{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:30:22Z","timestamp":1787056222883,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Duchenne muscular dystrophy (DMD) is a common muscular dystrophy of childhood with the devastating consequence of loss of independent ambulation by teenage years and death by the second or third decade. We aimed to determine the prevalence of depression among children with DMD and to explore the relationship of depression with age, socio-demographic parameters, family history, steroid use, and current motor ability of children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a cross-sectional questionnaire survey in 50 boys with DMD (aged 8\u201316 years) in an outpatient clinic. Self-reported symptoms of depression were assessed using the children\u2019s depression rating scale-revised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We observed that 28% of children were clinically depressed, while 12% of children had subthreshold depressive symptoms. The cognitive domain of depression was observed to be the most affected in the majority of study participants. A significant association was found between socioeconomic status, positive family history of DMD, and school difficulties with co-existing depression (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Our results suggest that depression is a common comorbidity in children with DMD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We recommend regular psychological screening and appropriate intervention for every DMD child, with special emphasis on those belonging to extremes of socioeconomic classes and with a positive family history of DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_1323_25","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T08:00:14Z","timestamp":1784275214000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Depression among Children with Duchenne Muscular Dystrophy: A Cross-sectional Survey Study"],"prefix":"10.4103","volume":"29","author":[{"given":"Maddukuri","family":"Sriram","sequence":"first","affiliation":[{"name":"Department of Paediatrics, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelu","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrajesh","family":"Udani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"R1-20260818","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13023-020-01430-8","article-title":"Global epidemiology of Duchenne muscular dystrophy: An updated systematic review and meta-analysis","volume":"15","author":"Crisafulli","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"R2-20260818","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-0033-1347935","article-title":"Self-reported quality of life and depressive symptoms in children, adolescents, and adults with duchenne muscular dystrophy: A cross-sectional survey study","volume":"44","author":"Schmid","year":"2013","journal-title":"Neuropediatrics"},{"key":"R3-20260818","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: The protein product of the Duchenne muscular dystrophy locus","volume":"51","author":"Hoffman","year":"1987","journal-title":"Cell"},{"key":"R4-20260818","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0960-8966(02)00140-2","article-title":"Survival in Duchenne muscular dystrophy: Improvements in life expectancy since 1967 and the impact of home nocturnal ventilation","volume":"12","author":"Eagle","year":"2002","journal-title":"Neuromuscul Disord"},{"key":"R5-20260818","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/0883073818774439","article-title":"Descriptive phenotype of obsessive-compulsive symptoms in males with Duchenne muscular dystrophy","volume":"33","author":"Lee","year":"2018","journal-title":"J Child Neurol"},{"key":"R6-20260818","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/s41467-025-56644-w","article-title":"Duchenne muscular dystrophy: Recent insights in brain related comorbidities","volume":"16","author":"Vaillend","year":"2025","journal-title":"Nat Commun"},{"key":"R7-20260818","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1080\/09638288.2024.2394642","article-title":"The struggle to belong: A qualitative exploration of challenges in social spaces faced by children with Duchenne muscular dystrophy attending neuromuscular disorders clinic","volume":"47","author":"Kumar","year":"2025","journal-title":"Disabil Rehabil"},{"key":"R8-20260818","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/cap.2010.0063","article-title":"Psychometric properties of the children\u2019s depression rating scale\u2013revised in adolescents","volume":"20","author":"Mayes","year":"2010","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"R9-20260818","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0019-5359.94403","article-title":"Validation of the children\u2019s depression rating scale- revised for adolescents in primary-care paediatric use in India","volume":"64","author":"Basker","year":"2010","journal-title":"Indian J Med Sci"},{"key":"R10-20260818","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1024\/1422-4917\/a000090","article-title":"Children\u2019s depression rating scale \u2013 Revised (CDRS-R)","volume":"39","author":"Keller","year":"2011","journal-title":"Z Kinder Jugendpsychiatr Psychother"},{"key":"R11-20260818","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1207\/s15374424jccp2404_8","article-title":"Children\u2019s depression rating scale-revised: Development of a short form","volume":"24","author":"Overholser","year":"1995","journal-title":"J Clin Child Psychol"},{"key":"R12-20260818","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18231\/j.ijfcm.2021.001","article-title":"Modified Kuppuswamy socioeconomic scale updated for the year 2021","volume":"8","author":"Saleem","year":"2021","journal-title":"Indian J Forensic Community Med"},{"key":"R13-20260818","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s13023-021-02008-8","article-title":"Anxiety and depression in school-age patients with spinal muscular atrophy: A cross-sectional study","volume":"16","author":"Yao","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"R14-20260818","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1440-1754.2011.02022.x","article-title":"Health status of boys with Duchenne muscular dystrophy: A parent\u2019s perspective","volume":"47","author":"Bray","year":"2011","journal-title":"J Paediatr Child Health"},{"key":"R15-20260818","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.apmr.2015.02.012","article-title":"Prevalence of fatigue, pain, and affective disorders in adults with Duchenne muscular dystrophy and their associations with quality of life","volume":"96","author":"Pangalila","year":"2015","journal-title":"Arch Phys Med Rehabil"},{"key":"R16-20260818","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1477-7525-10-43","article-title":"Participation and quality of life in children with Duchenne muscular dystrophy using the international classification of functioning, disability, and health","volume":"10","author":"Bendixen","year":"2012","journal-title":"Health Qual Life Outcomes"},{"key":"R17-20260818","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/jfmpc.jfmpc_248_17","article-title":"Prevalence of depression and anxiety among children in rural and suburban areas of Eastern Uttar Pradesh: A crosssectional study","volume":"7","author":"Mishra","year":"2018","journal-title":"J Family Med Prim Care"},{"key":"R18-20260818","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/DBP.0000000000000177","article-title":"Neurobehavioral concerns among males with dystrophinopathy using population-based surveillance data from the muscular dystrophy surveillance, tracking, and research network","volume":"36","author":"Caspers","year":"2015","journal-title":"J Dev Behav Pediatr"},{"key":"R19-20260818","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/0883073817701368","article-title":"Secondary conditions among males with Duchenne or Becker muscular dystrophy","volume":"32","author":"Latimer","year":"2017","journal-title":"J Child Neurol"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_1323_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:01:11Z","timestamp":1787054471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_1323_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_1323_25","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}