{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:18:27Z","timestamp":1793837907778,"version":"4.6.1"},"reference-count":124,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/ http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>With advancing age and lifespan throughout the globe in both developed and developing nations, the risk for developing cognitive loss and mood disorders increases significantly to the extent that after reaching the age of 65, this risk almost doubles every 5 years thereafter. As a result, a corresponding rise in non-communicable diseases will impact individuals with dementia and mood disorders involving Alzheimer\u2019s disease, multiple sclerosis, depression, and anxiety. On a clinical basis, multiple risk factors and presentations that involve the loss of intellectual capacity with the onset of mental health conditions, mood disorders preceding dementia, sleep fragmentation initiation, perivascular pathway disruptions, and circadian clock dysfunction can occur in both cognitive loss and mood disorders, but a much broader scope of shared underlying cellular pathways form the underpinning for the connection of these disorders that rests upon metabolic disorders, such as diabetes mellitus. Cognitive impairment and mood disorders can precede one another as well as coexist with related co-morbidities that involve metabolic disorders with diabetes mellitus, but present treatment strategies for these disorders are primarily symptomatic in nature and rely upon disease-altering therapies that may slow disease progression but also may be accompanied by disabling complications. Given these challenges, the institution of innovative avenues is critical at this juncture to address the mutual cellular mechanisms for the treatment of disorders involving Alzheimer\u2019s disease, multiple sclerosis, depression, and anxiety. The pathways of cell senescence and telomere biology with aging, cellular metabolic dysfunction, apolipoprotein E, oxidative stress, programmed cell death with autophagy, ferroptosis, and pyroptosis, mechanistic target of rapamycin, glucagon-like peptide-1 receptor agonism, mammalian forkhead transcription factors of the \u201cO\u201d class, and mitochondrial dynamics offer a compelling potential to bridge these underlying pathways into unifying strategies for transition into efficacious clinical care for dementia and mood disorders. Tempered with this enthusiasm for these mutual disease mechanisms is the complexity of these pathways that will require meticulous oversight of the interdependence among pathway components and their ultimate biological impact on clinical outcomes.<\/jats:p>","DOI":"10.4103\/agingadv.agingadv-d-26-00011","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:00:59Z","timestamp":1781780459000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways"],"prefix":"10.4103","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5049-9116","authenticated-orcid":false,"given":"Kenneth","family":"Maiese","sequence":"first","affiliation":[{"name":"Cellular and Molecular Signaling, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"3","key":"R2-20260706","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1007\/s12035-024-04462-4","article-title":"Unlocking hope: Therapeutic advances and approaches in modulating the Wnt pathway for neurodegenerative diseases","volume":"62","author":"Faraji","year":"2025","journal-title":"Mol Neurobiol"},{"issue":"19","key":"R3-20260706","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms26199739","article-title":"Neurofilament biomarkers in neurology: From neuroinflammation to neurodegeneration, bridging established and novel analytical advances with clinical practice","volume":"26","author":"Daponte","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"R4-20260706","doi-asserted-by":"crossref","first-page":"27293","DOI":"10.1038\/s41598-025-12426-4","article-title":"Vanadyl sulfate restores memory impairment in streptozotocin-induced rat model of sporadic alzheimer\u2019s disease by repressing FoxO1 gene expression","volume":"15","author":"Ebrahimifar","year":"2025","journal-title":"Sci Rep"},{"issue":"204","key":"R5-20260706","doi-asserted-by":"crossref","first-page":"310","DOI":"10.24976\/Discov.Med.202638204.25","article-title":"Cannabis and cannabidiol, GLP\u20131 receptors, and autophagy: the burgeoning link between cognitive neurodegeneration with Alzheimer\u2019s disease and metabolic disorders","volume":"38","author":"Maiese","year":"2026","journal-title":"Discov Med"},{"key":"R6-20260706","doi-asserted-by":"crossref","first-page":"128301","DOI":"10.1016\/j.talanta.2025.128301","article-title":"Detection of erythropoietin in blood plasma through an SPRi-based biosensor","volume":"295","author":"Chirco","year":"2025","journal-title":"Talanta"},{"issue":"7","key":"R7-20260706","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/bioengineering10070871","article-title":"Cognitive impairment in multiple sclerosis","volume":"10","author":"Maiese","year":"2023","journal-title":"Bioengineering (Basel)"},{"issue":"2","key":"R8-20260706","doi-asserted-by":"crossref","first-page":"e2560205","DOI":"10.1001\/jamanetworkopen.2025.60205","article-title":"Anxiety, depression, and care barriers in adults with intellectual and developmental disabilities","volume":"9","author":"Osuna","year":"2026","journal-title":"JAMA Netw Open"},{"key":"R9-20260706","doi-asserted-by":"crossref","first-page":"1642605","DOI":"10.3389\/fpsyt.2025.1642605","article-title":"Glymphatic system and psychiatric disorders: need for a new paradigm?","volume":"16","author":"Barlattani","year":"2025","journal-title":"Front Psychiatry"},{"issue":"12","key":"R10-20260706","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s00213-025-06834-7","article-title":"Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K\/Akt\/mTOR pathway","volume":"242","author":"Magdy","year":"2025","journal-title":"Psychopharmacology"},{"key":"R11-20260706","doi-asserted-by":"crossref","first-page":"1273570","DOI":"10.3389\/fimmu.2023.1273570","article-title":"The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk","volume":"14","author":"Maiese","year":"2023","journal-title":"Front Immunol"},{"issue":"3","key":"R12-20260706","first-page":"241","article-title":"Chronopharmacology-Driven Precision Therapies for Time-Optimized Cardiometabolic Disease Management","volume":"15","author":"Satyam","year":"2026","journal-title":"Biology (Basel)"},{"key":"R13-20260706","doi-asserted-by":"crossref","first-page":"1696419","DOI":"10.3389\/fendo.2025.1696419","article-title":"Recent advances in incretin-based therapy for the treatment of cognitive impairment associated to the type 2 diabetes mellitus: preclinical and clinical studies - a narrative review","volume":"16","author":"Giofr\u00e8","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"R14-20260706","doi-asserted-by":"crossref","first-page":"14","DOI":"10.58832\/ctr.2025.10.9.2","article-title":"Molecular and cellular drivers of inflammaging: Uncovering the diverse mechanisms and interventions of inflammaging","volume":"2","author":"Van de Walle","year":"2025","journal-title":"Clin Transl Rep"},{"issue":"4","key":"R16-20260706","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/1878-0261.70163","article-title":"Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology","volume":"20","author":"Ilie","year":"2026","journal-title":"Mol Oncol"},{"issue":"1","key":"R17-20260706","doi-asserted-by":"crossref","first-page":"e01534","DOI":"10.1002\/cbdv.202501534","article-title":"Molecular roadmap of COVID-19: From viral entry to therapeutic targets","volume":"23","author":"Ishola","year":"2026","journal-title":"Chem Biodivers"},{"issue":"3","key":"R18-20260706","first-page":"383","article-title":"Circle(s) of life: The circadian clock from birth to death","volume":"12","author":"Olejniczak","year":"2023","journal-title":"Biology (Basel)"},{"key":"R19-20260706","first-page":"690","article-title":"Innovative therapeutic strategies for cardiovascular disease","volume":"22","author":"Maiese","year":"2023","journal-title":"EXCLI J"},{"issue":"1","key":"R20-20260706","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/medicina62010143","article-title":"GLP-1 receptor agonist exenatide protects against doxorubicin-induced cardiotoxicity through the SIRT1 pathway: An electrocardiographic, 99mTc-PYP scintigraphic, and biochemical study","volume":"62","author":"Salmanoglu","year":"2026","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"R21-20260706","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/mgr.MEDGASRES-D-24-00059","article-title":"Biological gases, oxidative stress, artificial intelligence, and machine learning for neurodegeneration and metabolic disorders","volume":"15","author":"Maiese","year":"2025","journal-title":"Med Gas Res"},{"issue":"1","key":"R22-20260706","doi-asserted-by":"crossref","first-page":"98948","DOI":"10.4239\/wjd.v16.i1.98948","article-title":"Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging","volume":"16","author":"Maiese","year":"2025","journal-title":"World J Diabetes"},{"key":"R23-20260706","doi-asserted-by":"crossref","first-page":"112160","DOI":"10.1016\/j.mad.2026.112160","article-title":"Mechanistic insights into stem cell aging: Pathways and processes","volume":"230","author":"Fauzi","year":"2026","journal-title":"Mech Ageing Dev"},{"key":"R24-20260706","doi-asserted-by":"crossref","first-page":"1627921","DOI":"10.3389\/fnagi.2025.1627921","article-title":"Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases","volume":"17","author":"Jaganathan","year":"2025","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"R25-20260706","doi-asserted-by":"crossref","first-page":"100906","DOI":"10.1016\/j.jgr.2025.10.003","article-title":"Ginsenoside Rb1-enhanced decellularized extracellular matrix hydrogels ameliorates mitochondrial dysfunction and cellular aging in sepsis-induced acute lung injury","volume":"50","author":"Gao","year":"2026","journal-title":"J Ginseng Res"},{"issue":"1","key":"R27-20260706","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/med.70013","article-title":"Exploring autophagy inducing molecules: targeting diverse pathways in alzheimer\u2019s disease