{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:26Z","timestamp":1786653566006,"version":"build-2736575974"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Ketogenic dietary therapies (KDTs) have been in use for refractory paediatric epilepsy for a century now. Over time, KDTs themselves have undergone various modifications to improve tolerability and clinical feasibility, including the Modified Atkins diet (MAD), medium chain triglyceride (MCT) diet and the low glycaemic index treatment (LGIT). Animal and observational studies indicate numerous benefits of KDTs in paediatric neurological conditions apart from their evident benefits in childhood intractable epilepsy, including neurodevelopmental disorders such as autism spectrum disorder, rarer neurogenetic conditions such as Rett syndrome, Fragile X syndrome and Kabuki syndrome, neurodegenerative conditions such as Pelizaeus-Merzbacher disease, and other conditions such as stroke and migraine. A large proportion of the evidence is derived from individual case reports, case series and some small clinical trials, emphasising the vast scope for research in this avenue. The term 'neuroketotherapeutics' has been coined recently to encompass the rapid strides in this field. In the 100\n                      <jats:sup>th<\/jats:sup>\n                      year of its use for paediatric epilepsy, this review covers the role of the KDTs in non-epilepsy neurological conditions among children.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_20_21","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T07:59:22Z","timestamp":1620719962000},"page":"470-480","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Emerging Role of the Ketogenic Dietary Therapies beyond Epilepsy in Child Neurology"],"prefix":"10.4103","volume":"24","author":[{"given":"Dipti","family":"Kapoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvasini","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240828","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.0013-9580.2005.42704.x","article-title":"Worldwide use of the ketogenic diet","volume":"46","author":"Kossoff","year":"2005","journal-title":"Epilepsia"},{"key":"R2-4-20240828","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/0883073813487601","article-title":"Use of dietary therapy for status epilepticus","volume":"28","author":"Kossoff","year":"2013","journal-title":"J Child Neurol"},{"key":"R3-4-20240828","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/14737175.2017.1260004","article-title":"Ketogenic diet and childhood neurological disorders other than epilepsy: An overview","volume":"17","author":"Verrotti","year":"2017","journal-title":"Expert Rev Neurother"},{"key":"R4-4-20240828","doi-asserted-by":"crossref","first-page":"109947","DOI":"10.1016\/j.pnpbp.2020.109947","article-title":"Mental, emotional, and behavioral effects of ketogenic diet for non-epileptic neuropsychiatric conditions","volume":"102","author":"Grigolon","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R5-4-20240828","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuint.2017.05.019","article-title":"Neuroketotherapeutics: A modern review of a century-old therapy","volume":"117","author":"Koppel","year":"2018","journal-title":"Neurochem Int"},{"key":"R6-4-20240828","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.plefa.2003.09.007","article-title":"The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism","volume":"70","author":"Veech","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"R7-4-20240828","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1194\/jlr.R046599","article-title":"Ketone body therapy: From the ketogenic diet to the oral administration of ketone ester","volume":"55","author":"Hashim","year":"2014","journal-title":"J Lipid Res"},{"key":"R8-4-20240828","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/aur.1682","article-title":"Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf\/J mouse model of autism spectrum disorder","volume":"10","author":"Mychasiuk","year":"2017","journal-title":"Autism Res"},{"key":"R9-4-20240828","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1177\/0883073813488668","article-title":"Autism and dietary therapy: Case report and review of the literature","volume":"28","author":"Herbert","year":"2013","journal-title":"J Child Neurol"},{"key":"R10-4-20240828","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnmol.2017.00034","article-title":"Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches","volume":"10","author":"Cheng","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"R11-4-20240828","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/mp.2010.136","article-title":"Mitochondrial dysfunction in autism spectrum disorders: A systematic review and meta-analysis","volume":"17","author":"Rossignol","year":"2012","journal-title":"Mol Psychiatry"},{"key":"R12-4-20240828","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.physbeh.2016.04.001","article-title":"Ketogenic diet exposure during the juvenile period increases social behaviors and forebrain neural activation in adult Engrailed 2 null mice","volume":"161","author":"Verpeut","year":"2016","journal-title":"Physiol Behav"},{"key":"R13-4-20240828","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2016.02.015","article-title":"Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder","volume":"304","author":"Smith","year":"2016","journal-title":"Behav Brain Res"},{"key":"R14-4-20240828","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13229-016-0099-3","article-title":"Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder","volume":"7","author":"Newell","year":"2016","journal-title":"Mol Autism"},{"key":"R15-4-20240828","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/08830738030180020501","article-title":"Application