{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:36:07Z","timestamp":1786739767431,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We describe the anesthetic management of a spontaneous vaginal delivery at 38 weeks' gestation in a 36-year-old patient with Gitelman syndrome (GS). GS is a rare autosomal recessive renal tubulopathy characterized by hypomagnesemia, hypocalciuria, and secondary aldosteronism, which results in hypokalemia and metabolic alkalosis. To minimize any increase in catecholamine levels and consequent risk of ventricular arrhythmias, a labor epidural analgesia was administered using ropivacaine and fentanyl, along with intravenous magnesium and potassium supplementation. Ropivacaine was substituted for routine bupivacaine to decrease the risk of drug-induced cardiotoxicity. In the event of a cesarean section, the anesthetic plan was to continue with top-up epidural anesthesia and in case of failure, to convert to general anesthesia using propofol and rocuronium for induction. Delivery outcome was successful and uneventful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aer.aer_82_21","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T15:16:53Z","timestamp":1630336613000},"page":"146-148","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Peripartum Management of Gitelman Syndrome for Vaginal Delivery"],"prefix":"10.4103","volume":"15","author":[{"given":"Georgia","family":"Micha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Kalopita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridoula","family":"Theodorou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stroumpoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-25-20240901","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1750-1172-3-22","article-title":"Gitelman syndrome","volume":"3","author":"Knoers","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"R2-25-20240901","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jclinane.2011.04.009","article-title":"Perioperative considerations in patients with Gitelman syndrome: A case series","volume":"24","author":"Farmer","year":"2012","journal-title":"J Clin Anesth"},{"key":"R3-25-20240901","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.21037\/apm-19-299","article-title":"Outcome of twin pregnancy in a patient with Gitelman syndrome: A case report and literature review","volume":"9","author":"Yu","year":"2020","journal-title":"Ann Palliat Med"},{"key":"R4-25-20240901","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijoa.2010.05.004","article-title":"Anaesthesia for caesarean section in a patient with Gitelman's syndrome","volume":"19","author":"Shanbhag","year":"2010","journal-title":"Int J Obstet Anesth"},{"key":"R5-25-20240901","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4103\/ija.IJA_40_20","article-title":"Anaesthesia for emergency caesarean section in a patient with Gitelman syndrome","volume":"64","author":"Venugopalan","year":"2020","journal-title":"Indian J Anaesth"},{"key":"R6-25-20240901","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4103\/0970-9185.173359","article-title":"Anesthesia in a patient with gitelman syndrome","volume":"32","author":"Shah","year":"2016","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"R8-25-20240901","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/AOG.0b013e3182075317","article-title":"Pregnancy in inherited hypokalemic salt-losing renal tubular disorder","volume":"117","author":"Mascetti","year":"2011","journal-title":"Obstet Gynecol"},{"key":"R9-25-20240901","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/ccr3.1122","article-title":"Gitelman syndrome: A rare life-threatening case of hypokalemic paralysis mimicking Guillain-Barr\u00e9 syndrome during pregnancy and review of the literature","volume":"5","author":"Elkoundi","year":"2017","journal-title":"Clin Case Rep"},{"key":"R10-25-20240901","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1471-0528.2004.00148.x","article-title":"Is normalisation of serum potassium and magnesium always necessary in Gitelman Syndrome for a successful obstetric outcome?","volume":"111","author":"Basu","year":"2004","journal-title":"BJOG"},{"key":"R11-25-20240901","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijgo.2008.05.007","article-title":"Gitelman syndrome in pregnancy","volume":"103","author":"de Haan","year":"2008","journal-title":"Int J Gynaecol Obstet"},{"key":"R12-25-20240901","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4330\/wjc.v5.i4.87","article-title":"Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management","volume":"5","author":"Fazio","year":"2013","journal-title":"World J Cardiol"},{"key":"R14-25-20240901","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0300060520942619","article-title":"The anesthetic bupivacaine induces cardiotoxicity by targeting L-type voltage-dependent calcium channels","volume":"48","author":"Gao","year":"2020","journal-title":"J Int Med Res"}],"container-title":["Anesthesia Essays &amp; Researches"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_82_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:32:47Z","timestamp":1786735967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aer.aer_82_21"}},"subtitle":["A Case Report and Review of Literature"],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/aer.aer_82_21","relation":{},"ISSN":["0259-1162"],"issn-type":[{"value":"0259-1162","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}