management","volume":"46","author":"Singh","year":"2026","journal-title":"Med Res Rev"},{"issue":"11","key":"R28-20260706","doi-asserted-by":"crossref","first-page":"e71457","DOI":"10.1002\/hsr2.71457","article-title":"Investigating the associated factors of mood disorders and fatigue in multiple sclerosis patients with cognitive impairment: A cross-sectional study","volume":"8","author":"Sedighi","year":"2025","journal-title":"Health Sci Rep"},{"issue":"1","key":"R29-20260706","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/jnp.12285","article-title":"Word finding, prosody and social cognition in multiple sclerosis","volume":"17","author":"Yap","year":"2023","journal-title":"J Neuropsychol"},{"issue":"3","key":"R30-20260706","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s00415-012-6705-1","article-title":"Cognitive impairment, health-related quality of life and vocational status at early stages of multiple sclerosis: a 7-year longitudinal study","volume":"260","author":"Ruet","year":"2013","journal-title":"J Neurol"},{"issue":"11","key":"R31-20260706","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.3390\/diagnostics12112571","article-title":"Serum and CSF biomarkers predict active early cognitive decline rather than established cognitive impairment at the moment of RRMS diagnosis","volume":"12","author":"Tiu","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"R32-20260706","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s40478-022-01444-2","article-title":"Tau seeding in cases of multiple sclerosis","volume":"10","author":"LaCroix","year":"2022","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"R33-20260706","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/glia.24322","article-title":"Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes","volume":"71","author":"Torii","year":"2023","journal-title":"Glia"},{"issue":"1","key":"R34-20260706","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1038\/s41598-023-32974-x","article-title":"The associations of socioeconomic status with incident dementia and Alzheimer\u2019s disease are modified by leucocyte telomere length: a population-based cohort study","volume":"13","author":"Lai","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"R35-20260706","doi-asserted-by":"crossref","first-page":"e0282363","DOI":"10.1371\/journal.pone.0282363","article-title":"Telomere length and brain imaging phenotypes in UK Biobank","volume":"18","author":"Topiwala","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"R36-20260706","doi-asserted-by":"crossref","first-page":"e000050","DOI":"10.1212\/WN9.0000000000000050","article-title":"Neuroanatomical correlates of depressive symptoms in early multiple sclerosis","volume":"2","author":"Dos Santos Silva","year":"2026","journal-title":"Neurol Open Access"},{"issue":"2","key":"R37-20260706","doi-asserted-by":"crossref","first-page":"366","DOI":"10.62641\/aep.v53i2.1838","article-title":"Exercise-induced activation of SIRT1\/BDNF\/mTORC1 signaling pathway: A novel mechanism to reduce neuroinflammation and improve post-stroke depression","volume":"53","author":"Tang","year":"2025","journal-title":"Actas Esp Psiquiatr"},{"issue":"2","key":"R38-20260706","doi-asserted-by":"crossref","first-page":"e12667","DOI":"10.1111\/jpi.12667","article-title":"Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation","volume":"69","author":"Ali","year":"2020","journal-title":"J Pineal Res"},{"issue":"9","key":"R39-20260706","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.7150\/thno.95197","article-title":"Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice","volume":"14","author":"Yan","year":"2024","journal-title":"Theranostics"},{"issue":"1","key":"R40-20260706","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"R41-20260706","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/biom13050816","article-title":"Cellular metabolism: A fundamental component of degeneration in the nervous system","volume":"13","author":"Maiese","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"R42-20260706","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00406-025-01978-1","article-title":"Objectifying persistent subjective cognitive impairment following COVID-19 infection: cross-sectional data from an outpatient memory-clinic in Germany","volume":"276","author":"Tarantini","year":"2026","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"11","key":"R43-20260706","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4330\/wjc.v16.i11.632","article-title":"Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways","volume":"16","author":"Maiese","year":"2024","journal-title":"World J Cardiol"},{"key":"R44-20260706","doi-asserted-by":"crossref","first-page":"101459","DOI":"10.1016\/j.mam.2026.101459","article-title":"Impact of type 2 diabetes on malignancies of the female reproductive system","volume":"108","author":"Espinoza","year":"2026","journal-title":"Mol Aspects Med"},{"key":"R45-20260706","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00238-025-02384-5","article-title":"Targeting oxidative stress in diabetic wound repair: combined