{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:13:47Z","timestamp":1786738427802,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Histoplasmosis occurs predominantly in immunocompromised hosts and typically presents with mild constitutional symptoms, weight loss, weakness, fatigability, hepatosplenomegaly, and lymphadenopathy. The diagnosis is generally delayed and is based upon isolating the organism in blood cultures or by identifying intracellular organisms in tissues. Disseminated Histoplasmosis is well described in HIV patients but Histoplasmosis myositis is a rare manifestation and has not been reported in seronegative patients till date. We here address a case of a pharmacologically immunosuppressed patient with extensive Histoplasmosis myositis invading almost all the skeletal muscles of body (including plantar foot muscles) with no evidence of dissemination to other organ-systems. Clinical examination and investigations co-related with infiltrative muscle disease and skeletal muscle biopsy revealed\n                      <jats:italic toggle=\"yes\">Histoplasma capsulatum<\/jats:italic>\n                      . This patient illustrates a distinctive clinical presentation of fungal infection with subtle constitutional symptoms and isolated muscle weakness which added to the diagnostic challenge. Hence, differential diagnosis of fungal infection must always be considered as a cause of myopathy in any pharmacologically immunosuppressed patient.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_511_20","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T04:56:07Z","timestamp":1599022567000},"page":"239-242","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Unabridged Histoplasmosis Myositis"],"prefix":"10.4103","volume":"24","author":[{"given":"Gurparvesh S.","family":"Goraya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guneet","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Updesh","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birinder S.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunchan","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20240828","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/mus.880180509","article-title":"Disseminated histoplasmosis presenting as myositis and fasciitis in a patient with dermatomyositis","volume":"18","author":"Voloshin","year":"1995","journal-title":"Muscle Nerve"},{"key":"R2-22-20240828","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00027-06","article-title":"Histoplasmosis: A clinical and laboratory update","volume":"20","author":"Kauffman","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"R3-22-20240828","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0002-9343(88)80334-6","article-title":"Progressive disseminated histoplasmosis in patients with acquired immunodeficiency syndrome","volume":"85","author":"Johnson","year":"1988","journal-title":"Am J Med"},{"key":"R5-22-20240828","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1148\/rg.2016150051","article-title":"Role of PET\/CT in workup of fever without a source","volume":"36","author":"Dibble","year":"2016","journal-title":"Radiographics"},{"key":"R6-22-20240828","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1128\/AAC.45.8.2354-2357.2001","article-title":"Clearance of fungal burden during treatment of disseminated histoplasmosis with liposomal amphotericin B versus itraconazole","volume":"45","author":"Wheat","year":"2001","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.AIAN_511_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:26:20Z","timestamp":1786735580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.AIAN_511_20"}},"subtitle":["Unsolved Dissemination with Diagnostic Challenge"],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_511_20","relation":{},"ISSN":["0972-2327"],"issn-type":[{"value":"0972-2327","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}