{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:28Z","timestamp":1787071348567,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sickle cell disease (SCD), a hereditary blood disorder in India, disproportionately affects Adivasi communities burdened by socio-economic and systemic inequities. Stroke, a severe complication of SCD, is underexplored in Indian populations, especially among Adivasi groups. This pilot study evaluated the feasibility of transcranial Doppler (TCD) screening in a peripheral healthcare setting in Karnataka, focusing on Adivasi SCD patients. Among 39 participants (27 HbSS, three HbS\u03b20, nine HbAS) from a hemoglobinopathy registry, none exhibited elevated time-averaged maximum mean (TAMM) velocities, but 73.3% of SCD patients showed unusually low middle cerebral artery (MCA) velocities (&lt;70 cm\/s). Significant differences in basilar artery (BA) flow velocities were noted between SCD and sickle cell trait (SCT) patients (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.05), while MCA parameters were comparable. The findings establish baseline TCD velocities and highlight the need for region-specific stroke prevention guidelines tailored to underserved Adivasi populations.\n                  <\/jats:p>","DOI":"10.4103\/aian.aian_65_25","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:00:10Z","timestamp":1749016810000},"page":"585-589","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Transcranial Doppler Screening in Sickle Cell Disease: Insights from a Regional Study in Karnataka, India"],"prefix":"10.4103","volume":"28","author":[{"given":"Suryanarayana","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Neurology, Apollo Hospitals, Bannerghatta Road, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagadguru Sri Shivarathreeshwara Medical College, Mysuru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Gowrishankar","sequence":"additional","affiliation":[{"name":"Senthil Multi-Specialty Hospital, Erode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Centre of Adivasis Health, Institute of Public Health, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Neurology, National University Hospital and Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Ramachandraiah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Apollo Hospitals, Bannerghatta Road, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Jagadguru Sri Shivarathreeshwara Medical College, Mysuru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"R1-20250821","doi-asserted-by":"crossref","first-page":"101678","DOI":"10.1016\/j.cegh.2024.101678","article-title":"Prevalence of Sickle cell disease, Sickle cell trait and HBS-beta-thalassemia in India: A systematic review and Meta-analysis","volume":"28","author":"Rao","year":"2024","journal-title":"Clin Epidemiol Glob Health"},{"key":"R2-20250821","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM199807023390102","article-title":"Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography","volume":"339","author":"Adams","year":"1998","journal-title":"N Engl J Med"},{"key":"R3-20250821","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1182\/bloodadvances.2019001142","article-title":"American Society of Hematology 2020 guidelines for sickle cell disease: Prevention, diagnosis, and treatment of cerebrovascular disease in children and adults","volume":"4","author":"DeBaun","year":"2020","journal-title":"Blood Adv"},{"key":"R4-20250821","first-page":"249","article-title":"Study of-maximum systolic velocities and mean maximum velocities of skull base arteries recorded with transcranial Doppler in adult sickle cell patients without neurovascular complication","volume":"44","author":"Desnos","year":"2019","journal-title":"J Med Vasc"},{"key":"R5-20250821","doi-asserted-by":"crossref","first-page":"117510","DOI":"10.1016\/j.jns.2021.117510","article-title":"Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries","volume":"427","author":"Bhattacharya","year":"2021","journal-title":"J Neurol Sci"},{"key":"R6-20250821","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/bjh.17698","article-title":"Hydroxycarbamide treatment reduces transcranial Doppler velocity in the absence of transfusion support in children with sickle cell anaemia, elevated transcranial Doppler velocity, and cerebral vasculopathy: The EXTEND trial","volume":"195","author":"Rankine-Mullings","year":"2021","journal-title":"Br J Haematol"},{"issue":"(Suppl 1)","key":"R7-20250821","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1182\/blood-2019-131416","article-title":"Transcranial Doppler screening in children with sickle cell anemia is feasible in central India and reveals high risk of stroke","volume":"134","author":"Jain","year":"2019","journal-title":"Blood"},{"key":"R8-20250821","first-page":"E29882","article-title":"Cerebral hemodynamics in children with sickle cell disease in India: An observational cohort study","volume":"101","author":"Gajjar","year":"2022","journal-title":"Medicine (United States)"},{"key":"R9-20250821","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5455\/njcm.20211202113451","article-title":"Transcranial doppler screening in children with sickle cell disease of south gujarat population","volume":"12","author":"Desai","year":"2021","journal-title":"Natl J Community Med"},{"key":"R10-20250821","doi-asserted-by":"crossref","first-page":"856","DOI":"10.16965\/ijar.2014.547","article-title":"Sickle children vs normal children: A transcranial and extracranial doppler stud","volume":"3","author":"Singhal","year":"2015","journal-title":"Int J Anat Res"},{"key":"R11-20250821","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/pbc.26085","article-title":"Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: Evidence against a milder clinical phenotype in India","volume":"63","author":"Jain","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"R12-20250821","doi-asserted-by":"crossref","first-page":"1384767","DOI":"10.3389\/fstro.2024.1384767","article-title":"Transcranial Doppler in 150 Congolese children with sickle cell disease","volume":"3","author":"Kazadi","year":"2024","journal-title":"Front Stroke"},{"key":"R13-20250821","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jha2.818","article-title":"Transcranial Doppler ultrasound velocities in a population of unstudied African children with sickle cell anemia","volume":"5","author":"O'Brien","year":"2024","journal-title":"eJHaem"},{"key":"R14-20250821","first-page":"543","article-title":"Neurocognitive Improvement with Hydroxyurea Therapy in Children with Sickle Cell Anemia in Uganda: Analysis from the Completed 30-Month BRAIN Safe II Trial","volume":"144","author":"Naggayi","journal-title":"Blood 2024 Nov 5"},{"key":"R15-20250821","first-page":"229","article-title":"Transcranial Doppler in screening of sickle cell disease in Basrah: A cross- sectional descriptive study","volume":"12","author":"Basim Alhijaj","year":"2025","journal-title":"Front Biomed Technol"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_65_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:45Z","timestamp":1787067885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_65_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_65_25","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"2025-01-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}