photobiomodulation and adipose-derived stem cell therapy","volume":"49","author":"Moheghi","year":"2026","journal-title":"Eur J Plast Surg"},{"issue":"2","key":"R46-20260706","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1210\/clinem\/dgac580","article-title":"Diabetes mellitus is associated with higher serum neurofilament light chain levels in the general US population","volume":"108","author":"Ciardullo","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"R47-20260706","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ajo.2026.02.014","article-title":"The association between diabetic retinopathy severity and dementia risk: A TriNetX longitudinal cohort study","volume":"285","author":"Khangura","year":"2026","journal-title":"Am J Ophthalmol"},{"key":"R48-20260706","doi-asserted-by":"crossref","first-page":"120092","DOI":"10.1016\/j.jep.2025.120092","article-title":"Interlinking diabetes and Alzheimer\u2019s disease: A pathway through medicinal plant-based treatments","volume":"351","author":"Pattanaik","year":"2025","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"R49-20260706","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3390\/cells10051236","article-title":"Insulin resistance and diabetes mellitus in Alzheimer\u2019s disease","volume":"10","author":"Burillo","year":"2021","journal-title":"Cells"},{"key":"R50-20260706","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2147\/IJGM.S524138","article-title":"The dual role and therapeutic implications of the Wnt\/beta-Catenin pathway in diabetic kidney disease","volume":"18","author":"Adeerjiang","year":"2025","journal-title":"Int J Gen Med"},{"issue":"1","key":"R51-20260706","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s42003-025-09112-6","article-title":"Cell- and sex-specificity in the transcriptomic response of the hippocampal neurovascular unit to obesity","volume":"8","author":"Norman","year":"2025","journal-title":"Commun Biol"},{"issue":"1","key":"R52-20260706","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/clinchem\/hvad196","article-title":"Looking to the future of early detection in cancer: Liquid biopsies, imaging, and artificial intelligence","volume":"70","author":"Foser","year":"2024","journal-title":"Clin Chem"},{"issue":"2","key":"R53-20260706","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neulet.2012.10.045","article-title":"Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes","volume":"531","author":"Aksu","year":"2012","journal-title":"Neurosci Lett"},{"issue":"2","key":"R54-20260706","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/02698811241295379","article-title":"Repurposing of erythropoietin as a neuroprotective agent against methotrexate-induced neurotoxicity in rats","volume":"39","author":"Sabry","year":"2025","journal-title":"J Psychopharmacol"},{"issue":"2","key":"R55-20260706","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1248\/bpb.b25-00596","article-title":"Intracellular signaling pathways for erythropoietin-induced cell proliferation in primary cultured hepatocytes","volume":"49","author":"Moteki","year":"2026","journal-title":"Biol Pharm Bull"},{"issue":"5","key":"R56-20260706","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/bcp.12845","article-title":"New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs","volume":"82","author":"Ign\u00e1cio","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"R57-20260706","doi-asserted-by":"crossref","first-page":"102760","DOI":"10.1016\/j.redox.2023.102760","article-title":"Energy stress modulation of AMPK\/FoxO3 signaling inhibits mitochondria-associated ferroptosis","volume":"63","author":"Zhong","year":"2023","journal-title":"Redox Biol"},{"key":"R58-20260706","doi-asserted-by":"crossref","first-page":"6619515","DOI":"10.1155\/2021\/6619515","article-title":"Role of BDNF-mTORC1 signaling pathway in female depression","volume":"2021","author":"An","year":"2021","journal-title":"Neural Plast"},{"issue":"6","key":"R59-20260706","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/ijnp\/pyy017","article-title":"Repeated systemic treatment with rapamycin affects behavior and amygdala protein expression in rats","volume":"21","author":"Hadamitzky","year":"2018","journal-title":"Int J Neuropsychopharmacol"},{"key":"R60-20260706","doi-asserted-by":"crossref","first-page":"104011","DOI":"10.1016\/j.msard.2022.104011","article-title":"The association of apolipoprotein E (ApoE) genotype and cognitive outcomes in multiple sclerosis; a systematic review and meta-analysis","volume":"65","author":"Naseri","year":"2022","journal-title":"Mult Scler Relat Disord"},{"issue":"8","key":"R61-20260706","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/dneu.22710","article-title":"Models and treatments for traumatic optic neuropathy and demyelinating optic neuritis","volume":"79","author":"Bastakis","year":"2019","journal-title":"Dev Neurobiol"},{"issue":"7","key":"R62-20260706","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/genes13071188","article-title":"Association of APOE serum levels and APOE epsilon2, epsilon3, and epsilon4 alleles with optic