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This case involves a 63-year-old female with CLL undergoing chemotherapy for a year, who recently presented with unusual eye movements in the horizontal plane (ocular flutter), resting and intentional tremors in the right upper and lower limbs, and intermittent jaw movements. With no established protocol for CLL with central nervous system involvement, collecting case data becomes crucial for determining optimal treatment and diagnostic approaches early on.<\/jats:p>","DOI":"10.4103\/aian.aian_22_24","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T01:00:12Z","timestamp":1718931612000},"page":"313-315","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Navigating the Uncharted: A Rare Case of Ocular Flutter and Intermittent Jaw Movements in a Case of Chronic Lymphoid Leukemia"],"prefix":"10.4103","volume":"27","author":[{"given":"Kunal","family":"Arora","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunjeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fortis Hospital, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/ajh.26367","article-title":"Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures","volume":"96","author":"Hallek","year":"2021","journal-title":"Am J Hematol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4103\/0301-4738.169789","article-title":"Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India","volume":"63","author":"Koshy","year":"2015","journal-title":"Indian J Ophthalmol"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0039-6257(83)90123-6","article-title":"Ocular and orbital involvement in leukemia","volume":"27","author":"Kincaid","year":"1983","journal-title":"Surv Ophthalmol"},{"key":"R4-20240828","first-page":"475","article-title":"Diagnosis of nystagmus and saccadic intrusion","author":"Leigh","year":"2006","journal-title":"The Neurology of Eye Movements"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/jnnp.2006.107797","article-title":"Unidirectional ocular flutter","volume":"78","author":"Verhaeghe","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.clml.2011.10.005","article-title":"Spectrum of neurologic complications in chronic lymphocytic leukemia","volume":"12","author":"Lopes da Silva","year":"2012","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"R7-20240828","first-page":"209","article-title":"CNS involvement in leukaemia. 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