{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:35:42Z","timestamp":1786739742230,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Women undergoing hysterectomy present a unique set of challenges to the anesthesiologist in terms of postoperative pain management. This study was conducted to see the effect of single-dose perioperative duloxetine 60 mg on postoperative analgesia following abdominal hysterectomy under spinal anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective randomized placebo-controlled study was conducted on 64 patients scheduled to undergo elective abdominal hysterectomy under spinal anesthesia. The patients were divided into two groups of 32 in each, Group D received duloxetine 60 mg 2 h preoperatively and Group P received placebo 2 h preoperatively. Postoperatively, the patients were evaluated by an independent observer for pain on rest and during cough at 0 (arrival at postanesthesia care unit), 2, 4, 6, 12, and 24 h. In addition, the postoperative analgesic requirements and adverse effects were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      Independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test\/Mann\u2013Whitney U-test was used to compare the pain score between two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The demographic data were comparable between both the groups. The mean Visual Analogue Scale scores assessed postoperatively at rest and during cough which were not statistically significant between the two groups. The rescue analgesic consumption in Group D (0.97 \u00b1 0.86) and Group P (1.25 \u00b1 0.76) was comparable and statistically not significant. The total analgesic requirement between duloxetine (4.94 \u00b1 0.84) and placebo (1.25 \u00b1 0.76) group was comparable and statistically not significant. The incidence of nausea vomiting and somnolence was higher in Group D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We conclude that patients receiving a single dose of 60 mg duloxetine as premedication before hysterectomy under spinal anesthesia are no better than placebo on postoperative pain during the first 24 h.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aer.aer_47_21","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T15:16:53Z","timestamp":1630336613000},"page":"107-110","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Single Preoperative Dose of Duloxetine on Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy under Spinal Anesthesia"],"prefix":"10.4103","volume":"15","author":[{"given":"Sharmila","family":"Rajamohan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath Abloodu","family":"Chikkapillappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapti","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak Seenappa","family":"Pujari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejesh C.","family":"Anandaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha C.","family":"Rajappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20240901","first-page":"57","article-title":"Effect of perioperative duloxetine on postoperative pain relief following anterior cervical microdiscectomy and fusion. A pilot study","volume":"2","author":"Saoud","year":"2013","journal-title":"World Spinal Column J"},{"key":"R2-18-20240901","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.ajp.0000135236.12705.2d","article-title":"The roles of pain catastrophizing and anxiety in the prediction of postoperative pain intensity: A prospective study","volume":"21","author":"Granot","year":"2005","journal-title":"Clin J Pain"},{"key":"R3-18-20240901","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1213\/00000539-199810000-00014","article-title":"Factors affecting discharge time in adult outpatients","volume":"87","author":"Pavlin","year":"1998","journal-title":"Anesth Analg"},{"key":"R4-18-20240901","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/bja\/aet127","article-title":"Sex differences in pain: A brief review of clinical and experimental findings","volume":"111","author":"Bartley","year":"2013","journal-title":"Br J Anaesth"},{"key":"R5-18-20240901","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/bja\/aer094","article-title":"Effect of patient sex on general anaesthesia and recovery","volume":"106","author":"Buchanan","year":"2011","journal-title":"Br J Anaesth"},{"key":"R6-18-20240901","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1399-6576.2004.00484.x","article-title":"'Protective premedication': An option with gabapentin and related drugs.A review of gabapentin and pregabalin in in the treatment of post-operative pain?","volume":"48","author":"Dahl","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"R7-18-20240901","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.anclin.2011.04.001","article-title":"New concepts in acute pain management: Strategies to prevent chronic postsurgical pain, opioid-induced hyperalgesia, and outcome measures","volume":"29","author":"Grosu","year":"2011","journal-title":"Anesthesiol Clin"},{"key":"R8-18-20240901","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/bja\/aeq158","article-title":"Duloxetine reduces morphine requirements after knee replacement surgery","volume":"105","author":"Ho","year":"2010","journal-title":"Br J Anaesth"},{"key":"R9-18-20240901","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1213\/ANE.0000000000000971","article-title":"Perioperative duloxetine to improve postoperative recovery after abdominal hysterectomy: A prospective, randomized, double-blinded, placebo-controlled study","volume":"122","author":"Castro-Alves","year":"2016","journal-title":"Anesth Analg"},{"key":"R10-18-20240901","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/ALN.0000000000001228","article-title":"Duloxetine and subacute pain after knee arthroplasty when added to a multimodal analgesic regimen: A randomized, placebo-controlled, triple-blinded trial","volume":"125","author":"YaDeau","year":"2016","journal-title":"Anesthesiology"},{"key":"R11-18-20240901","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/1687-7934.133345","article-title":"Efficacy of perioperative duloxetine on acute and chronic postmastectomy pain","volume":"7","author":"Nasr","year":"2014","journal-title":"Ain-Shams J Anaesthesiol"},{"key":"R12-18-20240901","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3344\/kjp.2020.33.1.40","article-title":"Perioperative duloxetine as part of a multimodal analgesia regime reduces postoperative pain in lumbar canal stenosis surgery: A randomized, triple blind, and placebo-controlled trial","volume":"33","author":"Govil","year":"2020","journal-title":"Korean J Pain"},{"key":"R13-18-20240901","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/sja.SJA_519_17","article-title":"Impact of duloxetine and dexamethasone for improving postoperative pain after laparoscopic gynecological surgeries: A randomized clinical trial","volume":"12","author":"Kassim","year":"2018","journal-title":"Saudi J Anaesth"}],"container-title":["Anesthesia Essays &amp; Researches"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_47_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:32:12Z","timestamp":1786735932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_47_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/aer.aer_47_21","relation":{},"ISSN":["0259-1162"],"issn-type":[{"value":"0259-1162","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}