of a ketogenic diet in children with autistic behavior: Pilot study","volume":"18","author":"Evangeliou","year":"2003","journal-title":"J Child Neurol"},{"key":"R16-4-20240828","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.physbeh.2018.02.006","article-title":"A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder","volume":"188","author":"Lee","year":"2018","journal-title":"Physiol Behav"},{"key":"R17-4-20240828","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/acs.jproteome.9b00581","article-title":"Metabolic framework for the improvement of autism spectrum disorders by a modified ketogenic diet: A pilot study","volume":"19","author":"Mu","year":"2020","journal-title":"J Proteome Res"},{"key":"R18-4-20240828","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s11011-017-0088-z","article-title":"Ketogenic diet versus gluten free casein free diet in autistic children: A case-control study","volume":"32","author":"El-Rashidy","year":"2017","journal-title":"Metab Brain Dis"},{"key":"R19-4-20240828","first-page":"1038","article-title":"[Prospective study of ketogenic diet in treatment of children with global developmental delay]","volume":"19","author":"Zhu","year":"2017","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"R20-4-20240828","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yebeh.2015.11.014","article-title":"Effects of a ketogenic diet on ADHD-like behavior in dogs with idiopathic epilepsy","volume":"55","author":"Packer","year":"2016","journal-title":"Epilepsy Behav"},{"key":"R21-4-20240828","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1469-8749.2001.tb00209.x","article-title":"Effects of ketogenic diet on development and behavior: Preliminary report of a prospective study","volume":"43","author":"Pulsifer","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"R22-4-20240828","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neuron.2015.03.042","article-title":"The GABAA receptor as a therapeutic target for neurodevelopmental disorders","volume":"86","author":"Braat","year":"2015","journal-title":"Neuron"},{"key":"R23-4-20240828","doi-asserted-by":"crossref","first-page":"a022780","DOI":"10.1101\/cshperspect.a022780","article-title":"Mechanisms of action of antiseizure drugs and the ketogenic diet","volume":"6","author":"Rogawski","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R24-4-20240828","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"Chao","year":"2010","journal-title":"Nature"},{"key":"R25-4-20240828","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.seizure.2011.06.009","article-title":"Long-term follow-up of the ketogenic diet for refractory epilepsy: Multicenter Argentinean experience in 216 pediatric patients","volume":"20","author":"Caraballo","year":"2011","journal-title":"Seizure"},{"key":"R26-4-20240828","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yebeh.2009.02.038","article-title":"Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets","volume":"15","author":"Mantis","year":"2009","journal-title":"Epilepsy Behav"},{"key":"R27-4-20240828","doi-asserted-by":"crossref","first-page":"104687","DOI":"10.1016\/j.neuint.2020.104687","article-title":"Preclinical testing of the ketogenic diet in fragile X mice","volume":"134","author":"Westmark","year":"2020","journal-title":"Neurochem Int"},{"key":"R28-4-20240828","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-genom-090613-094245","article-title":"Mendelian disorders of the epigenetic machinery: Tipping the balance of chromatin states","volume":"15","author":"Fahrner","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"R29-4-20240828","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"R30-4-20240828","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1073\/pnas.1611431114","article-title":"A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome","volume":"114","author":"Benjamin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R31-4-20240828","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13023-020-01412-w","article-title":"The modified Atkins diet in children with Prader-Willi syndrome","volume":"15","author":"Felix","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"R32-4-20240828","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fcell.2017.00043","article-title":"Metabolic reprogramming in glioma","volume":"5","author":"Strickland","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"R33-4-20240828","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1194\/jlr.R046797","article-title":"The ketogenic diet for the treatment of malignant glioma","volume":"56","author":"Woolf","year":"2015","journal-title":"J Lipid Res"},{"key":"R34-4-20240828","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"key":"R35-4-20240828","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1743-7075-8-54","article-title":"Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial","volume":"8","author":"Schmidt","year":"2011","journal-title":"Nutr Metab (Lond"},{"key":"R36-4-20240828","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fnins.2020.00390","article-title":"Exploring the feasibility and effects of a ketogenic diet in patients with CNS malignancies: A retrospective case series","volume":"14","author":"Panhans","year":"2020","journal-title":"Front Neurosci"},{"key":"R37-4-20240828","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/07315724.1995.10718495","article-title":"Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: Two case reports","volume":"14","author":"Nebeling","year":"1995","journal-title":"J Am Coll Nutr"},{"key":"R38-4-20240828","doi-asserted-by":"crossref","first-page":"CNS17","DOI":"10.2217\/cns-2017-0030","article-title":"The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: