013Inotropic Score After Coronary Revascularization Surgery: A Prospective Cohort Study"],"prefix":"10.4103","volume":"29","author":[{"given":"Teuku A.","family":"Husain","sequence":"first","affiliation":[{"name":"Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"},{"name":"Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanes N. E.","family":"Putranto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"},{"name":"Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philia","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"},{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Rehatta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia"},{"name":"Department of 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