{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:43:11Z","timestamp":1792417391037,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Fatigue is a non-motor symptoms (NMS) of Parkinson\u2019s disease (PD). The study aimed to determine the frequency and severity of fatigue, its predictors, and its impact on quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 150 patients with PD. The Fatigue Severity Scale (FSS) and the Parkinson Fatigue Scale\u201316 (PFS-16) were used to assess the presence and severity of fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The frequency of fatigue was 46%, predominantly of mild severity. The mean FSS score was 33.3 \u00b1 10.3. Patients with fatigue were older, had a longer disease duration, received higher levodopa doses, and had greater motor and NMS severity. Anxiety and depression scores were higher, along with a greater frequency of excessive daytime sleepiness and sleep disturbances. Fatigue had a negative impact on quality of life. Multivariate analysis identified disease duration, motor severity, and depression as independent predictors of fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Fatigue is a frequent yet underrecognized NMS in PD. Nearly half of the patients experienced fatigue, mostly of mild severity, and it was associated with longer disease duration, greater disease severity, mood disturbances, sleep-related symptoms, and reduced quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_117_26","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:00:07Z","timestamp":1785913207000},"page":"750-755","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Fatigue in Parkinson\u2019s Disease: A Cross-Sectional Study of Prevalence and Clinical Correlates"],"prefix":"10.4103","volume":"29","author":[{"given":"Pramod","family":"Khanda","sequence":"first","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram V","family":"Holla","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan R","family":"Mahale","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"R1-20261019","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"Dorsey","year":"2007","journal-title":"Neurology"},{"key":"R2-20261019","doi-asserted-by":"crossref","first-page":"1433934","DOI":"10.3389\/fneur.2024.1433934","article-title":"Editorial: New insights in non-motor symptoms in Parkinson's disease","volume":"15","author":"Falup-Pecurariu","year":"2024","journal-title":"Front 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Minor inconvenience or major distress?","volume":"19","author":"Herlofson","year":"2012","journal-title":"Eur J Neurol"},{"key":"R19-20261019","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1212\/WNL.0000000000000587","article-title":"Prevalence of fatigue in Parkinson disease and its clinical correlates","volume":"83","author":"Stocchi","year":"2014","journal-title":"Neurology"},{"key":"R20-20261019","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0404.2010.01364.x","article-title":"Evaluation of fatigue in Parkinson's disease using the Brazilian version of Parkinson's Fatigue Scale","volume":"123","author":"Kummer","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"R21-20261019","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00415-013-7207-5","article-title":"Association between fatigue and other motor and non-motor symptoms in Parkinson's disease patients","volume":"261","author":"Solla","year":"2014","journal-title":"J Neurol"},{"key":"R22-20261019","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000350289","article-title":"Fatigue in drug-na\u00efve Parkinson's disease","volume":"70","author":"Kang","year":"2013","journal-title":"Eur Neurol"},{"key":"R23-20261019","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/brb3.247","article-title":"Clinical evaluation of fatigue in Japanese patients with Parkinson's disease","volume":"4","author":"Tanaka","year":"2014","journal-title":"Brain Behav"},{"key":"R24-20261019","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40035-016-0056-2","article-title":"Clinical characteristics of fatigued Parkinson's patients and the response to dopaminergic treatment","volume":"5","author":"Fu","year":"2016","journal-title":"Transl Neurodegener"},{"key":"R25-20261019","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijge.2016.05.011","article-title":"The relationship between fatigue and other non-motor symptoms in Parkinson's disease in Chinese population","volume":"11","author":"Ding","year":"2017","journal-title":"Int J Gerontol"},{"key":"R26-20261019","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3988\/jcn.2016.12.2.172","article-title":"Parkinson's disease with fatigue: Clinical characteristics and potential mechanisms relevant to \u03b1-synuclein oligomer","volume":"12","author":"Zuo","year":"2016","journal-title":"J Clin Neurol"},{"key":"R27-20261019","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/mds.22731","article-title":"Fatigue in Japanese patients with Parkinson's disease: A study using Parkinson fatigue scale","volume":"24","author":"Okuma","year":"2009","journal-title":"Mov Disord"},{"key":"R28-20261019","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/CM9.0000000000001303","article-title":"Fatigue correlates with sleep disturbances in Parkinson disease","volume":"134","author":"Cao","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"R29-20261019","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2169\/internalmedicine.50.4954","article-title":"Fatigue in patients with Parkinson's disease: Impact on quality of life","volume":"50","author":"Miwa","year":"2011","journal-title":"Intern Med"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_117_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:01:37Z","timestamp":1792414897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_117_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_117_26","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"2026-01-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}