{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:07Z","timestamp":1787757667520,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postoperative pain relief after total knee arthroplasty (TKA) can be attained by using several techniques such as intravenous analgesia, epidural analgesia, and peripheral nerve blocks that include femoral nerve and saphenous nerve. Several authors recommended intra-articular injection of local anesthetic (IALA) as a part of multimodal analgesia regimens for TKA instead of other techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The present study compares IALA technique efficacy with single-shot femoral nerve block (FNB) as part of multimodal analgesia regimen in TKA patients for postoperative pain management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and Design:<\/jats:title>\n                    <jats:p>Perioperative care, randomized double-blind comparative study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>We recruited a total of 60 patients scheduled for unilateral total knee replacement under spinal anesthesia. Subjects were allocated randomly into two groups FNB and IALA receiving ultrasound-guided FNB and Intra-articular local anesthesia and morphine mix infiltration, respectively. Twenty-four hour postoperative morphine consumption through patient-controlled analgesia was the primary outcome measure in our study. Secondary outcome measures were pain scores, nausea and vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>Chi-square test, Mann\u2013Whitney test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The amount of morphine consumed at the end of 24 h was noted to be higher in IALA group as compared to FNB (FNB \u2212 16.03 \u00b1 9.37 mgs; IALA \u2212 23.60 \u00b1 13.73 mgs\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). Visual analog score at 24 h with knee flexion was better in FNB group (FNB \u2212 1.27 \u00b1 1.43; IALA 2.42 \u00b1 2.54,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>FNB technique provides better analgesia in comparison to IALA for postoperative pain management in terms of PCA morphine consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aer.aer_112_21","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T13:09:26Z","timestamp":1639660166000},"page":"208-212","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Intra-Articular Local Anesthesia Infiltration versus Femoral Nerve Block for Postoperative Pain Management in Total Knee Arthroplasty"],"prefix":"10.4103","volume":"15","author":[{"given":"Mahesh M","family":"Chandrashekaraiah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal H","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi V","family":"Sahitya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin C","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan J","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Adeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20240901","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/17453674.2011.636682","article-title":"Why still in hospital after fast-track hip and knee arthroplasty?","volume":"82","author":"Husted","year":"2011","journal-title":"Acta Orthop"},{"key":"R2-10-20240901","first-page":"139","article-title":"The effect of single-injection femoral nerve block on rehabilitation and length of hospital stay after total knee replacement","volume":"27","author":"Wang","year":"2002","journal-title":"Reg Anesth Pain 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Retrospective trial with the first and last 100 patients?","volume":"15","author":"Najfeld","year":"2020","journal-title":"J Orthop Surg Res"},{"key":"R15-10-20240901","first-page":"104","article-title":"Multimodal analgesia protocol for pain management after total knee arthroplasty: Comparison of three different regional analgesic techniques","volume":"21","author":"Karpetas","year":"2021","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"R16-10-20240901","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/17453674.2011.581264","article-title":"Pain control after total knee arthroplasty: A randomized trial comparing local infiltration anesthesia and continuous femoral block","volume":"82","author":"Affas","year":"2011","journal-title":"Acta Orthop"},{"key":"R17-10-20240901","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.12659\/MSM.899320","article-title":"Comparison of 2 analgesia modalities in total knee replacement surgery: Is there an effect on knee function rehabilitation?","volume":"23","author":"Zinkus","year":"2017","journal-title":"Med Sci Monit"},{"key":"R18-10-20240901","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/bja\/aeu155","article-title":"Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: A systematic review","volume":"113","author":"Andersen","year":"2014","journal-title":"Br J Anaesth"}],"container-title":["Anesthesia Essays &amp; Researches"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_112_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:49:04Z","timestamp":1787755744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_112_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/aer.aer_112_21","relation":{},"ISSN":["0259-1162"],"issn-type":[{"value":"0259-1162","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}