{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:14:51Z","timestamp":1791616491076,"version":"4.3.4"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>COVID-19 infection is associated with neurological manifestations, including various types of movement disorders (MD). A thorough review of individual patients with COVID-19-induced MD would help in better understanding the clinical profile and outcome of these patients and in prognostication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We conducted an individual patient-systematic review to study the clinical and imaging profile and outcomes of patients with COVID-19-associated MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic literature search of PubMed, EMBASE, and Cochrane databases was conducted by two independent reviewers. Individual patient data COVID from case reports and case series on COVID-19-associated MD, published between December 2019 and December 2022, were extracted and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data of 133 patients with COVID-19-associated MD from 82 studies were analyzed. Mean age was 55 \u00b1 18 years and 77% were males. A mixed movement disorder was most commonly seen (41%); myoclonus-ataxia was the most frequent (44.4%). Myoclonus significantly correlated with age (odds ratio (OR) 1.02\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03, CI 1-1.04). Tremor had the longest latency to develop after SARS-CoV-2 infection [median (IQR) 21 (10-40) days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009, CI 1.01-1.05]. At short-term follow-up, myoclonus improved (OR 14.35,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value = 0.01, CI 1.71-120.65), whereas parkinsonism (OR 0.09,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value = 0.002, CI 0.19-0.41) and tremor (OR 0.16,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value = 0.016, CI 0.04-0.71) persisted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Myoclonus-ataxia was the most common movement disorder after COVID-19 infection. Myoclonus was seen in older individuals and usually improved. Tremor and parkinsonism developed after a long latency and did not improve in the short-term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_572_23","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:00:08Z","timestamp":1698116408000},"page":"702-707","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["De Novo Movement Disorders Associated with COVID-19- A Systematic Review of Individual Patients"],"prefix":"10.4103","volume":"26","author":[{"given":"Kanchana S.","family":"Pillai","sequence":"first","affiliation":[{"name":"Department of Neurology, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale University School of Medicine, New Haven, CT, 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