{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:27:15Z","timestamp":1787840835840,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"\n Background and Objectives:<\/jats:title>\n \n Toll-like receptor (\n TLR2<\/jats:italic>\n ) gene plays an important role in the pathogenesis of bacterial meningitis (such as meningococcal meningitis and pneumococcal meningitis). The association between\n TLR4<\/jats:italic>\n rs4986790 polymorphism and the susceptibility to bacterial meningitis has been extensively studied. However, the results of these studies remain inconsistent. Therefore, we performed a meta-analysis to evaluate the association between\n TLR4<\/jats:italic>\n rs4986790 polymorphism and the susceptibility to meningococcal meningitis and pneumococcal meningitis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Google Scholar, Embase, and PubMed databases were searched for case\u2013control studies on\n TLR4<\/jats:italic>\n polymorphisms and the risks of meningococcal meningitis and pneumococcal meningitis, published up to May 31, 2024. To assess the strength of the association between\n TLR4<\/jats:italic>\n polymorphism and meningococcal meningitis and pneumococcal meningitis, the odds ratios (ORs) with 95% confidence intervals (CIs) were used. The meta-analysis of the associations between the\n TLR4<\/jats:italic>\n rs4986790 polymorphism and meningococcal meningitis and pneumococcal meningitis was carried out under different genetic models. Meta-analyses were conducted using Cochrane RoB 2 tool and Metagenyo to calculate the ORs and 95% CIs. Fourteen published studies with 3599 cases and 7438 controls were included.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Overall, there was a strong correlation between TLR4 polymorphisms and meningococcal meningitis observed across three genetic models using a random-effects model: GG + GA vs. AA (OR: 0.34, 95% CI: 0.14\u20130.79,\n P<\/jats:italic>\n = 0.01,\n I<\/jats:italic>\n \u00b2 = 60%); GA vs. AA (OR: 0.34, 95% CI: 0.13\u20130.91,\n P<\/jats:italic>\n = 0.03,\n I<\/jats:italic>\n \u00b2 = 65%); and GG vs. AA (OR: 0.34, 95% CI: 0.14\u20130.78,\n P<\/jats:italic>\n = 0.01,\n I<\/jats:italic>\n \u00b2 = 59%). Conversely, a fixed-effects model also revealed a significant association in the G vs. A model (OR: 0.84, 95% CI: 0.73\u20130.96,\n P<\/jats:italic>\n = 0.01,\n I<\/jats:italic>\n \u00b2 = 38%). In pneumococcal meningitis, a fixed-effects model analysis demonstrated a significant association in the GG vs. AA model (OR: 0.35, 95% CI: 0.14\u20130.87,\n P<\/jats:italic>\n = 0.02,\n I<\/jats:italic>\n \u00b2 = 48%) respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This meta-analysis showed a strong correlation between\n TLR4<\/jats:italic>\n rs4986790 polymorphism and susceptibility to meningococcal meningitis and pneumococcal meningitis. Further studies with diverse populations are needed to validate and strengthen these findings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aian.aian_443_24","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T09:00:10Z","timestamp":1732266010000},"page":"629-637","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis"],"prefix":"10.4103","volume":"27","author":[{"given":"Praveen Kumar Chandra","family":"Sekar","sequence":"first","affiliation":[{"name":"Human Cytogenetics and Genomics Laboratory, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishnan","family":"Veerabathiran","sequence":"additional","affiliation":[{"name":"Human Cytogenetics and Genomics Laboratory, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"1157023","DOI":"10.1155\/2021\/1157023","article-title":"Toll-Like Receptors (TLRs): Structure, functions, signaling, and role of their polymorphisms in colorectal cancer 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