{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:33:22Z","timestamp":1787758402696,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Multiple methods have been proposed to prevent the incidence of hypotension in women undergoing cesarean section under spinal anesthesia. This study was conducted to compare the efficacy of phenylephrine (50 \u03bcg.min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) versus ondansetron (8 mg) in the prevention of such complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      We included a total of 184 full-term pregnant women who were randomly divided into two groups: Group P included 92 cases who were commenced on phenylephrine infusion (50 \u03bcg.min\n                      <jats:sup>\u22121<\/jats:sup>\n                      given after puncture) and Group O included the other 92 cases who were administered ondansetron (8 mg given 5 min before puncture).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Demographic data were not significantly different between the two groups. Maternal hypotension was significantly more encountered in the ondansetron group (51.6% vs. 22%) and ephedrine was used more significantly in that group (19.8% vs. 8.8%). In addition, nausea and skin flushing were more commonly encountered in the same group. The incidence of vomiting and patient discomfort was not significantly different between the two study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Phenylephrine is markedly superior to ondansetron in the prevention of maternal hypotension and vasopressor need during cesarean section under spinal anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aer.aer_48_22","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T05:43:20Z","timestamp":1663566200000},"page":"226-230","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Prophylactic Phenylephrine Infusion Versus Intravenous Ondansetron on Hypotension During Spinal Anesthesia for Cesarean Section"],"prefix":"10.4103","volume":"16","author":[{"given":"Hani Gharib","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa Abd","family":"ELatief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240901","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/anae.14841","article-title":"Prevention of hypotension after spinal anaesthesia for caesarean section: A systematic review and network meta-analysis of randomised controlled trials","volume":"75","author":"Fitzgerald","year":"2020","journal-title":"Anaesthesia"},{"key":"R2-9-20240901","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4103\/sja.SJA_237_17","article-title":"Reducing by 50% the incidence of maternal hypotension during elective caesarean delivery under spinal anesthesia: Effect of prophylactic ondansetron and\/or continuous infusion of phenylephrine \u2013 A double-blind, randomized, placebo controlled trial","volume":"11","author":"Ortiz-G\u00f3mez","year":"2017","journal-title":"Saudi J Anaesth"},{"key":"R3-9-20240901","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/ACO.0b013e32834588c5","article-title":"Maternal haemodynamic changes during spinal anaesthesia for caesarean section","volume":"24","author":"Langes\u00e6ter","year":"2011","journal-title":"Curr Opin Anaesthesiol"},{"key":"R4-9-20240901","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1399-6576.2011.02646.x","article-title":"Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis","volume":"56","author":"Veeser","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"key":"R5-9-20240901","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijoa.2014.01.005","article-title":"The effect of intravenous ondansetron on maternal haemodynamics during elective caesarean delivery under spinal anaesthesia: A double-blind, randomised, placebo-controlled trial","volume":"23","author":"Ortiz-G\u00f3mez","year":"2014","journal-title":"Int J Obstet Anesth"},{"key":"R6-9-20240901","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/anae.14080","article-title":"International consensus statement on the management of hypotension with vasopressors during caesarean section under spinal anaesthesia","volume":"73","author":"Kinsella","year":"2018","journal-title":"Anaesthesia"},{"key":"R8-9-20240901","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/bja\/aeu267","article-title":"Preventing Spinal Hypotension during Caesarean Delivery: What is the Latest?","volume":"114","author":"Butwick","year":"2015","journal-title":"British J Anaesth"},{"key":"R9-9-20240901","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1213\/ANE.0b013e3181e1db21","article-title":"A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery","volume":"111","author":"Allen","year":"2010","journal-title":"Anesth Analg"},{"key":"R10-9-20240901","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1213\/ANE.0b013e3181f2eae1","article-title":"The dose-dependent effects of phenylephrine for elective cesarean delivery under spinal anesthesia","volume":"111","author":"Stewart","year":"2010","journal-title":"Anesth Analg"},{"key":"R11-9-20240901","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/bja\/73.4.471","article-title":"Spinal anaesthesia for caesarean section: Comparison of infusions of phenylephrine and ephedrine","volume":"73","author":"Hall","year":"1994","journal-title":"Br J Anaesth"},{"key":"R12-9-20240901","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/anae.12445","article-title":"Prophylactic phenylephrine for caesarean section under spinal anaesthesia: Systematic review and meta-analysis","volume":"69","author":"Heesen","year":"2014","journal-title":"Anaesthesia"},{"key":"R13-9-20240901","first-page":"332","article-title":"Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: A double-blind, placebo-controlled study","volume":"33","author":"Owczuk","year":"2008","journal-title":"Reg Anesth Pain Med"},{"key":"R14-9-20240901","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijoa.2011.08.002","article-title":"Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: A double-blind randomised, placebo-controlled study","volume":"21","author":"Sahoo","year":"2012","journal-title":"Int J Obstet Anesth"},{"key":"R15-9-20240901","first-page":"158061","article-title":"Effect of Ondansetron on the occurrence of hypotension and on neonatal parameters during spinal anesthesia for elective caesarean section: A prospective, randomized, controlled, double-blind study","volume":"2015","author":"Trabelsi","year":"2015","journal-title":"Anesthesiol Res Pract"},{"key":"R16-9-20240901","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/roaic.roaic_19_18","article-title":"Effect of prophylactic ondansetron versus ephedrine on postspinal hemodynamics in percutaneous nephrolithotomy","volume":"5","author":"Nada","year":"2018","journal-title":"Res Opin Anesth Intensive Care"}],"container-title":["Anesthesia Essays &amp; Researches"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_48_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:13:59Z","timestamp":1787757239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_48_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/aer.aer_48_22","relation":{},"ISSN":["0259-1162"],"issn-type":[{"value":"0259-1162","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}