{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:16Z","timestamp":1786649536243,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cerebral Venous Thrombosis (CVT) poses a rare but life-threatening challenge, warranting meticulous treatment approaches. Traditional therapy involves Vitamin K Antagonists (VKAs), but Newer Oral Anticoagulants (NOACs) offer potential advantages. This study addresses a crucial knowledge gap in the Indian context, analyzing real-world data to guide CVT management decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single-center, ambispective cohort study included consecutive adult CVT patients. Data collection encompassed demographics, clinical data, imaging, and treatment details. Patients were categorized into VKA and NOAC groups. Outcomes measured recanalization status, functional outcomes, bleeding events, and adverse drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 181 enrolled patients, NOAC-treated (Group B) individuals had significantly higher rates of complete recanalization (58.5% vs. 31.1%) with a similar incidence of adverse events and also displayed better functional outcomes at weeks 8 and 12 compared to VKA-treated (Group A) patients. Recurrent thromboembolic events were absent in both groups during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights NOACs\u2019 potential advantages in CVT management, including improved functional outcomes, enhanced recanalization, and similar bleeding risk. Adverse events were milder with NOACs. While acknowledging limitations, these findings support NOACs as a promising alternative to VKAs, advancing CVT care and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_1096_23","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T01:00:19Z","timestamp":1718931619000},"page":"393-397","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Newer Oral Anticoagulants Versus Vitamin K Antagonists in the Management of Cerebral Venous Thrombosis: A Single-Center Ambispective Study from South India"],"prefix":"10.4103","volume":"27","author":[{"given":"Rithvik","family":"Ramesh","sequence":"first","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Narasimhan","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Raguraman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamlesh","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braveen","family":"Rajamanoharan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun Kishore","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philo","family":"Hazeena","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundar","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Avadhani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"e12682","DOI":"10.1002\/rth2.12682","article-title":"Epidemiology of cerebral venous sinus thrombosis and cerebral venous sinus thrombosis with thrombocytopenia in the United States, 2018 and 2019","volume":"6","author":"Payne","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"R2-20260427","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2147\/TCRM.S84210","article-title":"New oral anticoagulants: Their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events","volume":"11","author":"Mekaj","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"R3-20260427","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1001\/jamaneurol.2019.2764","article-title":"Safety and efficacy of dabigatran etexilate vs dose-adjusted warfarin in patients with cerebral venous thrombosis: A randomized clinical trial","volume":"76","author":"Ferro","year":"2019","journal-title":"JAMA Neurol"},{"key":"R4-20260427","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/STROKEAHA.121.037541","article-title":"Direct Oral anticoagulants versus warfarin in the treatment of cerebral venous thrombosis (ACTION-CVT): A multicenter international study","volume":"53","author":"Yaghi","year":"2022","journal-title":"Stroke"},{"key":"R5-20260427","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0028-3886.96388","article-title":"Risk factors, clinical profile, and long-term outcome of 428 patients of cerebral sinus venous thrombosis: Insights from Nizam\u2032s Institute Venous Stroke Registry, Hyderabad (India)","volume":"60","author":"Narayan","year":"2012","journal-title":"Neurol India"},{"key":"R6-20260427","first-page":"349","article-title":"Cerebral venous thrombosis","volume":"35","author":"Parikh","year":"1987","journal-title":"J Assoc Physicians India"},{"key":"R7-20260427","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5853\/jos.2019.00150","article-title":"New oral anticoagulants versus warfarin for cerebral venous thrombosis: A multi-center, observational study","volume":"21","author":"Wasay","year":"2019","journal-title":"J Stroke"},{"key":"R8-20260427","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/STROKEAHA.118.022129","article-title":"Recanalization in cerebral venous thrombosis","volume":"49","author":"Aguiar de Sousa","year":"2018","journal-title":"Stroke"},{"key":"R9-20260427","doi-asserted-by":"crossref","first-page":"100143","DOI":"10.1016\/j.rpth.2023.100143","article-title":"Recanalization and outcomes after cerebral venous thrombosis: A systematic review and meta-analysis","volume":"7","author":"Kim","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"R10-20260427","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/jnnp-2014-310068","article-title":"Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy","volume":"87","author":"Arauz","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_1096_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:09Z","timestamp":1786647309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_1096_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_1096_23","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"2023-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}