{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:51Z","timestamp":1792696251804,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Although widely described in Parkinson\u2019s disease (PD), peripheral neuropathy (PNP) is scarcely reported in progressive supranuclear palsy (PSP). We aimed to compare the frequency, clinical and electrophysiologic characteristics of PNP in PSP and PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study included 23 PSP and 93 PD patients. Demographic data, Movement Disorders Society-Unified Parkinson\u2019s Disease Rating Scale-III (MDS-UPDRS-III), Hoehn\u2013Yahr staging, Toronto Clinical Neuropathy Score, nerve conduction study (NCS), and sympathetic skin response (SSR) were recorded. Diagnosing isolated large fiber neuropathy required abnormal NCS. Isolated small fiber neuropathy required clinical findings of pinprick and thermal sensory loss and\/or allodynia and\/or hyperalgesia with\/without impaired SSR, along with normal NCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PNP was commoner in PSP than PD (65.2% vs. 50.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.21). While a comparable proportion in both groups had clinical neuropathy, NCS abnormalities predominated in PSP (65.2% vs. 39.8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). All patients had distal symmetrical axonal polyneuropathy. A significantly higher proportion of PSP patients had large fiber involvement (65.21% vs. 39.78%, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 4.82;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) and mixed fiber PNP (60.9% vs. 33.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). PSP patients with neuropathy had a significantly shorter disease duration [median (interquartile range {IQR} = 2 (2-3) years vs. 6 (3-9) years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001], higher MDS-UPDRS-III score [median (IQR) = 47 (36\u201354) vs. 34 (28\u201349),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049], higher Hoehn\u2013Yahr stage [median (IQR) = 4 (2\u20135) vs. 3 (1\u20135),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001], and shorter duration of levodopa use [median (IQR) = 2 (1-2) years vs. 3.5 (2-5) years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006]. NCS parameters were comparable between PSP and PD patients with neuropathy. While PNP in PSP was not associated with any of the clinical variables, a longer disease duration was independently associated with PNP in PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PNP affected two-thirds of PSP patients and was more prevalent than PD. Both groups had distal symmetrical axonal polyneuropathy, with mixed fiber PNP predominating in PSP. A longer disease duration in PD was associated with PNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_512_24","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T02:00:10Z","timestamp":1733450410000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Clinical and Electrophysiologic Characteristics of Peripheral Neuropathy in Progressive Supranuclear Palsy and Parkinson\u2019s Disease: An Observational Study"],"prefix":"10.4103","volume":"28","author":[{"given":"Yumkham M","family":"Devi","sequence":"first","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mritunjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minakshi","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"},{"name":"Department of Geriatric Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweety","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"},{"name":"Department of Neurology, All India Institute of Medical Sciences, Bibinagar, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"R1-20250220","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11910-018-0819-5","article-title":"Progressive supranuclear palsy: An Update","volume":"18","author":"Armstrong","year":"2018","journal-title":"Curr Neurol Neurosci Rep"},{"key":"R2-20250220","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1212\/WNL.0b013e31823a0ee4","article-title":"Neuropathy in Parkinson disease: Prevalence and 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