A systematic review","volume":"7","author":"Martin-McGill","year":"2018","journal-title":"CNS Oncol"},{"key":"R39-4-20240828","doi-asserted-by":"crossref","first-page":"e27561","DOI":"10.1002\/pbc.27561","article-title":"Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: A safety and feasibility study","volume":"66","author":"van der Louw","year":"2019","journal-title":"Pediatr Blood Cancer"},{"key":"R40-4-20240828","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.braindev.2009.04.009","article-title":"Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet","volume":"32","author":"Chu-Shore","year":"2010","journal-title":"Brain Dev"},{"key":"R41-4-20240828","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.yebeh.2014.08.015","article-title":"Does ketogenic diet improve cognitive function in patients with GLUT1-DS? A 6- to 17-month follow-up study","volume":"39","author":"Ramm-Pettersen","year":"2014","journal-title":"Epilepsy Behav"},{"key":"R42-4-20240828","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/dmcn.13167","article-title":"Use of modified Atkins diet in glucose transporter type 1 deficiency syndrome","volume":"58","author":"Amalou","year":"2016","journal-title":"Dev Med Child Neurol"},{"key":"R43-4-20240828","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10545-016-0011-5","article-title":"Ketogenic diet in pyruvate dehydrogenase complex deficiency: Short- and long-term outcomes","volume":"40","author":"Sofou","year":"2017","journal-title":"J Inherit Metab Dis"},{"key":"R44-4-20240828","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ana.20565","article-title":"Treatment of glycogenosis type V with ketogenic diet","volume":"58","author":"Busch","year":"2005","journal-title":"Ann Neurol"},{"key":"R45-4-20240828","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/jimd.12223","article-title":"Titrating a modified ketogenic diet for patients with McArdle disease: A pilot study","volume":"43","author":"L\u00f8kken","year":"2020","journal-title":"J Inherit Metab Dis"},{"key":"R46-4-20240828","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1528-1167.2007.00915.x","article-title":"Anticonvulsant mechanisms of the ketogenic diet","volume":"48","author":"Bough","year":"2007","journal-title":"Epilepsia"},{"key":"R47-4-20240828","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s00415-008-0032-6","article-title":"Subacute sclerosing panencephalitis","volume":"255","author":"Garg","year":"2008","journal-title":"J Neurol"},{"key":"R48-4-20240828","first-page":"e5485","article-title":"Substantial remission in subacute sclerosing panencephalitis by following the ketogenic diet: A case report","volume":"11","author":"Nathan","year":"2019","journal-title":"Cureus"},{"key":"R49-4-20240828","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1059-1311(02)00268-6","article-title":"The use of the ketogenic diet in a patient with subacute sclerosing panencephalitis","volume":"12","author":"Bautista","year":"2003","journal-title":"Seizure"},{"key":"R50-4-20240828","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.eplepsyres.2006.01.007","article-title":"A pilot study of a ketogenic diet in patients with Lafora body disease","volume":"69","author":"Cardinali","year":"2006","journal-title":"Epilepsy Res"},{"key":"R51-4-20240828","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2174\/138920111795542633","article-title":"Therapeutic approaches to the challenge of neuronal ceroid lipofuscinoses","volume":"12","author":"Kohan","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"R53-4-20240828","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nm.2833","article-title":"Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet","volume":"18","author":"Saher","year":"2012","journal-title":"Nat Med"},{"key":"R54-4-20240828","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00401-019-01985-2","article-title":"Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease","volume":"138","author":"Stumpf","year":"2019","journal-title":"Acta Neuropathol"},{"key":"R55-4-20240828","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pediatrneurol.2019.10.003","article-title":"Management of alternating hemiplegia of childhood: A review","volume":"103","author":"Samanta","year":"2020","journal-title":"Pediatr Neurol"},{"key":"R56-4-20240828","first-page":"7","article-title":"Excellent response to a ketogenic diet in a patient with alternating hemiplegia of childhood","volume":"15","author":"Roubergue","year":"2014","journal-title":"JIMD Rep"},{"key":"R57-4-20240828","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.braindev.2018.01.002","article-title":"ATP1A3-related epileptic encephalopathy responding to ketogenic diet","volume":"40","author":"Schirinzi","year":"2018","journal-title":"Brain Dev"},{"key":"R58-4-20240828","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2014.06.014","article-title":"Clinical and genetic analysis in alternating hemiplegia of childhood: Ten new patients from Southern Europe","volume":"344","author":"Vila-Pueyo","year":"2014","journal-title":"J Neurol Sci"},{"key":"R59-4-20240828","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/neu.2008.0664","article-title":"The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat","volume":"26","author":"Appelberg","year":"2009","journal-title":"J Neurotrauma"},{"key":"R60-4-20240828","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/jnr.21628","article-title":"Fasting is neuroprotective following traumatic brain injury","volume":"86","author":"Davis","year":"2008","journal-title":"J Neurosci Res"},{"key":"R61-4-20240828","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1089\/neu.2011.1822","article-title":"Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury","volume":"28","author":"Deng-Bryant","year":"2011","journal-title":"J