{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:42:15Z","timestamp":1786650135978,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Although the motor symptoms of Wilson\u2019s disease have received particular attention from researchers and medical professionals, non-motor symptoms might become increasingly prevalent with the advancement of the disease and can even appear before the onset of motor symptoms. However, clinicopathological correlations for most of these non-motor features are still poorly understood. The correlations between non-motor and motor symptoms have been examined in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty patients with Wilson\u2019s disease participated in this study. Each subject was administered the Global Assessment Scale and the Non-Motor Symptom Questionnaire (NMS Quest) for the assessment of motor and non-motor symptoms, respectively. Cognitive functions were evaluated with Addenbrooke\u2019s Cognitive Examination III (Bengali version) and the Digit Span Test. Sleep-related problems were assessed with Pittsburgh Sleep Quality Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the patients who participated in this study, 82%, 56%, 90%, 18%, 82%, 8%, 60%, 56%, and 66% had digestive, urinary, apathy\u2013attention\u2013memory, hallucinations\/delusions, depression\/anxiety, sexual function, cardiovascular, sleep disorder, and miscellaneous (pain, weight, swelling, sweating, and diplopia) symptoms, respectively. NMS-Digestion (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2264 0.001), NMS-Urinary (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), NMS-Miscellany (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), NMS-Memory (0.011), and NMS-Sleep Disorder (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031) significantly predicted parkinsonism. NMS-Digestion was a significant predictor of dystonia (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Awareness regarding non-motor symptoms and their associations with motor symptoms might help physicians develop more efficient treatment regimens that can alleviate non-motor symptoms which can be equally troublesome and disabling for these patients. Management of non-motor symptoms is crucial for the overall well-being of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_503_24","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T01:00:06Z","timestamp":1738890006000},"page":"66-71","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Motor and Non-motor Neurologic Symptoms of Wilson\u2019s Disease: Exploring the Associations"],"prefix":"10.4103","volume":"28","author":[{"given":"Arka Prava","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Postgraduate Medical Education and Research and Bangur Institute of Neurosciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adreesh","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Postgraduate 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasodhara","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Postgraduate Medical Education and Research and Bangur Institute of Neurosciences, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"R1-20250220","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1373\/clinchem.2007.093633","article-title":"Introducing single-nucleotide polymorphism markers in the diagnosis of Wilson disease","volume":"53","author":"Schmidt","year":"2007","journal-title":"Clin 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