{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:43:12Z","timestamp":1792417392920,"version":"4.4.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Celiac disease is an immune-mediated systemic disorder triggered by gluten exposure in genetically predisposed individuals. Epilepsy has been reported among the neurological manifestations associated with celiac disease; however, the relationship between epilepsy and celiac disease remains incompletely understood, and their coexistence does not necessarily imply causality. This ten-patient case series describes the clinical, electroencephalographic, and follow-up characteristics of children with both epilepsy and celiac disease. Seven patients had focal epilepsy, whereas three had generalized epilepsy phenotypes, including presumed juvenile myoclonic epilepsy, presumed juvenile absence epilepsy, and sleep-related generalized tonic-clonic seizures. Electroencephalography most commonly demonstrated posterior epileptiform abnormalities. Following initiation of a gluten-free diet and appropriate antiseizure medication, seizure freedom was achieved in all patients during follow-up. These findings suggest that epilepsy may occur in children with celiac disease and that favorable outcomes may be observed after dietary treatment. However, the present data should be interpreted as an association rather than evidence of causality.<\/jats:p>","DOI":"10.4103\/aian.aian_411_26","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:00:10Z","timestamp":1791604810000},"page":"845-851","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Epilepsy in Children with Celiac Disease: Clinical and Electroencephalographic Characteristics and Outcomes in a Ten-Patient Case Series"],"prefix":"10.4103","volume":"29","author":[{"given":"Sedat","family":"I\u015f\u0131kay","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Medicalpoint Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Demir\u00e7ubuk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medicalpoint Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medicalpoint Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurg\u00fcl","family":"I\u015f\u0131kay","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, \u015eehitkamil Government Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"G\u00fcl\u015fan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medicalpoint Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"R1-20261019","first-page":"2375","article-title":"Celiac disease: An updated overview","volume":"399","author":"Catassi","year":"2022","journal-title":"Lancet"},{"key":"R2-20261019","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","article-title":"European society paediatric gastroenterology, hepatology and nutrition guidelines for diagnosing coeliac disease 2020","volume":"70","author":"Husby","year":"2020","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R3-20261019","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1590\/S0004-28032015000300002","article-title":"The neurological face of celiac disease","volume":"52","author":"I\u015fikay","year":"2015","journal-title":"Arq Gastroenterol"},{"key":"R4-20261019","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1469-8749.2010.03647.x","article-title":"The neurology of coeliac disease in childhood: What is the evidence? A systematic review and meta-analysis","volume":"52","author":"Lionetti","year":"2010","journal-title":"Dev Med Child Neurol"},{"key":"R5-20261019","doi-asserted-by":"crossref","first-page":"1734323","DOI":"10.3389\/fped.2026.1734323","article-title":"Epilepsy and coeliac disease in children: A narrative review","volume":"14","author":"Lonoce","year":"2026","journal-title":"Front Pediatr"},{"key":"R6-20261019","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/epi.17240","article-title":"International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: Position statement by the ILAE task force on nosology and definitions","volume":"63","author":"Riney","year":"2022","journal-title":"Epilepsia"},{"key":"R7-20261019","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s13312-025-00120-7","article-title":"ILAE 2025 classification of epileptic seizures: Key revisions and implications for clinical practice","volume":"62","author":"Ragunathan","year":"2025","journal-title":"Indian Pediatr"},{"key":"R8-20261019","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R9-20261019","first-page":"280","article-title":"Prevalence of celiac disease in Turkish children with idiopathic epilepsy","volume":"24","author":"I\u015fikay","year":"2014","journal-title":"Iran J Pediatr"},{"key":"R10-20261019","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/diseases10040111","article-title":"A comprehensive review of the neurological manifestations of celiac disease and its treatment","volume":"10","author":"Gala","year":"2022","journal-title":"Diseases"},{"key":"R11-20261019","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1651-2227.1991.tb11906.x","article-title":"Coeliac disease, folk acid deficiency and epilepsy with cerebral calcifications","volume":"80","author":"Ventura","year":"1991","journal-title":"Acta Paediatr Scand"},{"key":"R12-20261019","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1046\/j.1528-1157.2001.45700.x","article-title":"Silent celiac disease in patients with childhood localization-related epilepsies","volume":"42","author":"Labate","year":"2001","journal-title":"Epilepsia"},{"key":"R13-20261019","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pediatrneurol.2021.03.003","article-title":"Celiac disease in children: An association with drug-resistant epilepsy","volume":"120","author":"Swartwood","year":"2021","journal-title":"Pediatr Neurol"},{"key":"R14-20261019","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/jcm14030725","article-title":"Effects of a gluten-free diet on brain bioelectrical activity and neurological symptoms in children with celiac disease: A study using EEG assessment","volume":"14","author":"Zochwska-Sobaniec","year":"2025","journal-title":"J Clin Med"},{"key":"R15-20261019","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pediatrneurol.2015.02.006","article-title":"The frequency of epileptiform discharges in celiac disease","volume":"53","author":"I\u015f\u0131kay","year":"2015","journal-title":"Pediatr Neurol"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_411_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:01:45Z","timestamp":1792414905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_411_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_411_26","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}