Neurotrauma"},{"key":"R62-4-20240828","first-page":"E746","article-title":"Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia","volume":"270","author":"Hasselbalch","year":"1996","journal-title":"Am J Physiol"},{"key":"R63-4-20240828","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1177\/0271678X15610584","article-title":"Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity","volume":"36","author":"Greco","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"R64-4-20240828","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3171\/jns.1991.74.1.0043","article-title":"The effect of glucose administration on carbohydrate metabolism after head injury","volume":"74","author":"Robertson","year":"1991","journal-title":"J Neurosurg"},{"key":"R65-4-20240828","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/neu.1996.13.473","article-title":"Evaluation of a carbohydrate-free diet for patients with severe head injury","volume":"13","author":"Ritter","year":"1996","journal-title":"J Neurotrauma"},{"key":"R66-4-20240828","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroscience.2006.11.065","article-title":"Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation","volume":"145","author":"Maalouf","year":"2007","journal-title":"Neuroscience"},{"key":"R67-4-20240828","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2009.06.060","article-title":"Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease","volume":"1286","author":"Cheng","year":"2009","journal-title":"Brain Res"},{"key":"R68-4-20240828","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/jcbfm.2015.1","article-title":"Protection of hypoglycemia-induced neuronal death by \u03b2-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species","volume":"35","author":"Julio-Amilpas","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"R69-4-20240828","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.024","article-title":"Early motor-behavioral outcome of ischemic stroke with ketogenic diet preconditioning: Interventional animal study","volume":"28","author":"Shaafi","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R70-4-20240828","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2017.04.010","article-title":"Ischemic preconditioning with a ketogenic diet improves brain ischemic tolerance through increased extracellular adenosine levels and hypoxia-inducible factors","volume":"1667","author":"Yang","year":"2017","journal-title":"Brain Res"},{"key":"R71-4-20240828","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/head.12952","article-title":"Diet and headache: Part 2","volume":"56","author":"Martin","year":"2016","journal-title":"Headache"},{"key":"R72-4-20240828","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2008.01.032","article-title":"Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats","volume":"434","author":"de Almeida Rabello Oliveira","year":"2008","journal-title":"Neurosci Lett"},{"key":"R73-4-20240828","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.20899","article-title":"Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet","volume":"60","author":"Bough","year":"2006","journal-title":"Ann Neurol"},{"key":"R74-4-20240828","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jns.2010.05.017","article-title":"Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation","volume":"295","author":"Urbizu","year":"2010","journal-title":"J Neurol Sci"},{"key":"R75-4-20240828","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/ene.12550","article-title":"Migraine improvement during short lasting ketogenesis: A proof-of-concept study","volume":"22","author":"Di Lorenzo","year":"2015","journal-title":"Eur J Neurol"},{"key":"R76-4-20240828","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s10194-016-0650-9","article-title":"Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: A multimodal evoked potentials study","volume":"17","author":"Di Lorenzo","year":"2016","journal-title":"J Headache Pain"},{"key":"R77-4-20240828","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.expneurol.2006.03.024","article-title":"The ketogenic diet causes a reversible decrease in activity level in Long-Evans rats","volume":"201","author":"Murphy","year":"2006","journal-title":"Exp Neurol"},{"key":"R78-4-20240828","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1203\/01.PDR.0000150804.18038.79","article-title":"Effect of the ketogenic diet on the activity level of Wistar rats","volume":"57","author":"Murphy","year":"2005","journal-title":"Pediatr Res"},{"key":"R79-4-20240828","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajmg.1320250525","article-title":"Therapeutic effects of a ketogenic diet in Rett syndrome","volume":"1","author":"Haas","year":"1986","journal-title":"Am J Med Genet Suppl"},{"key":"R80-4-20240828","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.pediatrneurol.2013.11.017","article-title":"Alternating hemiplegia of childhood with a de novo mutation in ATP1A3 and changes in SLC2A1 responsive to a ketogenic diet","volume":"50","author":"Ulate-Campos","year":"2014","journal-title":"Pediatr Neurol"},{"key":"R81-4-20240828","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/epi4.12225","article-title":"Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group","volume":"3","author":"Kossoff","year":"2018","journal-title":"Epilepsia Open"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.AIAN_20_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:24Z","timestamp":1786649964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.AIAN_20_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_20_21","relation":{},"ISSN":["0972-2327"],"issn-type":[{"value":"0972-2327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}