{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:42:29Z","timestamp":1792057349603,"version":"4.4.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    Coenzyme q10 (CoQ10) deficiency is an extremely uncommon disease that has very rarely been reported in adulthood. This case describes an elderly male with ataxia since adolescence, and visual disturbance since 40, presenting with recurrent episodes of seizures. Imaging revealed stroke-like episodes, with other immune and infective evaluations being negative. He was eventually diagnosed to have Primary CoQ10 deficiency secondary to\n                    <jats:italic toggle=\"yes\">CoQ8A<\/jats:italic>\n                    mutation. This account highlights the challenges in diagnosing and managing primary Coenzyme Q10 deficiency, especially when it presents later in life with atypical features such as stroke-like episodes.\n                  <\/jats:p>","DOI":"10.4103\/aian.aian_511_23","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:39:21Z","timestamp":1697038761000},"page":"980-982","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Stroke-Like Episodes and Epilepsy in a Patient with COQ8A-Related Coenzyme Q10 Deficiency"],"prefix":"10.4103","volume":"26","author":[{"given":"Rithvik","family":"Ramesh","sequence":"first","affiliation":[{"name":"Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India"},{"name":"Consultant Neurologist, Hariharan Diabetes and Heart Care Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundar","family":"Hariharan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hariharan Diabetes and Heart Care Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Anasthesiology, Hariharan Diabetes and Heart Care Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"R1-20260511","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archneurol.2012.206","article-title":"Heterogeneity of coenzyme Q10 deficiency: Patient study and literature review","volume":"69","author":"Emmanuele","year":"2012","journal-title":"Arch Neurol"},{"key":"R2-20260511","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/ene.13003","article-title":"ADCK3 mutations with epilepsy, stroke-like episodes and ataxia: A POLG mimic?","volume":"23","author":"Hikmat","year":"2016","journal-title":"Eur J Neurol"},{"key":"R3-20260511","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/jnnp-2011-301258","article-title":"Adult-onset cerebellar ataxia due to mutations in CABC1\/ADCK3","volume":"83","author":"Horvath","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R4-20260511","doi-asserted-by":"crossref","first-page":"e1420","DOI":"10.1002\/mgg3.1420","article-title":"Primary coenzyme Q10 deficiency due to COQ8A gene mutations","volume":"8","author":"Zhang","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"R5-20260511","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ajhg.2007.12.024","article-title":"ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency","volume":"82","author":"Lagier-Tourenne","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"Suppl","key":"R6-20260511","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1016\/j.mito.2007.03.002","article-title":"Coenzyme Q10 and statins: Biochemical and clinical implications","volume":"7","author":"Littarru","year":"2007","journal-title":"Mitochondrion"},{"key":"R7-20260511","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s11357-020-00208-x","article-title":"Poor mitochondrial health and systemic inflammation? 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