neuritis","volume":"13","author":"Momkute","year":"2022","journal-title":"Genes (Basel)"},{"issue":"1","key":"R63-20260706","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13195-024-01569-7","article-title":"Association of education attainment, smoking status, and alcohol use disorder with dementia risk in older adults: a longitudinal observational study","volume":"16","author":"Tang","year":"2024","journal-title":"Alzheimers Res Ther"},{"issue":"10","key":"R64-20260706","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/eye.2016.94","article-title":"Revisiting the role of erythropoietin for treatment of ocular disorders","volume":"30","author":"Shirley Ding","year":"2016","journal-title":"Eye (Lond)"},{"issue":"9","key":"R65-20260706","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1111\/ene.15912","article-title":"Association of multiple-sclerosis-related mortality with COVID-19 and other common infections: a multiple causes of death analysis","volume":"30","author":"Fedeli","year":"2023","journal-title":"Eur J Neurol"},{"key":"R66-20260706","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-026-03514-6","article-title":"Nitric oxide-mediated S-nitrosylation of TSC2 drives mTOR dysregulation across Shank3 and Cntnap2 models of autism spectrum disorder","author":"Ojha","year":"2026","journal-title":"Mol Psychiatry"},{"issue":"22","key":"R67-20260706","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.3390\/cells12222595","article-title":"Cornerstone cellular pathways for metabolic disorders and diabetes mellitus: Non-coding RNAs, Wnt signaling, and AMPK","volume":"12","author":"Maiese","year":"2023","journal-title":"Cells"},{"issue":"1","key":"R68-20260706","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/biophysica6010012","article-title":"Autophagy\u2013proteasome crosstalk in neurodegenerative diseases: Cellular proteostasis, neural interactions, and therapeutic implications","volume":"6","author":"Passi","year":"2026","journal-title":"Biophysica"},{"issue":"3","key":"R69-20260706","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2337\/db10-1194","article-title":"Rictor\/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size","volume":"60","author":"Gu","year":"2011","journal-title":"Diabetes"},{"key":"R70-20260706","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1038\/ncomms5934","article-title":"Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes","volume":"5","author":"Lim","year":"2014","journal-title":"Nat Commun"},{"key":"R71-20260706","first-page":"a27905251","article-title":"Diabetes, protein misfolding, and heat stress: molecular insights and translational perspectives","volume":"10","author":"Abreu","year":"2026","journal-title":"TH Open"},{"issue":"11","key":"R72-20260706","doi-asserted-by":"crossref","first-page":"e13889","DOI":"10.1111\/and.13889","article-title":"Impact of diabetic hyperglycaemia and insulin therapy on autophagy and impairment in rat epididymis","volume":"52","author":"Li","year":"2020","journal-title":"Andrologia"},{"key":"R73-20260706","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ydbio.2024.02.008","article-title":"Circadian clock genes REV-ERBalpha regulates the secretion of IL-1beta in deciduous tooth pulp stem cells by regulating autophagy in the process of physiological root resorption of deciduous teeth","volume":"510","author":"Di","year":"2024","journal-title":"Dev Biol"},{"key":"R74-20260706","doi-asserted-by":"crossref","first-page":"644121","DOI":"10.3389\/fmed.2021.644121","article-title":"Protective or harmful: The dual roles of autophagy in diabetic retinopathy","volume":"8","author":"Gong","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"8","key":"R75-20260706","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1080\/15548627.2017.1327927","article-title":"MTOR controls genesis and autophagy of GABAergic interneurons during brain development","volume":"13","author":"Ka","year":"2017","journal-title":"Autophagy"},{"issue":"12","key":"R76-20260706","doi-asserted-by":"crossref","first-page":"e3325","DOI":"10.1002\/brb3.3325","article-title":"Gandouling alleviates nerve injury through PI3K\/Akt\/FoxO1 and Sirt1\/FoxO1 signaling pathway to inhibit autophagy in the rats model of Wilson\u2019s disease","volume":"13","author":"Chen","year":"2023","journal-title":"Brain Behav"},{"issue":"2","key":"R77-20260706","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000444360","article-title":"The Akt\/mTOR\/p70S6K pathway is involved in the neuroprotective effect of erythropoietin on hypoxic\/ischemic brain injury in a neonatal rat model","volume":"110","author":"Lee","year":"2016","journal-title":"Neonatology"},{"issue":"1","key":"R78-20260706","doi-asserted-by":"crossref","first-page":"7890455","DOI":"10.1155\/jfbc\/7890455","article-title":"Ginsenoside Rf suppresses oxidative stress\u2013induced insomnia by modulating mitophagy through the AMPK\/mTOR signaling pathway","volume":"2025","author":"Li","year":"2025","journal-title":"J Food Biochem"},{"key":"R79-20260706","doi-asserted-by":"crossref","first-page":"103042","DOI":"10.1016\/j.arr.2026.103042","article-title":"Aging