{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:20Z","timestamp":1786653560697,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postoperative thrombocytopenia is a frequent complication in cardiac surgery, associated with increased morbidity and mortality. Our study aimed to describe platelet count after cardiac surgery and identify predictors of postoperative thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective, single-center study including 519 adult patients who underwent cardiac surgery without operative platelet transfusion. The primary outcome was the incidence of postoperative thrombocytopenia, defined using three thresholds: &lt;150 G\/L, &lt;100 G\/L, and &lt;50 G\/L. Platelet counts were recorded daily from preoperative day to postoperative day 7. Independent predictors were identified using multivariate logistic regression for a threshold of 100 G\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thrombocytopenia &lt; 150 G\/L occurred in 306 patients (59%), &lt;100 G\/L in 92 (18%), and &lt; 50 G\/L in 35 (7%). The incidence of thrombocytopenia depended on the type of surgery (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Mitral valve surgery, ascending aorta procedures, and the use of sutureless aortic valve prostheses were associated with increased thrombocytopenia rates. Platelet counts were higher in patients who have had off-pump coronary surgery within the first five days (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Five independent predictors were identified: older age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.022), lower baseline platelet count (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), higher creatinine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04), operative transfused units of red blood cells (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.015), and higher autotransfusion volume (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). The model using only preoperative variables achieved an AUC of 0.83. Finally, thrombocytopenia &lt;100 G\/L was associated with more blood loss (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), more postoperative transfusions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), and longer intensive care unit stay (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study differentiates pre- and perioperative risk factors for thrombocytopenia in cardiac surgery to define a targeted, individualized platelet management strategy.<\/jats:p>\n                  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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Jouan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Limoges Teaching Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vandroux","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Limoges Teaching Hospital, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"R1-20260803","first-page":"339","article-title":"Platelet counts, acute kidney injury, and mortality after coronary artery bypass grafting surgery","volume":"124","author":"Kertai","year":"2016","journal-title":"Ain-Shams J Anesthesiol"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.athoracsur.2019.10.039","article-title":"Thrombocytopenia after cardiopulmonary bypass is 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