{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:51:00Z","timestamp":1786719060445,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anesth Essays Res"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/aer.aer_106_18","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T02:40:47Z","timestamp":1555900847000},"page":"132","source":"Crossref","is-referenced-by-count":7,"title":["Hepatic protective effect of dexmedetomidine after partial hepatectomy surgery: A prospective controlled study"],"prefix":"10.4103","volume":"13","author":[{"given":"HaniI","family":"Taman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Elhefnawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0259-1162.253110-1","first-page":"860","volume-title":"Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases","author":"Kooby","year":"2003","journal-title":"Ann Surg"},{"key":"key-10.4103\/0259-1162.253110-2","first-page":"423","volume-title":"European survey on the application of vascular clamping in liver surgery","author":"van","year":"2007","journal-title":"Dig Surg"},{"key":"key-10.4103\/0259-1162.253110-3","first-page":"969","volume-title":"Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions","author":"Dahmani","year":"2005","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0259-1162.253110-4","first-page":"70","volume-title":"Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: A histopathologic study","author":"Kocoglu","year":"2009","journal-title":"Ren Fail"},{"key":"key-10.4103\/0259-1162.253110-5","first-page":"524","volume-title":"The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats","author":"Engelhard","year":"2003","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0259-1162.253110-6","first-page":"538","volume-title":"The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts","author":"Okada","year":"2007","journal-title":"Resuscitation"},{"key":"key-10.4103\/0259-1162.253110-7","first-page":"687","volume-title":"Dexmedetomidine use in general anaesthesia","author":"Arcangeli","year":"2009","journal-title":"Curr Drug Targets"},{"key":"key-10.4103\/0259-1162.253110-8","first-page":"1055","volume-title":"Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: A randomized controlled trial","author":"Wang","year":"2014","journal-title":"Br J Anaesth"},{"key":"key-10.4103\/0259-1162.253110-9","first-page":"40","volume-title":"Clinical application, the use of dexmedetomidine in intensive care sedation","author":"Yahya","year":"2010","journal-title":"Crit Care Shock"},{"key":"key-10.4103\/0259-1162.253110-10","first-page":"96","volume-title":"The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats","author":"T\u00fcfek","year":"2013","journal-title":"Int J Surg"},{"key":"key-10.4103\/0259-1162.253110-11","first-page":"385","volume-title":"The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats","author":"Sahin","year":"2013","journal-title":"J Surg Res"},{"key":"key-10.4103\/0259-1162.253110-12","first-page":"46","volume-title":"Dexmedetomidine prevents alterations of intestinal microcirculation that are induced by surgical stress and pain in a novel rat model","author":"Yeh","year":"2012","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0259-1162.253110-13","first-page":"734","volume-title":"The systemic inflammatory response syndrome in acute liver failure","author":"Rolando","year":"2000","journal-title":"Hepatology"},{"key":"key-10.4103\/0259-1162.253110-14","first-page":"1312","volume-title":"Effect of perioperative systemic \u03b12 agonists on postoperative morphine consumption and pain intensity: Systematic review and meta-analysis of randomized controlled trials","author":"Blaudszun","year":"2012","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0259-1162.253110-15","first-page":"646","volume-title":"Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements","author":"Gurbet","year":"2006","journal-title":"Can J Anaesth"},{"key":"key-10.4103\/0259-1162.253110-16","first-page":"1036","volume-title":"Acomparison of liver function after hepatectomy with inflow occlusion between sevoflurane and propofol anesthesia","author":"Song","year":"2010","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0259-1162.253110-17","first-page":"112","volume-title":"Acute liver failure following hepatic resection: Incidence, presentation, prevention and management in ICU","author":"Chris","year":"2013","journal-title":"Intensive Care Soc"},{"key":"key-10.4103\/0259-1162.253110-18","first-page":"513","volume-title":"Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery","author":"Jensen","year":"1992","journal-title":"Br J Surg"},{"key":"key-10.4103\/0259-1162.253110-19","first-page":"145","volume-title":"Liver failure after major hepatic resection","author":"Garcea","year":"2009","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"key-10.4103\/0259-1162.253110-20","first-page":"1188","volume-title":"Prediction, prevention and management of postresection liver failure","author":"Hammond","year":"2011","journal-title":"Br J Surg"},{"key":"key-10.4103\/0259-1162.253110-21","first-page":"292","volume-title":"Hepatic steatosis as a potential risk factor for major hepatic resection","author":"Behrns","year":"1998","journal-title":"J Gastrointest Surg"},{"key":"key-10.4103\/0259-1162.253110-22","first-page":"243","volume-title":"Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases","author":"Karoui","year":"2006","journal-title":"Ann Surg"},{"key":"key-10.4103\/0259-1162.253110-23","first-page":"705","volume-title":"Case scenario: Postoperative liver failure after liver resection in a cirrhotic