and neuropathic pain: Mitochondria-to-glia cascade, system mechanisms, and therapeutic strategies","volume":"116","author":"Majumdar","year":"2026","journal-title":"Ageing Res Rev"},{"issue":"10","key":"R80-20260706","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/00207454.2023.2210409","article-title":"The interplay between tauopathy and aging through interruption of UPR\/Nrf2\/autophagy crosstalk in the Alzheimer\u2019s disease transgenic experimental models","volume":"134","author":"Amini","year":"2024","journal-title":"Int J Neurosci"},{"issue":"6","key":"R81-20260706","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/jnc.15831","article-title":"Ferroptosis and central nervous system demyelinating diseases","volume":"165","author":"Qin","year":"2023","journal-title":"J Neurochem"},{"key":"R82-20260706","doi-asserted-by":"crossref","first-page":"7503553","DOI":"10.1155\/2022\/7503553","article-title":"Deficient autophagy in microglia aggravates repeated social defeat stress-induced social avoidance","volume":"2022","author":"Sakai","year":"2022","journal-title":"Neural Plast"},{"issue":"12","key":"R83-20260706","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1007\/s12035-018-1026-8","article-title":"11\u03b2-HSD1 inhibition by RL-118 promotes autophagy and correlates with reduced oxidative stress and inflammation, enhancing cognitive performance in SAMP8 mouse model","volume":"55","author":"Puigoriol-Illamola","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"5","key":"R84-20260706","doi-asserted-by":"crossref","first-page":"e36188","DOI":"10.1371\/journal.pone.0036188","article-title":"Palmitate activates autophagy in INS-1E beta-cells and in isolated rat and human pancreatic islets","volume":"7","author":"Martino","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"R85-20260706","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2174\/1570159X14666160321122900","article-title":"Autophagy in diabetic retinopathy","volume":"14","author":"Rosa","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"R86-20260706","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11064-025-04378-y","article-title":"The miR-34a-5p promotes hippocampal neuronal ferroptosis in epilepsy by regulating SIRT1","volume":"50","author":"Gao","year":"2025","journal-title":"Neurochem Res"},{"key":"R87-20260706","doi-asserted-by":"crossref","first-page":"103787","DOI":"10.1016\/j.redox.2025.103787","article-title":"Decoding Parkinson\u2019s disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations","volume":"85","author":"Liu","year":"2025","journal-title":"Redox Biol"},{"issue":"1","key":"R88-20260706","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13578-025-01418-6","article-title":"Programmed cell death in the cognitive impairment of obstructive sleep apnea","volume":"15","author":"Ou","year":"2025","journal-title":"Cell Biosci"},{"issue":"4","key":"R89-20260706","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s10735-025-10405-7","article-title":"Exendin-4 alleviates diabetic retinopathy by activating autophagy via regulation of the adenosine monophosphate-activated protein kinase\/sirtuin 1 pathway","volume":"56","author":"Liu","year":"2025","journal-title":"J Mol Histol"},{"issue":"1","key":"R90-20260706","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/brainsci15010053","article-title":"Spinal involvement of TRPV1 and PI3K\/AKT\/mTOR pathway during chronic postoperative pain in mice","volume":"15","author":"Santos","year":"2025","journal-title":"Brain Sci"},{"issue":"11-12","key":"R91-20260706","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s10528-012-9532-2","article-title":"Effects of selenium and exendin-4 on glucagon-like peptide-1 receptor, IRS\u20131, and Raf-1 in the liver of diabetic rats","volume":"50","author":"Barakat","year":"2012","journal-title":"Biochem Genet"},{"issue":"4","key":"R92-20260706","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000345529","article-title":"Epidermal growth factor receptor transactivation is necessary for glucagon-like peptide-1 to protect PC12 cells from apoptosis","volume":"97","author":"Kimura","year":"2013","journal-title":"Neuroendocrinology"},{"issue":"1","key":"R93-20260706","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/biom16010099","article-title":"Impaired brain incretin and gut hormone expression in human alcohol-related brain damage: Opportunities for therapeutic targeting","volume":"16","author":"de la Monte","year":"2026","journal-title":"Biomolecules"},{"issue":"1","key":"R94-20260706","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s13311-019-00805-5","article-title":"Vildagliptin attenuates Huntington\u2019s disease through activation of GLP-1 receptor\/PI3K\/Akt\/BDNF pathway in 3-nitropropionic acid rat model","volume":"17","author":"Sayed","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"2","key":"R95-20260706","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/1753-0407.12177","article-title":"Glucagon-like peptide-1 analog-mediated protection against cholesterol-induced apoptosis via mammalian target of rapamycin activation in pancreatic \u03b2TC\u20136 cells -1mTOR\u03b2TC\u20136","volume":"7","author":"Zhou","year":"2015","journal-title":"J Diabetes"},{"issue":"3","key":"R96-20260706","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/dom.70415","article-title":"Comparative safety of glucose-lowering medications on depression in adults with type 2 diabetes","volume":"28","author":"Hooker","year":"2026","journal-title":"Diabetes Obes Metab"},{"key":"R97-20260706","article-title":"Risk of new-onset hair loss with semaglutide and tirzepatide: A TriNetX cohort study","volume":"2026","author":"Herrera","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"R98-20260706","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10522-025-10380-2","article-title":"FOXO: a key target in regulating aging and age-related diseases","volume":"27","author":"Wang","year":"2026","journal-title":"Biogerontology"},{"key":"R99-20260706","doi-asserted-by":"crossref","first-page":"1424561","DOI":"10.3389\/fnmol.2024.1424561","article-title":"The role of Foxo3a in neuron-mediated cognitive impairment","volume":"17","author":"Liu","year":"2024","journal-title":"Front Mol Neurosci"},{"issue":"7","key":"R100-20260706","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.3390\/ijms27072989","article-title":"Conserved pathways, divergent outcomes: A cross-species genomic perspective on the cancer-neurodegeneration paradox","volume":"27","author":"Rajarathinam","year":"2026","journal-title":"Int J Mol Sci"},{"issue":"29","key":"R101-20260706","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1038\/sj.onc.1206778","article-title":"Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases","volume":"22","author":"Charvet","year":"2003","journal-title":"Oncogene"},{"issue":"4","key":"R102-20260706","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s12011-025-04828-2","article-title":"Disruption of the SIRT1\/PI3K\/AKT signaling axis mediates fluoride-induced cardiotoxicity: evidence from in vitro and zebrafish models","volume":"204","author":"Guo","year":"2026","journal-title":"Biol Trace Elem Res"},{"key":"R103-20260706","doi-asserted-by":"crossref","first-page":"583478","DOI":"10.3389\/fphys.2020.583478","article-title":"Exercise-induced autophagy suppresses sarcopenia through Akt\/mTOR and Akt\/FoxO3a signal pathways and AMPK-mediated mitochondrial quality control","volume":"11","author":"Zeng","year":"2020","journal-title":"Front Physiol"},{"key":"R104-20260706","doi-asserted-by":"crossref","first-page":"112662","DOI":"10.1016\/j.mce.2025.112662","article-title":"Advanced maternal age induced altered FoxO1 activation and cellular senescence in early placenta development in rats","volume":"610","author":"Leonardi","year":"2025","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"R105-20260706","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.mad.2008.12.006","article-title":"Activation of Akt by lithium: pro-survival pathways in aging","volume":"130","author":"Tajes","year":"2009","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"R106-20260706","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/bph.12496","article-title":"Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1","volume":"171","author":"Arunachalam","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"3","key":"R107-20260706","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/08923973.2022.2143371","article-title":"Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1\/PPAR-gamma, SIRT1\/FOXO-3, JNK\/AP-1, TLR4\/iNOS, and Ang II\/Ang 1-7 signals","volume":"45","author":"Hassanein","year":"2023","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"4","key":"R108-20260706","doi-asserted-by":"crossref","first-page":"e23014","DOI":"10.1002\/dneu.23014","article-title":"Silent synapses in multiple sclerosis: From synaptic dysfunction to reactivation-based therapies-A narrative review of cognitive and neuroplasticity outcomes","volume":"85","author":"Alatawi","year":"2025","journal-title":"Dev Neurobiol"},{"issue":"1","key":"R109-20260706","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2012.01.122","article-title":"Inhibition of JNK\/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer\u2019s disease model","volume":"419","author":"Hong","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"R110-20260706","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41398-025-03775-9","article-title":"Computational biological analysis reveals that HIF-1 and FoxO signaling pathways influence cognitive impairment in patients with depression","volume":"15","author":"Zhuo","year":"2025","journal-title":"Transl Psychiatry"},{"issue":"1","key":"R111-20260706","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12868-025-00965-5","article-title":"Mir-199a-3p aggravates neuroinflammation in an Alzheimer\u2019s disease transgenic mouse model by promoting M1-polarization microgliaMir-199a-3p M1","volume":"26","author":"Wang","year":"2025","journal-title":"BMC Neurosci"},{"key":"R112-20260706","doi-asserted-by":"crossref","first-page":"110588","DOI":"10.1016\/j.fsi.2025.110588","article-title":"FOXO is involved in anti-WSSV immunity