{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:40Z","timestamp":1787070760598,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Small fiber neuropathy cannot be detected using conventional nerve conduction studies. The use of the cutaneous silent period (CSP) could represent an effective non-invasive test in evaluating the small nerve fibers. The current work aimed to evaluate the CSP among healthy individuals across different decades and assess the effect of gender on CSP values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>71 healthy volunteers with an age range of 20-60 years were included in this study. Several CSP parameters were measured, including CSP latencies and duration of the median, ulnar, and sural nerves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We obtained the mean CSP parameters for the mentioned upper and lower limb nerves across different decades. Age had a significant impact on CSP latencies. Males showed longer latencies than females. No significant inter-side CSP difference was noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The CSP test is a non-invasive tolerable test and could serve as an important addition to routine electrophysiological examination. The age and gender significantly impact the CSP latency. The establishment of normative data and an understanding of the effects of age and gender is essential for proper employment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_165_25","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T10:00:13Z","timestamp":1755165613000},"page":"718-724","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Small Nerve Fibers Using the Cutaneous Silent Period: Effect of Age and Gender"],"prefix":"10.4103","volume":"28","author":[{"given":"Sarah M","family":"Kaddah","sequence":"first","affiliation":[{"name":"Clinical Neurophysiology Unit, Department of Neurology and Clinical Neurophysiology, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Afifi","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Unit, Department of Neurology and Clinical Neurophysiology, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Raafat","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Unit, Department of Neurology and Clinical Neurophysiology, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alshaimaa Sobhi","family":"Khalil","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Unit, Department of Neurology and Clinical Neurophysiology, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"issue":"Suppl 2","key":"R1-20251112","first-page":"ii23","article-title":"Nerve conduction studies: Essentials and pitfalls in practice","volume":"76","author":"Mallik","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R2-20251112","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5455\/medarh.2019.73.326-330","article-title":"Diabetes mellitus type has impact on cutaneous silent period","volume":"73","author":"Drnda","year":"2019","journal-title":"Med Arch"},{"key":"R3-20251112","first-page":"300","article-title":"Electrophysiology of small peripheral nerve fibers in man. A study using the cutaneous silent period","volume":"42","author":"Svilpauskaite","year":"2006","journal-title":"Medicina (Kaunas)"},{"key":"R5-20251112","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.clinph.2010.03.012","article-title":"Utility of the cutaneous silent period in the evaluation of carpal tunnel syndrome","volume":"121","author":"Koo","year":"2010","journal-title":"Clin Neurophysiol"},{"key":"R6-20251112","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00221-015-4329-2","article-title":"Temporal profile of the effects of regional anesthesia on the cutaneous reflexes of foot muscles","volume":"233","author":"Mota","year":"2015","journal-title":"Exp Brain Res"},{"key":"R7-20251112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0149248","article-title":"Lengthened cutaneous silent period in fibromyalgia suggesting central sensitization as a pathogenesis","volume":"11","author":"Baek","year":"2016","journal-title":"PLoS One"},{"key":"R8-20251112","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.clinph.2014.11.013","article-title":"Cutaneous silent period recordings in demyelinating and axonal polyneuropathies","volume":"126","author":"Lopergolo","year":"2015","journal-title":"Clin Neurophysiol"},{"key":"R9-20251112","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/mus.25203","article-title":"Electrodiagnostic reference values for upper and lower limb nerve conduction studies in adult populations","volume":"54","author":"Chen","year":"2016","journal-title":"Muscle Nerve"},{"key":"R11-20251112","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.clinph.2004.04.014","article-title":"Interside comparison of cutaneous silent periods in thenar muscles of healthy male and female subjects","volume":"115","author":"Kofler","year":"2004","journal-title":"Clin Neurophysiol"},{"key":"R12-20251112","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5455\/medarh.2014.68.98-101","article-title":"Cutaneous silent period in the evaluation of small nerve fibres","volume":"68","author":"Tiric-Campara","year":"2014","journal-title":"Med Arch"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_165_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:09Z","timestamp":1787067369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_165_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_165_25","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"assertion":[{"value":"2025-02-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}