{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:49:53Z","timestamp":1787071793223,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>While the systemic features of dengue are well-documented, its neuromuscular manifestations remain under-characterized. We aimed to systematically review the published literature on the spectrum, clinical features, diagnostics, management, and outcomes of neuromuscular complications associated with dengue infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed, Embase, Scopus, and Google Scholar up to March 9, 2025. Case reports, case series, and observational studies reporting individual-level data on dengue-associated neuromuscular complications were included. Data extraction and quality assessment were performed independently by multiple reviewers, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework was followed. The protocol was registered with PROSPERO (Registration ID: CRD420251008871).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 137 articles describing 171 individual patient cases were included. Guillain-Barr\u00e9 syndrome (n = 57), myositis\/myopathy (n = 38), rhabdomyolysis (n = 24), and hypokalemia-induced paralysis (n = 31) were the most commonly reported manifestations. Less frequent complications included mononeuropathies, radiculopathy\/plexopathy, and neuromuscular junction disorders. Most cases were reported from South and Southeast Asia. The majority of patients responded well to supportive or immunomodulatory therapies. The overall prognosis was favorable, with full or near-complete recovery in most cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dengue can cause a wide range of neuromuscular complications, often requiring early recognition and targeted management. Clinicians should be aware of these manifestations, especially in endemic regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_343_25","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T17:00:56Z","timestamp":1765386056000},"page":"798-805","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Spectrum of Neuromuscular Manifestations in Dengue: A Systematic Review of Case Reports and Case Series"],"prefix":"10.4103","volume":"28","author":[{"given":"Ravindra Kumar","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Neurology, Era\u2019s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza A","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep S","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Neurology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"R2-20251222","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(13)70150-9","article-title":"Neurological complications of dengue virus infection","volume":"12","author":"Carod-Artal","year":"2013","journal-title":"Lancet Neurol"},{"key":"R3-20251222","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/v16091367","article-title":"Central and peripheral nervous system manifestations associated with dengue illness","volume":"16","author":"Guzman","year":"2024","journal-title":"Viruses"},{"key":"R4-20251222","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11910-022-01213-7","article-title":"Neurological complications of dengue fever","volume":"22","author":"Trivedi","year":"2022","journal-title":"Curr Neurol Neurosci Rep"},{"key":"R5-20251222","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/postmj\/qgad004","article-title":"Central nervous system manifestations of dengue infection: Data from a tertiary care Centre in South India","volume":"99","author":"George","year":"2023","journal-title":"Postgrad Med J"},{"key":"R7-20251222","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid Based Med"},{"key":"R8-20251222","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ajog.2020.04.013","article-title":"Coronavirus disease 2019 during pregnancy: A systematic review of reported cases","volume":"223","author":"Della","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"R9-20251222","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-025-03383-w","article-title":"Decoding dengue\u2019s neurological assault: Insights from single-cell CNS analysis in an immunocompromised mouse model","volume":"22","author":"Qiu","year":"2025","journal-title":"J Neuroinflammation"},{"key":"R10-20251222","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/brain\/awad415","article-title":"Dengue virus infection and neurological manifestations: An update","volume":"147","author":"Fong","year":"2024","journal-title":"Brain"},{"key":"R11-20251222","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/s13104-015-1672-0","article-title":"Guillain-Barre syndrome following dengue fever and literature review","volume":"8","author":"Ralapanawa","year":"2015","journal-title":"BMC Res Notes"},{"key":"R12-20251222","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jns.2014.03.016","article-title":"Dengue-associated hypokalemic paralysis: Causal or incidental?","volume":"340","author":"Malhotra","year":"2014","journal-title":"J Neurol Sci"},{"key":"R13-20251222","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jns.2010.10.022","article-title":"Acute dengue virus myositis: A report of seven patients of varying clinical severity including two cases with severe fulminant myositis","volume":"300","author":"Paliwal","year":"2011","journal-title":"J Neurol Sci"},{"key":"R14-20251222","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4269\/ajtmh.14-0343","article-title":"Clinical features of and risk factors for rhabdomyolysis among adult patients with dengue virus infection","volume":"92","author":"Huang","year":"2015","journal-title":"Am J Trop Med Hyg"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_343_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:55:48Z","timestamp":1787068548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_343_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_343_25","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-04-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}