by regulating autophagy-related genes","volume":"166","author":"Liu","year":"2025","journal-title":"Fish Shellfish Immunol"},{"issue":"4","key":"R113-20260706","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/biomedicines12040855","article-title":"Aspartame causes developmental defects and teratogenicity in zebra fish embryo: Role of impaired SIRT1\/FOXO3a axis in neuron cells","volume":"12","author":"Pandaram","year":"2024","journal-title":"Biomedicines"},{"key":"R114-20260706","doi-asserted-by":"crossref","first-page":"1290732","DOI":"10.3389\/fphys.2023.1290732","article-title":"DsFoxO knockout affects development and fecundity of Drosophila suzukii","volume":"14","author":"Zhao","year":"2023","journal-title":"Front Physiol"},{"issue":"10","key":"R115-20260706","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/hmg\/dds040","article-title":"Targeting the UPR transcription factor XBP1 protects against Huntington\u2019s disease through the regulation of FoxO1 and autophagy","volume":"21","author":"Vidal","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"5","key":"R116-20260706","doi-asserted-by":"crossref","first-page":"e00382","DOI":"10.1042\/BSR20160174","article-title":"Knockdown of GSK3\u03b2 increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells","volume":"36","author":"Weikel","year":"2016","journal-title":"Biosci Rep"},{"issue":"33","key":"R117-20260706","doi-asserted-by":"crossref","first-page":"e43156","DOI":"10.1097\/MD.0000000000043156","article-title":"Diagnostic value of the iron apoptosis-related gene in recurrent miscarriage","volume":"104","author":"Zheng","year":"2025","journal-title":"Medicine"},{"issue":"23","key":"R118-20260706","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1523\/JNEUROSCI.0363-14.2014","article-title":"TGFbeta signaling regulates the timing of CNS myelination by modulating oligodendrocyte progenitor cell cycle exit through SMAD3\/4\/FoxO1\/Sp1","volume":"34","author":"Palazuelos","year":"2014","journal-title":"J Neurosci"},{"issue":"4","key":"R119-20260706","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.7150\/ijbs.124782","article-title":"FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis","volume":"22","author":"Wang","year":"2026","journal-title":"Int J Biol Sci"},{"key":"R120-20260706","doi-asserted-by":"crossref","first-page":"102957","DOI":"10.1016\/j.arr.2025.102957","article-title":"Serotonin-mediated regulation of mitophagy in Alzheimer\u2019s disease: Mechanistic insights and therapeutic potential","volume":"114","author":"Sultana","year":"2026","journal-title":"Ageing Res Rev"},{"issue":"6","key":"R121-20260706","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41419-019-1695-x","article-title":"Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1\/Parkin-dependent mitophagy","volume":"10","author":"Guo","year":"2019","journal-title":"Cell Death Dis"},{"issue":"3","key":"R122-20260706","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10863-016-9645-0","article-title":"Mitochondrial FOXO3a is involved in amyloid \u03b2 peptide-induced mitochondrial dysfunction","volume":"48","author":"Shi","year":"2016","journal-title":"J Bioenerg Biomembr"},{"key":"R123-20260706","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbi.2015.07.013","article-title":"Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells","volume":"240","author":"Lin","year":"2015","journal-title":"Chem Biol Interact"},{"issue":"2","key":"R124-20260706","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10522-025-10207-0","article-title":"Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging","volume":"26","author":"Gupta","year":"2025","journal-title":"Biogerontology"},{"key":"R125-20260706","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer\u2019s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog Neurobiol"},{"issue":"12","key":"R126-20260706","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.3390\/biom13121782","article-title":"Resilience and vulnerability to stress-induced anhedonia: Unveiling brain gene expression and mitochondrial dynamics in a mouse chronic stress depression model","volume":"13","author":"Strekalova","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"R127-20260706","doi-asserted-by":"crossref","first-page":"31971","DOI":"10.1038\/s41598-025-17606-w","article-title":"Identification and experimental validation of biomarkers related to mitochondrial and programmed cell death in obsessive-compulsive disorder","volume":"15","author":"Mao","year":"2025","journal-title":"Sci Rep"}],"container-title":["Aging Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/AGINGADV.AGINGADV-D-26-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:30:39Z","timestamp":1787769039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/AGINGADV.AGINGADV-D-26-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/agingadv.agingadv-d-26-00011","relation":{},"ISSN":["3050-6735","3050-6743"],"issn-type":[{"value":"3050-6735","type":"print"},{"value":"3050-6743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"2026-03-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}