{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:29:31Z","timestamp":1786728571600,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>One or more inexcitable motor (IM) nerves are common during electrodiagnostic (EDx) study in Guillain\u2013Barr\u00e9 syndrome (GBS). This study assessed the dose\u2013effect relationship of IM nerves on outcome in patients with acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor and\/or sensory axonal neuropathy (AMAN and AMSAN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Eighty-eight GBS patients admitted during May 2018\u2013June 2023 underwent detailed clinical evaluation and EDx study. Admission and follow-up disability were assessed on a 0\u201310 Clinical Grading Scale (CGS). Outcome was recovery at 6 months, defined as good (CGS &lt;3) and poor (CGS \u22653). Binary multivariate logistic regression with backward elimination was used to calculate independent predictors of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Proportion of patients with complete recovery decreased significantly with increasing numbers of IM nerves (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Seventy-six patients were followed for 6 months. Among patients with IM nerves (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 28), complete recovery was similar between AIDP and axonal GBS (70% vs. 50%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.40). However, in patients with recordable compound muscle action potentials (CMAPs) in all the motor nerves (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 26), axonal GBS had significantly poor recovery compared to AIDP (75% vs. 9.1%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). Among patients receiving intravenous immunoglobulin (IVIg;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 42), poor recovery was seen in 53.6% with IM nerves compared to 35.7% without (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.28), while it was 37.5% versus 5.6% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04), respectively, in those who did not receive IVIg (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 34). However, only admission disability (odds ratio [OR] 0.88, 95% confidence interval [CI] 0.81\u20130.97;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007) was found to be an independent predictor of outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although increasing numbers of IM nerves were associated with poor outcome on univariate analysis, they did not predict 6 months\u2019 outcome independently. Outcome did not differ between axonal GBS and AIDP among those with IM nerves. IVIg improved outcome in patients with IM nerves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aian.aian_641_23","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:01:48Z","timestamp":1703631708000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Dose\u2013Effect Relationship of Motor Nerve Inexcitability on Outcome in Guillain\u2013Barr\u00e9 Syndrome: A Prospective Cohort Study"],"prefix":"10.4103","volume":"26","author":[{"given":"Mritunjai","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,26]]},"reference":[{"key":"R2-20260511","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ana.410440512","article-title":"Electrophysiological classification of Guillain-Barr\u00e9 syndrome: Clinical associations and outcome. 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