patient","author":"Paugam-Burtz","year":"2012","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0259-1162.253110-24","first-page":"247","volume-title":"The effect of hepatic vascular inflow occlusion on liver tissue pH, carbon dioxide, and oxygen partial pressures: Defining the optimal clamp\/release regime for intermittent portal clamping","author":"Brooks","year":"2007","journal-title":"J Surg Res"},{"key":"key-10.4103\/0259-1162.253110-25","first-page":"578","volume-title":"Operative mortality, blood loss and the use of Pringle manoeuvres in 526 consecutive liver resections","author":"Lordan","year":"2009","journal-title":"Ann R Coll Surg Engl"},{"key":"key-10.4103\/0259-1162.253110-26","first-page":"1062","volume-title":"Effects of intermittent Pringle's manoeuvre on cirrhotic compared with normal liver","author":"Sugiyama","year":"2010","journal-title":"Br J Surg"},{"key":"key-10.4103\/0259-1162.253110-27","first-page":"267","volume-title":"A 2 adrenoceptor agonist \u2013 Dexmedetomidine role in anaesthesia and intensive care: A clinical review","author":"Murthy","year":"2009","journal-title":"J Anaesthesiol Clin Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0970-9185","issn-type":"print"},{"key":"key-10.4103\/0259-1162.253110-28","first-page":"710","volume-title":"Dexmedetomidine provides cortical neuroprotection: Impact on anaesthetic-induced neuroapoptosis in the rat developing brain","author":"Sanders","year":"2010","journal-title":"Acta Anaesthesiol Scand"},{"key":"key-10.4103\/0259-1162.253110-29","first-page":"1322","volume-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","author":"Taniguchi","year":"2004","journal-title":"Crit Care Med"},{"key":"key-10.4103\/0259-1162.253110-30","first-page":"1272","volume-title":"Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice","author":"Gu","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"key-10.4103\/0259-1162.253110-31","first-page":"105","volume-title":"Effect of dexmedetomidine on testicular torsion\/detorsion damage in rats","author":"Hanci","year":"2010","journal-title":"Urol Int"},{"key":"key-10.4103\/0259-1162.253110-32","first-page":"44","volume-title":"Free radicals and antioxidants in normal physiological functions and human disease","author":"Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"key-10.4103\/0259-1162.253110-33","first-page":"1068","volume-title":"Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury","author":"Can","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"key-10.4103\/0259-1162.253110-34","first-page":"151","volume-title":"Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury","author":"Yang","year":"2008","journal-title":"Acta Anaesthesiol Taiwan"},{"key":"key-10.4103\/0259-1162.253110-35","first-page":"1204","volume-title":"Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats","author":"Yang","year":"2009","journal-title":"Resuscitation"},{"key":"key-10.4103\/0259-1162.253110-36","first-page":"e273","volume-title":"Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats","author":"Yang","year":"2011","journal-title":"J Surg Res"},{"key":"key-10.4103\/0259-1162.253110-37","first-page":"550","volume-title":"Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients","author":"Memi\u015f","year":"2007","journal-title":"Br J Anaesth"},{"key":"key-10.4103\/0259-1162.253110-38","first-page":"1035","volume-title":"Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats","author":"Zhang","year":"2012","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0259-1162.253110-39","first-page":"382","volume-title":"The effects of increasing plasma concentrations of dexmedetomidine in humans","author":"Ebert","year":"2000","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0259-1162.253110-40","first-page":"235","volume-title":"Clonidine and the sympatico-adrenal response to coronary artery by-pass surgery","author":"Helbo-Hansen","year":"1986","journal-title":"Acta Anaesthesiol Scand"},{"key":"key-10.4103\/0259-1162.253110-41","first-page":"317","volume-title":"Effect of dexmedetomidine on the release of [3H]-noradrenaline from rat kidney cortex slices: Characterization of alpha2-adrenoceptor","author":"Taoda","year":"2001","journal-title":"Neurochem Int"},{"key":"key-10.4103\/0259-1162.253110-42","first-page":"209","volume-title":"The dose-related effects of dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: A randomized, triple-blind, placebo-controlled study","author":"Balkanay","year":"2015","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"key-10.4103\/0259-1162.253110-43","first-page":"648","volume-title":"Acomparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation","author":"Dere","year":"2010","journal-title":"Eur J Anaesthesiol"},{"key":"key-10.4103\/0259-1162.253110-44","first-page":"1","volume-title":"Dexmedetomidine for neurological surgery","author":"Bekker","year":"2005","journal-title":"Neurosurgery"},{"key":"key-10.4103\/0259-1162.253110-45","first-page":"9","volume-title":"Renal effects of dexmedetomidine during coronary artery bypass surgery: A randomized placebo-controlled study","author":"Leino","year":"2011","journal-title":"BMC Anesthesiol"}],"container-title":["Anesthesia: Essays and Researches"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:43:20Z","timestamp":1786715000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.AER_106_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"alternative-id":["253110"],"URL":"https:\/\/doi.org\/10.4103\/aer.aer_106_18","relation":{},"ISSN":["0259-1162"],"issn-type":[{"value":"0259-1162","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}